Cholesterol Biosynthesis (Gallus gallus)

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1-7Fatty Acid Degradation(S)-2,3-Epoxysqualene7-DehydrocholesterolMVKFDPSLanosterinFDPSCholesterolDimethylallylpyrophosphateMevalonic acid-5PSQLEisopentenyl pyrophosphateCYP51A1HMGCRMVDHMGCS1LathosterolMevalonic acid 5-pyrophosphatePMVKNSDHLfarnesyl pyrophosphateSC5DLSC4MOLHMG-CoAFDFT1IDI1DHCR7Acetyl-CoAGeranyl-PPMevalonic acidLSSSqualene


No description


This pathway was inferred from Homo sapiens pathway WP197(r21093) with a 82% conversion rate.

Quality Tags

Ontology Terms



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  1. Li L, Kaplan J; ''Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue.''; J Biol Chem, 1996 PubMed Europe PMC
  2. Noshiro M, Aoyama Y, Kawamoto T, Gotoh O, Horiuchi T, Yoshida Y; ''Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: I. Structural analyses of the gene and multiple sizes of mRNA.''; J Biochem, 1997 PubMed Europe PMC
  3. Ohashi M, Mizushima N, Kabeya Y, Yoshimori T; ''Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets.''; J Biol Chem, 2003 PubMed Europe PMC
  4. Sagami H, Korenaga T, Ogura K; ''Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate.''; J Biochem, 1993 PubMed Europe PMC
  5. Liu XY, Dangel AW, Kelley RI, Zhao W, Denny P, Botcherby M, Cattanach B, Peters J, Hunsicker PR, Mallon AM, Strivens MA, Bate R, Miller W, Rhodes M, Brown SD, Herman GE; ''The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase.''; Nat Genet, 1999 PubMed Europe PMC
  6. Bard M, Bruner DA, Pierson CA, Lees ND, Biermann B, Frye L, Koegel C, Barbuch R; ''Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase.''; Proc Natl Acad Sci U S A, 1996 PubMed Europe PMC
  7. Gaylor JL; ''Membrane-bound enzymes of cholesterol synthesis from lanosterol.''; Biochem Biophys Res Commun, 2002 PubMed Europe PMC


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101764view13:46, 7 November 2018EgonwReplaced a wrong CAS number of with right ChEBI identifier.
72378view13:17, 13 November 2013EgonwRemoved a few data sources where no identifier was given.
68863view17:21, 8 July 2013MaintBotUpdated to 2013 gpml schema
67115view10:08, 26 June 2013Christine ChichesterOntology Term : 'cholesterol biosynthetic pathway' added !
41001view22:56, 1 March 2011MaintBotRemoved redundant pathway information and comments
35154view14:24, 11 February 2010ThomasModified description
35153view14:23, 11 February 2010Thomasmoved literature from genmapp comments to bibliography
33922view18:07, 9 December 2009MaintBotAutomatic update of empty xrefs
33503view15:14, 30 November 2009MaintBotRemoved group label
30402view21:10, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
(S)-2,3-EpoxysqualeneMetabolite9029-62-3 (CAS)
7-DehydrocholesterolMetabolite434-16-2 (CAS)
CYP51A1GeneProduct420548 (Entrez Gene)
CholesterolMetabolite57-88-5 (CAS)
DHCR7GeneProduct422982 (Entrez Gene)
DimethylallylpyrophosphateMetabolite358-72-5 (CAS)
FDFT1GeneProduct422038 (Entrez Gene)
FDPSGeneProduct425061 (Entrez Gene)
Geranyl-PPMetabolite6699-20-3 (CAS)
HMGCRGeneProduct395145 (Entrez Gene)
HMGCS1GeneProduct396379 (Entrez Gene)
IDI1GeneProduct420459 (Entrez Gene)
LSSGeneProduct424037 (Entrez Gene)
LanosterinMetabolite79-63-0 (CAS)
LathosterolMetabolite80-99-9 (CAS)
MVDGeneProduct425359 (Entrez Gene)
MVKGeneProduct768555 (Entrez Gene)
Mevalonic acid 5-pyrophosphateMetabolite1492-08-6 (CAS)
Mevalonic acid-5PMetabolite73566-35-5 (CAS)
Mevalonic acidMetabolite150-97-0 (CAS)
NSDHLGeneProduct422302 (Entrez Gene) NAD(P) dependent steroid dehydrogenase-like
SC4MOLGeneProduct422423 (Entrez Gene)
SQLEGeneProduct420335 (Entrez Gene)
SqualeneMetabolite111-02-4 (CAS)
farnesyl pyrophosphateMetabolite13058-04-3 (CAS)
isopentenyl pyrophosphateMetabolite358-71-4 (CAS)

Annotated Interactions

No annotated interactions
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