Wnt Signaling Pathway (Gallus gallus)

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1P-CateninTranscriptional ActivationApoptosisCytoskeletonRecruitment to UnknownUbiquitin TaggedB - Catenin26S Proteasome DegredationBNucleusPhosphorylatedFrizzled LigandsUbiquitin Conjugating EnzymeRCJMB04_5a10PRKCEWNT5AFZD8WNT2CCND2FZD2RHOARAC1FZD10FZD1WNT16WNT10BFRAT1WNT5BWNT7BCSNK1EJUNMAPK9FOSL1FZD9FZD5SFRP4LDLRWNT3GSK3BAXIN1WNT16PRKCHWNT10AFZD7PLAUFZD6PRKCGPAFAH1B1WNT2BPRKCQPPP2R5CRCJMB04_16p24WNT1DVL2WNT3AWNT7APRKCDPRKCZMYCFBXW2RCJMB04_12k21WNT11TCF-1/LEFCTNNB1WNT4CCND1MAPK10APCDVL3PRKCBCCND3FZD3WNT6RCJMB04_2d20PPP2R5E


Description

Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. Source: KEGG.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP428(r28695) with a 77% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Nusse R; ''Wnt signaling in disease and in development.''; Cell Res, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
109459view10:39, 18 March 2020L DupuisConverted interaction lines representing membrane to graphical lines
74236view09:30, 9 April 2014EgonwRemoved a data source where no ID was given.
68794view17:14, 8 July 2013MaintBotUpdated to 2013 gpml schema
67753view11:59, 26 June 2013DdiglesOntology Term : 'Wnt signaling pathway' added !
40926view22:51, 1 March 2011MaintBotRemoved redundant pathway information and comments
35126view13:37, 11 February 2010Thomasconnected line
35118view13:23, 11 February 2010Thomasadded literature
35108view13:15, 11 February 2010ThomasModified description
33857view17:44, 9 December 2009MaintBotAutomatic update of empty xrefs
33463view15:03, 30 November 2009MaintBotRemoved group label
31515view21:38, 13 August 2009MaintBotFixed text labels
30354view20:53, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APCGeneProduct415607 (Entrez Gene)
AXIN1GeneProduct395786 (Entrez Gene)
CCND1GeneProduct396341 (Entrez Gene)
CCND2GeneProduct374047 (Entrez Gene)
CCND3GeneProduct419928 (Entrez Gene)
CSNK1EGeneProduct378891 (Entrez Gene)
CTNNB1GeneProduct395964 (Entrez Gene)
DVL2GeneProduct
DVL3GeneProduct424949 (Entrez Gene)
FBXW2GeneProduct417088 (Entrez Gene)
FOSL1GeneProduct
FRAT1GeneProduct
FZD10GeneProduct373885 (Entrez Gene)
FZD1GeneProduct374062 (Entrez Gene)
FZD2GeneProduct374061 (Entrez Gene)
FZD3GeneProduct395572 (Entrez Gene)
FZD5GeneProduct374112 (Entrez Gene)
FZD6GeneProduct378788 (Entrez Gene)
FZD7GeneProduct374060 (Entrez Gene)
FZD8GeneProduct374059 (Entrez Gene)
FZD9GeneProduct373886 (Entrez Gene)
GSK3BGeneProduct418335 (Entrez Gene) MOUSE:KG38 MOUSE
JUNGeneProduct424673 (Entrez Gene)
LDLRGeneProduct395103 (Entrez Gene)
MAPK10GeneProduct422592 (Entrez Gene)
MAPK9GeneProduct395983 (Entrez Gene)
MYCGeneProduct420332 (Entrez Gene)
PAFAH1B1GeneProduct374224 (Entrez Gene)
PLAUGeneProduct396424 (Entrez Gene)
PPP2R5CGeneProduct423460 (Entrez Gene)
PPP2R5EGeneProduct423512 (Entrez Gene)
PRKCBGeneProduct416567 (Entrez Gene)
PRKCDGeneProduct415905 (Entrez Gene)
PRKCEGeneProduct421409 (Entrez Gene)
PRKCGGeneProduct
PRKCHGeneProduct423518 (Entrez Gene)
PRKCQGeneProduct
PRKCZGeneProduct419399 (Entrez Gene)
RAC1GeneProduct395871 (Entrez Gene)
RCJMB04_12k21GeneProduct423302 (Entrez Gene)
RCJMB04_16p24GeneProduct424991 (Entrez Gene)
RCJMB04_2d20GeneProduct419416 (Entrez Gene)
RCJMB04_5a10GeneProduct417430 (Entrez Gene)
RHOAGeneProduct395442 (Entrez Gene)
SFRP4GeneProduct420732 (Entrez Gene)
TCF-1/LEFGeneProduct
WNT1GeneProduct
WNT10AGeneProduct429040 (Entrez Gene)
WNT10BGeneProduct
WNT11GeneProduct395562 (Entrez Gene)
WNT16GeneProduct427856 (Entrez Gene)
WNT2GeneProduct417769 (Entrez Gene)
WNT2BGeneProduct374243 (Entrez Gene)
WNT3GeneProduct395396 (Entrez Gene)
WNT3AGeneProduct
WNT4GeneProduct395561 (Entrez Gene)
WNT5AGeneProduct395703 (Entrez Gene)
WNT5BGeneProduct418154 (Entrez Gene)
WNT6GeneProduct395235 (Entrez Gene)
WNT7AGeneProduct374168 (Entrez Gene)
WNT7BGeneProduct427937 (Entrez Gene)

Annotated Interactions

No annotated interactions
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