EGFR1 Signaling Pathway (Pan troglodytes)

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1NucleusNUUbiquitinationPMCYPMMACYCYPMPMCYSumoylationNUProteolytic cleavageCYCYCYMAMitochondrionMAMADesumoylationCYMolecule in the pathwayAutophosphorylationNUCYCYDemethylationEndoplasmic reticulumECCYCYCYPMEndosomePMMAENERCYPMCYMAPMAcetylationCYMethylationPMDCYCYCYPMGlycosylationPMMAPMCYCYNUMADephosphorylationNUPMReaction through unknown mechanisms/moleculesGOPlasma membraneNUMANUExtracellularCYNUNUGene SymbolCYNU(Protein-protein interaction)MAPMAccession Number : NetPath 4; cellmap:4AutodephosphorylationMACYENDMAENCYCYNUPMDMAProteins in a complex interactionMANUNUMACYDeubiquitinationPMNUCYPMCYMACYNUPhosphorylationPMLigandActivationPMCYRecruitmentCytoplasmInhibitionMANUCYPMCYPMGolgi apparatusNUMADeacetylationTranslocationNUCYPalmitoylationMAControlPMMANUEnzyme complexCYNUMolecular associationMAMTReceptorSTAT5AGRB7MAPK8CTNND1ERRFI1STXBP1PRKCGSP1ARF4RIPK1ELK4PTPRREGFPIK3R1PRKCIASAP1STXBP1PTPN12ARAFSOCS3REPS2KRT18MYCSRCPEBP1APPL1TGIF1CSKITCHSPRY2PTPN5PLSCR1SIN3AELF3SH3GL2RALBRPS6KA5ARF4STAT1MAP2K2LOC464259HIP1STAT3HTTSH3GL2NDUFA13PRKAR1ASTAT1YWHABAPPL2MAP2K3PLD2PLCG1JUNMAPK1SHOC2CBLBSTAT5ACRKLTNK2SHC1VAV1STAT1SH3KBP1STAT2USP6NLSTAT5BPRKCASH2D3CCREB1PIK3R2PLD1PIK3C2BZNF259ELF3RAB5AEGFRMAPK7AP2A1PIK3CDSH2D3CMAPK14EGFRFOSKRT7ARF4CAV1EGFRRPS6KA2CEBPBMAP2K7STAT2KLF11APPL2SH3GL3GRB14PTPN6PIK3CBGJA1MCF2BCAR1PKN2MAPK1GAB2PRKCALOC459737PIK3R3TNIP1JUNDAPPL1CRKRALBP1PRKD1SOS1PLCG1CDC42NCK2CAV2KRT17PTPN6SHC1RPS6KA3GIT1EEF1A1EPS8NRASPLCG2EPS15L1PTPN11SNRPD2EPS15PAK1EPS15GRB10EPN1CEBPASH3BGRLSTAT3MAP3K1RFXANKREPS1EEF1A1SMAD2MAP2K5CEACAM1WNK1SOS2FOXO1CASP9RASA1PRKCB1PLEC1PXNSMAD3RPS6KA3CAMK2AVAV3MAP3K2PIK3CAMAP2K1MTA2MAPK3EGFJAK2RPS6KA1PLD1GRB2SPRY2MAP3K14CBLCDOK2SNCAMAP3K4EPPK1PTK2BEGFRINPPL1HIST3H3BCAR1HRASGAB1VAV2PITPNARALGDSRBBP7PLCG2MAP2K1RAF1NCK1DUSP1MAP3K2MAP3K3KRASSTAT3FOXO1KRT8PIK3CGABI1APPL1RGS16EGFPRKCZWASLSMAD2ELK1AKT1SMAD3GAB1JAK1RAF1RAC1PTK6DUSP1ZNF259ATF1DNM1CBLSOCS1


Description

No description

Comments

GenMAPP notes 
NetPath 4; cellmap:4 - EGFR1 Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP437(r21600) with a 78% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV; ''Control of MAPK signalling: from complexity to what really matters.''; Oncogene, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
69215view18:32, 8 July 2013MaintBotUpdated to 2013 gpml schema
67180view10:17, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
41517view01:56, 2 March 2011MaintBotRemoved redundant pathway information and comments
35720view23:29, 12 February 2010AlexanderPico
35436view11:33, 12 February 2010MichielAdded ref
34257view21:49, 9 December 2009MaintBotAutomatic update of empty xrefs
30429view21:18, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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ARAFGeneProduct
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YWHABGeneProduct
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Annotated Interactions

No annotated interactions
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