MAPK Signaling Pathway (Gallus gallus)

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1-8, 109Proliferation, differentiation,inflammationCellPhosphatidylinositolsignaling systemMAPKProliferation, inflammation, anti-apoptosisIP3DAGJNKERK5 pathwayLPSDNAPTPMAPKKKCa2+MAPKKDNA damageDNAHeteromeric G-proteinSerum, EGF,reactive oxygen species.or Srk tyrokinase downstreamDNADNATranscription factorsJNK & p38 MAP kinase pathwayWnt signaling pathwayp53 signaling pathwayDNAPTPClassical MAP kinase PathwayProliferation, differentiationMAPKKKKCycleSerum, cytotoxic drugs, irradiation,heatshock, reactive oxy speciesLPS and other stressApoptosisProliferation, differentiationMKPp38TRAF6NFKB1TGFB2MAP3K14MAP3K8MAPK12SOS2MAP2K1IKBKBEGFRMAPK8IP3RASA1PRKCDKRASMAP3K7ATF4NLKBDNFTRAF2MAP4K4RASGRF2MRASMAP4K1MAP3K4CD14AKT1TNFCDC25BRAP1APTPN5RASGRP4MAP2K4MAP3K13FASLGNTF5PRKCDFOSNF1TGFB3PRKCZGCKAKT3fgfrelk-1MOSPRKCHHSPA8MAP3K1CDC42PTPN5STMN1PDGFBGNA12CASP6TAOK1DUSP4TGFB1ATF4MEF2CNRASMAP3K7IP2TGFBR1SITPECRAF1DUSP1RPS6KA3FASACVR1CGRB2PTPN7ARRB1MEKK2/3EGFFLNAPLA2G10RASA2ARRB2Sap1aSTK3BRAFPDGFRBCRKATF2IL1BPPP3CCRAC1NGFBMAPK1CASP8ZAKPAK2HSPB2MINK1CASP9PRKCGIL1R2DUSP5RASGRP1MAP3K7IP1IL1AIL1R1CASP2MAP2K7RCJMB04_36h7MAPKAPK2MAPK9sap1aMAPK8MAPK4PLA2G5NR4A1MAP3K11MAPTMAP2K6PTPN7MAP2K2PPP3R1CASP1MAP4K3TMEM37PPM1AMAPK7PPP5CMAPK14PTPRRDUSP6RAP1BPAK1CASP3HSPA5MAP3K5CASP7JUNDMYCMAPKAPK5nfat2/4MAPK3RCJMB04_5i17MAPK10TP53MAP3K6PPP3CAPPP3R2msk1/2cAMPPRKCBmnk1/2TGFBR2MAP2K1IP1JUNMAP3K12HSPA1APPM1BTAOK2DUSP10ELK1PTPRRHSPB1SRFMAXNTRK1ACVR1BRAC2RCJMB04_24n15CRKLMAPK13AKT2PRKACAIKBKGFGF4DDIT3GADD45Amkk3DAXXDUSP7


Description

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org
 
This pathway was inferred from Homo sapiens pathway WP382(r28779) with a 65% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Zhu X, Lee HG, Raina AK, Perry G, Smith MA; ''The role of mitogen-activated protein kinase pathways in Alzheimer's disease.''; Neurosignals, 2002 PubMed Europe PMC
  2. Takeda K, Ichijo H; ''Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.''; Genes Cells, 2002 PubMed Europe PMC
  3. Tanoue T, Nishida E; ''Docking interactions in the mitogen-activated protein kinase cascades.''; Pharmacol Ther, 2002 PubMed Europe PMC
  4. Huang EJ, Reichardt LF; ''Trk receptors: roles in neuronal signal transduction.''; Annu Rev Biochem, 2003 PubMed Europe PMC
  5. Yang SH, Sharrocks AD, Whitmarsh AJ; ''Transcriptional regulation by the MAP kinase signaling cascades.''; Gene, 2003 PubMed Europe PMC
  6. Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y; ''Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.''; Toxicol Lett, 2003 PubMed Europe PMC
  7. Harper SJ, LoGrasso P; ''Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.''; Cell Signal, 2001 PubMed Europe PMC
  8. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH; ''MAP kinases.''; Chem Rev, 2001 PubMed Europe PMC
  9. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S; ''MAPK pathways in radiation responses.''; Oncogene, 2003 PubMed Europe PMC
  10. Abell AN, Granger DA, Johnson GL; ''MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.''; J Biol Chem, 2007 PubMed Europe PMC
  11. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL; ''(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.''; Cell Death Differ, 2012 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106113view12:01, 16 August 2019MaintBotHMDB identifier normalization
105689view21:00, 13 August 2019Khanspersremoved human-specific drug targeting and mutation
96344view09:30, 9 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95781view14:34, 19 January 2018MkutmonHomology conversion update
95119view15:03, 16 November 2017Mkutmonmissing homology converter comment source
95111view14:44, 16 November 2017DeSlFixed nested groups.
82861view14:48, 10 November 2015Mkutmoncorrected outdated identifiers
74228view15:24, 8 April 2014EgonwRemoved a data source where no ID was given.
68869view17:21, 8 July 2013MaintBotUpdated to 2013 gpml schema
67446view11:03, 26 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
47784view16:17, 6 April 2012Khanspersupdated xref
41008view22:57, 1 March 2011MaintBotRemoved redundant pathway information and comments
35665view22:30, 12 February 2010KhanspersDescription and lit refs
33929view18:10, 9 December 2009MaintBotAutomatic update of empty xrefs
33452view15:00, 30 November 2009MaintBotRemoved group label
31504view21:34, 13 August 2009MaintBotFixed text labels
30338view20:48, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACVR1BGeneProduct768878 (Entrez Gene)
ACVR1CGeneProduct424325 (Entrez Gene)
AKT1GeneProduct395928 (Entrez Gene)
AKT2GeneProduct373973 (Entrez Gene)
AKT3GeneProduct421497 (Entrez Gene)
ARRB1GeneProduct
ARRB2GeneProduct
ATF2GeneProduct395727 (Entrez Gene)
ATF4GeneProduct395693 (Entrez Gene)
BDNFGeneProduct396186 (Entrez Gene)
BRAFGeneProduct396239 (Entrez Gene)
CASP1GeneProduct395764 (Entrez Gene)
CASP2GeneProduct395857 (Entrez Gene)
CASP3GeneProduct395476 (Entrez Gene)
CASP6GeneProduct395477 (Entrez Gene)
CASP7GeneProduct423901 (Entrez Gene)
CASP8GeneProduct395284 (Entrez Gene)
CASP9GeneProduct426970 (Entrez Gene)
CD14GeneProduct100194427 (Entrez Gene)
CDC25BGeneProduct
CDC42GeneProduct395917 (Entrez Gene)
CRKGeneProduct417553 (Entrez Gene)
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DAXXGeneProduct
DDIT3GeneProduct
DUSP10GeneProduct421340 (Entrez Gene)
DUSP1GeneProduct374192 (Entrez Gene)
DUSP4GeneProduct395642 (Entrez Gene)
DUSP5GeneProduct423890 (Entrez Gene)
DUSP6GeneProduct374272 (Entrez Gene)
DUSP7GeneProduct
EGFGeneProduct408035 (Entrez Gene)
EGFRGeneProduct396494 (Entrez Gene)
ELK1GeneProduct
FASGeneProduct395274 (Entrez Gene)
FASLGGeneProduct776371 (Entrez Gene)
FGF4GeneProduct428857 (Entrez Gene)
FLNAGeneProduct
FOSGeneProduct396512 (Entrez Gene)
GADD45AGeneProduct693255 (Entrez Gene)
GCKGeneProduct374086 (Entrez Gene)
GNA12GeneProduct769924 (Entrez Gene)
GRB2GeneProduct386572 (Entrez Gene)
HSPA1AGeneProduct
HSPA5GeneProduct396487 (Entrez Gene)
HSPA8GeneProduct395853 (Entrez Gene)
HSPB1GeneProduct396227 (Entrez Gene)
HSPB2GeneProduct414136 (Entrez Gene)
IKBKBGeneProduct426792 (Entrez Gene)
IKBKGGeneProduct
IL1AGeneProduct
IL1BGeneProduct395196 (Entrez Gene)
IL1R1GeneProduct396481 (Entrez Gene)
IL1R2GeneProduct418715 (Entrez Gene)
JUNGeneProduct424673 (Entrez Gene)
JUNDGeneProduct
KRASGeneProduct418207 (Entrez Gene)
MAP2K1GeneProduct415549 (Entrez Gene)
MAP2K1IP1GeneProduct425210 (Entrez Gene)
MAP2K2GeneProduct396349 (Entrez Gene)
MAP2K4GeneProduct417312 (Entrez Gene)
MAP2K6GeneProduct
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MAP3K11GeneProduct
MAP3K12GeneProduct
MAP3K13GeneProduct424876 (Entrez Gene)
MAP3K1GeneProduct427144 (Entrez Gene)
MAP3K14GeneProduct419964 (Entrez Gene)
MAP3K4GeneProduct421579 (Entrez Gene)
MAP3K5GeneProduct421688 (Entrez Gene)
MAP3K6GeneProduct
MAP3K7GeneProduct421808 (Entrez Gene)
MAP3K7IP1GeneProduct418014 (Entrez Gene)
MAP3K7IP2GeneProduct421622 (Entrez Gene)
MAP3K8GeneProduct420479 (Entrez Gene)
MAP4K1GeneProduct
MAP4K3GeneProduct425965 (Entrez Gene)
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MAPK10GeneProduct422592 (Entrez Gene)
MAPK12GeneProduct769763 (Entrez Gene)
MAPK1GeneProduct373953 (Entrez Gene)
MAPK13GeneProduct771145 (Entrez Gene)
MAPK14GeneProduct421183 (Entrez Gene)
MAPK3GeneProduct
MAPK4GeneProduct
MAPK7GeneProduct
MAPK8GeneProduct423778 (Entrez Gene)
MAPK8IP3GeneProduct426986 (Entrez Gene)
MAPK9GeneProduct395983 (Entrez Gene)
MAPKAPK2GeneProduct419847 (Entrez Gene)
MAPKAPK5GeneProduct373929 (Entrez Gene)
MAPTGeneProduct426737 (Entrez Gene)
MAXGeneProduct
MEF2CGeneProduct769007 (Entrez Gene)
MEKK2/3GeneProduct
MINK1GeneProduct
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MRASGeneProduct395149 (Entrez Gene)
MYCGeneProduct420332 (Entrez Gene)
NF1GeneProduct396085 (Entrez Gene)
NFKB1GeneProduct396033 (Entrez Gene)
NGFBGeneProduct396466 (Entrez Gene)
NLKGeneProduct417669 (Entrez Gene)
NR4A1GeneProduct
NRASGeneProduct419885 (Entrez Gene)
NTF5GeneProduct
NTRK1GeneProduct396337 (Entrez Gene)
PAK1GeneProduct419083 (Entrez Gene)
PAK2GeneProduct424860 (Entrez Gene)
PDGFBGeneProduct374128 (Entrez Gene)
PDGFRBGeneProduct770488 (Entrez Gene)
PLA2G10GeneProduct418356 (Entrez Gene)
PLA2G5GeneProduct771655 (Entrez Gene)
PPM1AGeneProduct423525 (Entrez Gene)
PPM1BGeneProduct421404 (Entrez Gene)
PPP3CAGeneProduct395113 (Entrez Gene)
PPP3CCGeneProduct
PPP3R1GeneProduct378804 (Entrez Gene)
PPP3R2GeneProduct
PPP5CGeneProduct
PRKACAGeneProduct
PRKCBGeneProduct416567 (Entrez Gene)
PRKCDGeneProduct415905 (Entrez Gene)
PRKCGGeneProduct
PRKCHGeneProduct423518 (Entrez Gene)
PRKCZGeneProduct419399 (Entrez Gene)
PTPN5GeneProduct423085 (Entrez Gene)
PTPN7GeneProduct770905 (Entrez Gene)
PTPRRGeneProduct771985 (Entrez Gene)
RAC1GeneProduct395871 (Entrez Gene)
RAC2GeneProduct418044 (Entrez Gene)
RAF1GeneProduct396245 (Entrez Gene)
RAP1AGeneProduct419867 (Entrez Gene)
RAP1BGeneProduct417840 (Entrez Gene)
RASA1GeneProduct427327 (Entrez Gene)
RASA2GeneProduct424782 (Entrez Gene)
RASGRF2GeneProduct
RASGRP1GeneProduct423290 (Entrez Gene)
RASGRP4GeneProduct
RCJMB04_24n15GeneProduct378890 (Entrez Gene)
RCJMB04_36h7GeneProduct415557 (Entrez Gene)
RCJMB04_5i17GeneProduct415419 (Entrez Gene)
RPS6KA3GeneProduct418605 (Entrez Gene)
SITPECGeneProduct
SOS2GeneProduct423572 (Entrez Gene)
SRFGeneProduct396103 (Entrez Gene)
STK3GeneProduct
STMN1GeneProduct396057 (Entrez Gene)
Sap1aGeneProduct
TAOK1GeneProduct417583 (Entrez Gene)
TAOK2GeneProduct
TGFB1GeneProduct
TGFB2GeneProduct421352 (Entrez Gene)
TGFB3GeneProduct396438 (Entrez Gene)
TGFBR1GeneProduct374094 (Entrez Gene)
TGFBR2GeneProduct396399 (Entrez Gene)
TMEM37GeneProduct770956 (Entrez Gene)
TNFGeneProduct
TP53GeneProduct396200 (Entrez Gene)
TRAF2GeneProduct417287 (Entrez Gene)
TRAF6GeneProduct423163 (Entrez Gene)
ZAKGeneProduct424149 (Entrez Gene)
cAMPMetaboliteHMDB00058 (HMDB)
elk-1GeneProduct
fgfrGeneProduct
mkk3GeneProduct
mnk1/2GeneProduct
msk1/2GeneProduct
nfat2/4GeneProduct
sap1aGeneProduct

Annotated Interactions

No annotated interactions
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