Integrin-mediated cell adhesion (Gallus gallus)

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Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: Wikipedia


This pathway was inferred from Homo sapiens pathway WP185(r21067) with a 73% conversion rate.

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Ontology Terms



  1. Sepulveda JL, Gkretsi V, Wu C; ''Assembly and signaling of adhesion complexes.''; Curr Top Dev Biol, 2005 PubMed Europe PMC Scholia


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109471view11:03, 18 March 2020L DupuisFixed interactions
72066view17:32, 24 October 2013MaintBotremoved data source from nodes without identifier
68880view17:22, 8 July 2013MaintBotUpdated to 2013 gpml schema
67404view10:57, 26 June 2013DdiglesOntology Term : 'integrin mediated signaling pathway' added !
62680view18:32, 1 May 2013MaintBotUpdated Ensembl and UniProt data source
41022view22:57, 1 March 2011MaintBotRemoved redundant pathway information and comments
35603view15:47, 12 February 2010ThomasModified description
35596view15:43, 12 February 2010Thomasadded literature
33943view18:14, 9 December 2009MaintBotAutomatic update of empty xrefs
33502view15:13, 30 November 2009MaintBotRemoved group label
30401view21:10, 29 July 2009MaintBotNew pathway

External references


View all...
NameTypeDatabase referenceComment
AKT1GeneProduct395928 (Entrez Gene) AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
AKT2GeneProduct373973 (Entrez Gene) AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
AKT3GeneProduct421497 (Entrez Gene) AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
ARAFGeneProductARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
ARHGEF7GeneProduct418761 (Entrez Gene) ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
BCAR1GeneProduct415691 (Entrez Gene) BCAR1; breast cancer anti-estrogen resistance 1
BRAFGeneProduct396239 (Entrez Gene) BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
CAPN10GeneProduct424945 (Entrez Gene) CAPN10; calpain 10 [EC:
CAPN11GeneProductCAPN11; calpain 11 [EC:]
CAPN1GeneProduct396240 (Entrez Gene) CAPN1; calpain 1 (mu/I) large subunit [EC:]
CAPN2GeneProduct395963 (Entrez Gene) CAPN2; calpain 2 (m/II) large subunit [EC:]
CAPN3GeneProduct423233 (Entrez Gene) CAPN3; calpain 3 (p94) [EC:]
CAPN5GeneProduct419086 (Entrez Gene) CAPN5; calpain
CAPN6GeneProduct422341 (Entrez Gene) CAPN6; calpain 6 [EC:]
CAPN7GeneProduct420683 (Entrez Gene) CAPN7; calpain 7 [EC:
CAPN9GeneProduct421544 (Entrez Gene) CAPN9; calpain 9 (nCL-4) [EC:
CAPNS1GeneProduct770982 (Entrez Gene) CAPNS1; calpain small subunit 1 [EC:]
CAV1GeneProduct373996 (Entrez Gene) CAV1; caveolin 1 caveolae protein 22kD
CAV2GeneProduct417772 (Entrez Gene) CAV2; caveolin 2
CAV3GeneProduct378796 (Entrez Gene) CAV3; caveolin 3
CDC42GeneProduct395917 (Entrez Gene) CDC42; cell division cycle 42 (GTP binding protein 25kD)
CRKGeneProduct417553 (Entrez Gene) CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
CSKGeneProduct396396 (Entrez Gene) CSK; c-src tyrosine kinase [EC:]
DOCK1GeneProduct423960 (Entrez Gene) DOCK1; dedicator of cyto-kinesis
FYNGeneProduct396294 (Entrez Gene) FYN; FYN oncogene related to SRC FGR YES [EC:]
GIT2GeneProduct374035 (Entrez Gene) GIT2; G protein-coupled receptor kinase-interactor 2
GRB2GeneProduct386572 (Entrez Gene) GRB2; growth factor receptor-bound protein 2
HRASGeneProduct396229 (Entrez Gene)
ILKGeneProduct374018 (Entrez Gene) ILK; integrin-linked kinase [EC:2.7.1.-]
ITGA11GeneProduct415560 (Entrez Gene)
ITGA1GeneProduct395951 (Entrez Gene)
ITGA3GeneProduct373946 (Entrez Gene)
ITGA4GeneProduct424121 (Entrez Gene)
ITGA5GeneProduct378932 (Entrez Gene)
ITGA6GeneProduct396226 (Entrez Gene)
ITGA8GeneProduct396225 (Entrez Gene)
ITGA9GeneProduct420757 (Entrez Gene)
ITGAVGeneProduct396420 (Entrez Gene)
ITGB1GeneProduct374058 (Entrez Gene)
ITGB2GeneProduct396181 (Entrez Gene)
ITGB3GeneProduct374209 (Entrez Gene)
ITGB4GeneProduct417374 (Entrez Gene)
ITGB5GeneProduct395142 (Entrez Gene)
ITGB6GeneProduct424191 (Entrez Gene)
ITGB8GeneProduct420605 (Entrez Gene)
MAP2K1GeneProduct415549 (Entrez Gene) MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
MAP2K2GeneProduct396349 (Entrez Gene) MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
MAP2K6GeneProductMAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
MAPK10GeneProduct422592 (Entrez Gene)
MAPK12GeneProduct769763 (Entrez Gene) MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
MAPK1GeneProduct373953 (Entrez Gene) MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
MAPK4GeneProductMAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
MAPK7GeneProductMAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
MYLK2GeneProduct396356 (Entrez Gene) MYLK2; myosin light chain kinase 2 skeletal muscle [EC:
PAK1GeneProduct419083 (Entrez Gene) PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
PAK2GeneProduct424860 (Entrez Gene) PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
PAK3GeneProduct422342 (Entrez Gene) PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
PAK4GeneProduct770462 (Entrez Gene) PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
PAK6GeneProduct428837 (Entrez Gene) PAK6; p21(CDKN1A)-activated kinase
PDPK1GeneProduct416588 (Entrez Gene) PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:]
PIK3R2GeneProduct771142 (Entrez Gene) PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
PTK2GeneProduct396416 (Entrez Gene) PTK2; PTK2 protein tyrosine kinase 2 [EC:
PXNGeneProduct395832 (Entrez Gene) PXN; paxillin
RAC1GeneProduct395871 (Entrez Gene) RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
RAC2GeneProduct418044 (Entrez Gene) RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
RAC3GeneProduct395870 (Entrez Gene) RAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
RAF1GeneProduct396245 (Entrez Gene) RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
RAP1AGeneProduct419867 (Entrez Gene) RAP1A; RAP1A member of RAS oncogene family
RAP1BGeneProduct417840 (Entrez Gene) RAP1B; RAP1B member of RAS oncogene family
RAPGEF1GeneProduct417173 (Entrez Gene) GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
RCJMB04_36h7GeneProduct415557 (Entrez Gene) MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
RCJMB04_5i17GeneProduct415419 (Entrez Gene) MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
RCJMB04_8f10GeneProduct416496 (Entrez Gene) MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
RHOGeneProduct396486 (Entrez Gene) RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
ROCK1GeneProduct373970 (Entrez Gene) ROCK1; Rho-associated coiled-coil containing protein kinase
ROCK2GeneProduct374182 (Entrez Gene) ROCK2; Rho-associated coiled-coil containing protein kinase
SEPP1GeneProduct431587 (Entrez Gene) SEPP1; selenoprotein P plasma
SHC1GeneProduct395934 (Entrez Gene) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
SHC3GeneProduct431265 (Entrez Gene) SHC3; neuronal Sh
SORBS1GeneProduct423749 (Entrez Gene) SH3D5; SH3-domain protein 5 (ponsin
SOS1GeneProduct425964 (Entrez Gene) SOS1; son of sevenless homolog 1 (Drosophila)
SRCGeneProduct396442 (Entrez Gene) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:]
TLN1GeneProduct395194 (Entrez Gene) TLN1; talin 1
TNS1GeneProduct396439 (Entrez Gene) TNS; tensi
VASPGeneProductVASP; vasodilator-stimulated phosphoprotein
VAV2GeneProduct373938 (Entrez Gene) VAV2; vav 2 oncogene
VAV3GeneProduct373939 (Entrez Gene) VAV3; vav 3 oncogene
VCLGeneProduct396422 (Entrez Gene) VCL; vinculin
ZYXGeneProduct418300 (Entrez Gene) ZYX; zyxin

Annotated Interactions

No annotated interactions
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