Matrix Metalloproteinases (Gallus gallus)

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1Genes Dev 14:2123-2133GelatinasesStromelysinsPotential Inducers of TranscriptionMatrix metalloproteinases: effectors ofBased on Vu & Werb (2000)InhibitorsCollagenasesdevelopment and normal physiology.OtherMatrilysinMetalloelastaseEnamelysinMembrane-type MMPsMMP20MMP13TIMP4MMP8MMP11MMP17MMP23BMMP1MMP14TIMP1MMP21MMP16MMP24MMP23AMMP10MMP12MMP15MMP27TIMP2BSGMMP9MMP19MMP2TIMP3MMP25TNFMMP3MMP7MMP26MMP28TCF20


Description

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily.

Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense.

Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP129(r20953) with a 51% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Vu TH, Werb Z; ''Matrix metalloproteinases: effectors of development and normal physiology.''; Genes Dev, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
68814view17:16, 8 July 2013MaintBotUpdated to 2013 gpml schema
67454view11:04, 26 June 2013DdiglesOntology Term : 'cell-extracellular matrix signaling pathway' added !
40948view22:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35340view08:39, 12 February 2010ThomasModified description
35338view08:39, 12 February 2010Thomasmoved reference from comments to bibliography
33876view17:51, 9 December 2009MaintBotAutomatic update of empty xrefs
33494view15:11, 30 November 2009MaintBotRemoved group label
31541view21:49, 13 August 2009MaintBotFixed text labels
30392view21:06, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BSGGeneProduct770363 (Entrez Gene)
MMP10GeneProduct
MMP11GeneProduct769489 (Entrez Gene)
MMP12GeneProduct
MMP13GeneProduct772008 (Entrez Gene)
MMP1GeneProduct418982 (Entrez Gene)
MMP14GeneProduct426253 (Entrez Gene)
MMP15GeneProduct415629 (Entrez Gene)
MMP16GeneProduct396116 (Entrez Gene)
MMP17GeneProduct416801 (Entrez Gene)
MMP19GeneProduct
MMP20GeneProduct
MMP21GeneProduct
MMP2GeneProduct386583 (Entrez Gene)
MMP23AGeneProduct
MMP23BGeneProduct419407 (Entrez Gene)
MMP24GeneProduct419141 (Entrez Gene)
MMP25GeneProduct
MMP26GeneProduct
MMP27GeneProduct395850 (Entrez Gene)
MMP28GeneProduct417523 (Entrez Gene)
MMP3GeneProduct418981 (Entrez Gene)
MMP7GeneProduct418983 (Entrez Gene)
MMP8GeneProduct
MMP9GeneProduct395387 (Entrez Gene)
TCF20GeneProduct417980 (Entrez Gene)
TIMP1GeneProduct
TIMP2GeneProduct374178 (Entrez Gene)
TIMP3GeneProduct396483 (Entrez Gene)
TIMP4GeneProduct768711 (Entrez Gene)
TNFGeneProduct

Annotated Interactions

No annotated interactions
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