Toll-like receptor signaling pathway (Gallus gallus)

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Costimulatory molecules(anti-viral compounds)Specific pathwayin pDCsFlagellar assemblyPeptidoglycan(G+)CpG DNAImidazoquinolin+(Neutrophil, immature DC,+MyD88-independent pathwayAutocrine / Paracrineinteraction+p+p+pAntiviral effectsInflammatory cytokinescoagulation cascadesChemotacticMAPK signaling pathwayEndosome+pFlagellinLipoarabinomannanNK cell)(T cell)LPS(G-)Ubiquitin mediated proteolysisssRNA+pProinflammatoryT cell stimulationJak-STAT signaling pathway+p+p+pMyD88-dependent pathway+pZymosan (Yeast)effects+peffects+pChemotacticDegradationIKK+pCytokine-cytokine receptorLipopolysaccharide+p+p+pdsRNALipoproteinUnmethylatedbiosynthesisInflammatory cytokinesDNAeffectsComplement andApoptosis(Mycobacteria)IRF7TICAM2NFKBIAIRF3LY96AKT3CCL5IL12BMYD88MAP3K7IP1TLR6IFNA10NFKB2RCJMB04_19h23TOLLIPIFNA21IFNA14NFKB1MAP3K7IP2TLR2MYD88PIK3CBIFNA17TLR3IL6TRAF3PIK3R1JUNMAPK9AKT1MAPK11TBK1TICAM1FOSMAP2K6SPP1RIPK1MAP2K7IL12AIRAK1TNFIFNA6TIRAPMAPK1CCL3AKT2IFNA8PIK3CACCL4PIK3R2IFNB1TLR5IFNA16IRAK4IFNA1RELACD14LBPRCJMB04_8f10MYD88IFNB1CD40MAP2K4CXCL11RCJMB04_17i9MAPK14TLR7TLR1MAPK10IFNA5MAPK13CXCL10IL1BMAP3K8PIK3R3NFKB1CASP8MAP2K2IFNAR2CD80MYD88MAPK3TRAF6TRAF6PIK3CDIKBKGCXCL9RAC1MAP3K7TLR2IL8IFNA7IFNAR1TLR9IFNB1TLR8IKBKETLR4MAP2K1IRAK4FADDIFNA13MAPK12PIK3CGRCJMB04_19h23TIRAPIFNA4IFNA2IKBKBMAPK8PIK3R5RCJMB04_17b14TRAF6CD86IRAK1


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP75(r30264) with a 56% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography


History

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CompareRevisionActionTimeUserComment
61667view18:54, 16 April 2013MaintBotDeleted pathway:
40943view22:52, 1 March 2011MaintBotRemoved redundant pathway information and comments
33872view17:50, 9 December 2009MaintBotAutomatic update of empty xrefs
33499view15:13, 30 November 2009MaintBotRemoved group label
31546view21:50, 13 August 2009MaintBotFixed text labels
30398view21:09, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct395928 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
AKT2GeneProduct373973 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
AKT3GeneProduct421497 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
CASP8GeneProduct395284 (Entrez Gene) Original kegg element: gene;87;hsa:841
CCL3GeneProductOriginal kegg element: gene;44;hsa:6348
CCL4GeneProduct395551 (Entrez Gene) Original kegg element: gene;38;hsa:6351
CCL5GeneProduct417465 (Entrez Gene) Original kegg element: gene;58;hsa:6352
CD14GeneProduct100194427 (Entrez Gene) Original kegg element: gene;84;hsa:929
CD40GeneProduct395385 (Entrez Gene) Original kegg element: gene;29;hsa:958
CD80GeneProduct768950 (Entrez Gene) Original kegg element: gene;69;hsa:941
CD86GeneProduct427944 (Entrez Gene) Original kegg element: gene;28;hsa:942
CXCL10GeneProductOriginal kegg element: gene;25;hsa:3627
CXCL11GeneProductOriginal kegg element: gene;23;hsa:6373
CXCL9GeneProductOriginal kegg element: gene;24;hsa:4283
FADDGeneProduct776859 (Entrez Gene) Original kegg element: gene;56;hsa:8772
FOSGeneProduct396512 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
IFNA1GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA10GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA13GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA14GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA16GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA17GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA2GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA21GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA4GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA5GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA6GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA7GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA8GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNAR1GeneProduct395665 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
IFNAR2GeneProduct395664 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
IFNB1GeneProductOriginal kegg element: gene;1;hsa:3456
IKBKBGeneProduct426792 (Entrez Gene) Original kegg element: gene;36;hsa:3551
IKBKEGeneProduct430480 (Entrez Gene) Original kegg element: gene;54;hsa:9641
IKBKGGeneProductOriginal kegg element: gene;85;hsa:8517
IL12AGeneProduct407090 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
IL12BGeneProduct404671 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
IL1BGeneProduct395196 (Entrez Gene) Original kegg element: gene;51;hsa:3553
IL6GeneProduct395337 (Entrez Gene) Original kegg element: gene;57;hsa:3569
IL8GeneProduct396495 (Entrez Gene) Original kegg element: gene;43;hsa:3576
IRAK1GeneProductOriginal kegg element: gene;41;hsa:3654
IRAK4GeneProduct417796 (Entrez Gene) Original kegg element: gene;86;hsa:51135
IRF3GeneProductOriginal kegg element: gene;67;hsa:3661
IRF7GeneProduct396330 (Entrez Gene) Original kegg element: gene;20;hsa:3665
JUNGeneProduct424673 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
LBPGeneProductOriginal kegg element: gene;77;hsa:3929
LY96GeneProduct420189 (Entrez Gene) Original kegg element: gene;71;hsa:23643
MAP2K1GeneProduct415549 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
MAP2K2GeneProduct396349 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
MAP2K4GeneProduct417312 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
MAP2K6GeneProductOriginal kegg element: gene;65;hsa:5606 hsa:5608
MAP2K7GeneProductOriginal kegg element: gene;63;hsa:5609 hsa:6416
MAP3K7GeneProduct421808 (Entrez Gene) Original kegg element: gene;37;hsa:6885
MAP3K7IP1GeneProduct418014 (Entrez Gene) Original kegg element: gene;59;hsa:10454
MAP3K7IP2GeneProduct421622 (Entrez Gene) Original kegg element: gene;61;hsa:23118
MAP3K8GeneProduct420479 (Entrez Gene) Original kegg element: gene;13;hsa:1326
MAPK10GeneProduct422592 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK11GeneProduct417739 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK12GeneProduct769763 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK1GeneProduct373953 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
MAPK13GeneProduct771145 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK14GeneProduct421183 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK3GeneProductOriginal kegg element: gene;11;hsa:5594 hsa:5595
MAPK8GeneProduct423778 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK9GeneProduct395983 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MYD88GeneProduct420420 (Entrez Gene) Original kegg element: gene;47;hsa:4615
NFKB1GeneProduct396033 (Entrez Gene) Original kegg element: gene;14;hsa:4790
NFKB2GeneProduct386574 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
NFKBIAGeneProduct396093 (Entrez Gene) Original kegg element: gene;64;hsa:4792
PIK3CAGeneProduct424971 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CBGeneProduct424826 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CDGeneProduct419444 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CGGeneProduct417706 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R1GeneProduct427171 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R2GeneProduct771142 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R3GeneProduct429096 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R5GeneProduct417319 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
RAC1GeneProduct395871 (Entrez Gene) Original kegg element: gene;48;hsa:5879
RCJMB04_17b14GeneProduct430409 (Entrez Gene) Original kegg element: gene;21;hsa:3663
RCJMB04_17i9GeneProduct424044 (Entrez Gene) Original kegg element: gene;62;hsa:6772
RCJMB04_19h23GeneProduct423669 (Entrez Gene) Original kegg element: gene;42;hsa:1147
RCJMB04_8f10GeneProduct416496 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
RELAGeneProductOriginal kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
RIPK1GeneProduct378921 (Entrez Gene) Original kegg element: gene;17;hsa:8737
SPP1GeneProduct395210 (Entrez Gene) Original kegg element: gene;15;hsa:6696
TBK1GeneProduct417825 (Entrez Gene) Original kegg element: gene;52;hsa:29110
TICAM1GeneProduct100008585 (Entrez Gene) Original kegg element: gene;82;hsa:148022
TICAM2GeneProductOriginal kegg element: gene;80;hsa:353376
TIRAPGeneProduct419715 (Entrez Gene) Original kegg element: gene;83;hsa:114609
TLR1GeneProductOriginal kegg element: gene;75;hsa:7096
TLR2GeneProductOriginal kegg element: gene;74;hsa:7097
TLR3GeneProduct422720 (Entrez Gene) Original kegg element: gene;73;hsa:7098
TLR4GeneProduct417241 (Entrez Gene) Original kegg element: gene;79;hsa:7099
TLR5GeneProduct554217 (Entrez Gene) Original kegg element: gene;72;hsa:7100
TLR6GeneProduct771173 (Entrez Gene) Original kegg element: gene;76;hsa:10333
TLR7GeneProduct418638 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
TLR8GeneProductOriginal kegg element: gene;39;hsa:51284 hsa:51311
TLR9GeneProductOriginal kegg element: gene;78;hsa:54106
TNFGeneProductOriginal kegg element: gene;66;hsa:7124
TOLLIPGeneProduct423099 (Entrez Gene) Original kegg element: gene;81;hsa:54472
TRAF3GeneProduct423471 (Entrez Gene) Original kegg element: gene;16;hsa:7187
TRAF6GeneProduct423163 (Entrez Gene) Original kegg element: gene;53;hsa:7189

Annotated Interactions

No annotated interactions
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