Serotonin Receptor 2 and ELK-SRF/GATA4 signaling (Homo sapiens)

From WikiPathways

Revision as of 18:49, 12 July 2013 by MaintBot (Talk | contribs)
Jump to: navigation, search
62, 792, 56, 81, 10224932, 50, 65, 72, 76...57-60, 74, 80...3, 15, 17, 27, 42...21, 28, 40, 49, 7364, 8514, 965, 16, 18, 63, 70...77, 98252046, 1011, 7, 22, 31, 35...6, 19, 53, 82, 10613, 4811, 36, 41, 67, 88...8, 9210, 12, 71, 7529, 846633, 4526, 30, 38, 44, 554, 3410368, 8343, 6123, 8739, 47, 52, 69, 93...HTR2CGATA4HTR2AMAPK1ELK1SRFCALCIUM1,4,5-Insp3RASGRF1ITPR1HTR2BRASGRP1PLCserotoninMAPK3MAP2K1MAP2K2RAF1RasMAPKAPK2GNAQELK4


Description

This pathway is courtesy of Ariadne Genomics Pathway Studio.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Paine E, Palmantier R, Akiyama SK, Olden K, Roberts JD; ''Arachidonic acid activates mitogen-activated protein (MAP) kinase-activated protein kinase 2 and mediates adhesion of a human breast carcinoma cell line to collagen type IV through a p38 MAP kinase-dependent pathway.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  2. Damjanoska KJ, Van de Kar LD, Kindel GH, Zhang Y, D'Souza DN, Garcia F, Battaglia G, Muma NA; ''Chronic fluoxetine differentially affects 5-hydroxytryptamine (2A) receptor signaling in frontal cortex, oxytocin- and corticotropin-releasing factor-containing neurons in rat paraventricular nucleus.''; J Pharmacol Exp Ther, 2003 PubMed Europe PMC Scholia
  3. Sharp AH, Nucifora FC Jr, Blondel O, Sheppard CA, Zhang C, Snyder SH, Russell JT, Ryugo DK, Ross CA; ''Differential cellular expression of isoforms of inositol 1,4,5-triphosphate receptors in neurons and glia in brain.''; J Comp Neurol, 1999 PubMed Europe PMC Scholia
  4. Dougalis A, Lees G, Ganellin CR; ''The sleep inducing brain lipid cis-oleamide (cOA) does not modulate serotonergic transmission in the CA1 pyramidal neurons of the hippocampus in vitro.''; Neuropharmacology, 2004 PubMed Europe PMC Scholia
  5. Soroka V, Kiryushko D, Novitskaya V, Ronn LC, Poulsen FM, Holm A, Bock E, Berezin V; ''Induction of neuronal differentiation by a peptide corresponding to the homophilic binding site of the second Ig module of the neural cell adhesion molecule.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  6. Yu YL, Chiang YJ, Chen YC, Papetti M, Juo CG, Skoultchi AI, Yen JJ; ''MAPK-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  7. Yung Y, Yao Z, Aebersold DM, Hanoch T, Seger R; ''Altered regulation of ERK1b by MEK1 and PTP-SL and modified Elk1 phosphorylation by ERK1b are caused by abrogation of the regulatory C-terminal sequence of ERKs.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  8. Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR; ''PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  9. Mo Y, Ho W, Johnston K, Marmorstein R; ''Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex.''; J Mol Biol, 2001 PubMed Europe PMC Scholia
  10. Bأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½langer LF, Roy S, Tremblay M, Brott B, Steff AM, Mourad W, Hugo P, Erikson R, Charron J; ''Mek2 is dispensable for mouse growth and development.''; Mol Cell Biol, 2003 PubMed Europe PMC Scholia
  11. Boyarsky BK, Haque W, Rouleau MR, Hirschfeld RM; ''Sexual functioning in depressed outpatients taking mirtazapine.''; Depress Anxiety, 1999 PubMed Europe PMC Scholia
  12. Mattingly RR, Macara IG; ''Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits.''; Nature, 1996 PubMed Europe PMC Scholia
  13. Wall NR, Mohammad RM, Al-Katib AM; ''Mitogen-activated protein kinase is required for bryostatin 1-induced differentiation of the human acute lymphoblastic leukemia cell line Reh.''; Cell Growth Differ, 2001 PubMed Europe PMC Scholia
  14. Yang M, Gupta A, Shlykov SG, Corrigan R, Tsujimoto S, Sanborn BM; ''Multiple Trp isoforms implicated in capacitative calcium entry are expressed in human pregnant myometrium and myometrial cells.''; Biol Reprod, 2002 PubMed Europe PMC Scholia
  15. Bayguinov O, Hagen B, Sanders KM; ''Muscarinic stimulation increases basal Ca(2+) and inhibits spontaneous Ca(2+) transients in murine colonic myocytes.''; Am J Physiol Cell Physiol, 2001 PubMed Europe PMC Scholia
  16. Deszo EL, Brake DK, Cengel KA, Kelley KW, Freund GG; ''CD45 negatively regulates monocytic cell differentiation by inhibiting phorbol 12-myristate 13-acetate-dependent activation and tyrosine phosphorylation of protein kinase Cdelta.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  17. Felix JA, Chaban VV, Woodruff ML, Dirksen ER; ''Mechanical stimulation initiates intercellular Ca2+ signaling in intact tracheal epithelium maintained under normal gravity and simulated microgravity.''; Am J Respir Cell Mol Biol, 1998 PubMed Europe PMC Scholia
  18. Mochizuki N, Ohba Y, Kobayashi S, Otsuka N, Graybiel AM, Tanaka S, Matsuda M; ''Crk activation of JNK via C3G and R-Ras.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  19. Sananbenesi F, Fischer A, Schrick C, Spiess J, Radulovic J; ''Phosphorylation of hippocampal Erk-1/2, Elk-1, and p90-Rsk-1 during contextual fear conditioning: interactions between Erk-1/2 and Elk-1.''; Mol Cell Neurosci, 2002 PubMed Europe PMC Scholia
  20. Krump E, Sanghera JS, Pelech SL, Furuya W, Grinstein S; ''Chemotactic peptide N-formyl-met-leu-phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  21. Mikoshiba K; ''[IP3 receptor, a Ca2+ oscilator--role of IP3 receptor in development and neural plasticity]''; Nippon Yakurigaku Zasshi, 2002 PubMed Europe PMC Scholia
  22. Bai Y, Edamatsu H, Maeda S, Saito H, Suzuki N, Satoh T, Kataoka T; ''Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development.''; Cancer Res, 2004 PubMed Europe PMC Scholia
  23. Kerkelأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½ R, Pikkarainen S, Majalahti-Palviainen T, Tokola H, Ruskoaho H; ''Distinct roles of mitogen-activated protein kinase pathways in GATA-4 transcription factor-mediated regulation of B-type natriuretic peptide gene.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  24. Chen JJ, Li Z, Pan H, Murphy DL, Tamir H, Koepsell H, Gershon MD; ''Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters.''; J Neurosci, 2001 PubMed Europe PMC Scholia
  25. Bأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½camel C, Gavarini S, Chanrion B, Alonso G, Galأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½otti N, Dumuis A, Bockaert J, Marin P; ''The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  26. Chrestensen CA, Schroeder MJ, Shabanowitz J, Hunt DF, Pelo JW, Worthington MT, Sturgill TW; ''MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  27. Butts DA, Rokhsar DS; ''The information content of spontaneous retinal waves.''; J Neurosci, 2001 PubMed Europe PMC Scholia
  28. Mott HR, Carpenter JW, Zhong S, Ghosh S, Bell RM, Campbell SL; ''The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site.''; Proc Natl Acad Sci U S A, 1996 PubMed Europe PMC Scholia
  29. Uchida K, Miyauchi H, Furuichi T, Michikawa T, Mikoshiba K; ''Critical regions for activation gating of the inositol 1,4,5-trisphosphate receptor.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  30. Du JY, Ruan YC, Zuo WL, Yang ZH, Chen MH, Wu ZL, Xiang H, Zhou WL; ''Cellular mechanisms of carbachol-stimulated Cl- secretion in rat epididymal epithelium.''; Biol Reprod, 2006 PubMed Europe PMC Scholia
  31. LaVoie HA; ''The role of GATA in mammalian reproduction.''; Exp Biol Med (Maywood), 2003 PubMed Europe PMC Scholia
  32. Monno S, Newman MV, Cook M, Lowe WL Jr; ''Insulin-like growth factor I activates c-Jun N-terminal kinase in MCF-7 breast cancer cells.''; Endocrinology, 2000 PubMed Europe PMC Scholia
  33. Puente LG, Stone JC, Ostergaard HL; ''Evidence for protein kinase C-dependent and -independent activation of mitogen-activated protein kinase in T cells: potential role of additional diacylglycerol binding proteins.''; J Immunol, 2000 PubMed Europe PMC Scholia
  34. Li QJ, Vaingankar S, Sladek FM, Martins-Green M; ''Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression.''; Blood, 2000 PubMed Europe PMC Scholia
  35. Hetman M, Hsuan SL, Habas A, Higgins MJ, Xia Z; ''ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  36. Clarke LL, Harline MC, Otero MA, Glover GG, Garrad RC, Krugh B, Walker NM, Gonzأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½lez FA, Turner JT, Weisman GA; ''Desensitization of P2Y2 receptor-activated transepithelial anion secretion.''; Am J Physiol, 1999 PubMed Europe PMC Scholia
  37. Janknecht R, Hunter T; ''Convergence of MAP kinase pathways on the ternary complex factor Sap-1a.''; EMBO J, 1997 PubMed Europe PMC Scholia
  38. Piera MJ, Beaughard M, Michelin MT, Winslow E, Massingham R; ''Lack of efficacy of 5-HT2A receptor antagonists to reduce brain damage after 3 minutes of transient global cerebral ischaemia in gerbils.''; Fundam Clin Pharmacol, 1995 PubMed Europe PMC Scholia
  39. Zhou B, Zhang ZY; ''The activity of the extracellular signal-regulated kinase 2 is regulated by differential phosphorylation in the activation loop.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  40. Jacquet E, Vanoni M, Ferrari C, Alberghina L, Martegani E, Parmeggiani A; ''A mouse CDC25-like product enhances the formation of the active GTP complex of human ras p21 and Saccharomyces cerevisiae RAS2 proteins.''; J Biol Chem, 1992 PubMed Europe PMC Scholia
  41. Arozarena I, Matallanas D, Berciano MT, Sanz-Moreno V, Calvo F, Muأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½oz MT, Egea G, Lafarga M, Crespo P; ''Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors.''; Mol Cell Biol, 2004 PubMed Europe PMC Scholia
  42. Brunet A, Roux D, Lenormand P, Dowd S, Keyse S, Pouyssأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½gur J; ''Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry.''; EMBO J, 1999 PubMed Europe PMC Scholia
  43. Pikkarainen S, Tokola H, Kerkelأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½ R, Majalahti-Palviainen T, Vuolteenaho O, Ruskoaho H; ''Endothelin-1-specific activation of B-type natriuretic peptide gene via p38 mitogen-activated protein kinase and nuclear ETS factors.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  44. Caloca MJ, Zugaza JL, Bustelo XR; ''Exchange factors of the RasGRP family mediate Ras activation in the Golgi.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  45. Hassler M, Richmond TJ; ''The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex.''; EMBO J, 2001 PubMed Europe PMC Scholia
  46. Quilliam LA, Hisaka MM, Zhong S, Lowry A, Mosteller RD, Han J, Drugan JK, Broek D, Campbell SL, Der CJ; ''Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  47. Tanimura S, Nomura K, Ozaki K, Tsujimoto M, Kondo T, Kohno M; ''Prolonged nuclear retention of activated extracellular signal-regulated kinase 1/2 is required for hepatocyte growth factor-induced cell motility.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  48. Haverstick DM, Heady TN, Macdonald TL, Gray LS; ''Inhibition of human prostate cancer proliferation in vitro and in a mouse model by a compound synthesized to block Ca2+ entry.''; Cancer Res, 2000 PubMed Europe PMC Scholia
  49. Barry OP, Mullan B, Sheehan D, Kazanietz MG, Shanahan F, Collins JK, O'Sullivan GC; ''Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  50. Yanazume T, Hasegawa K, Morimoto T, Kawamura T, Wada H, Matsumori A, Kawase Y, Hirai M, Kita T; ''Cardiac p300 is involved in myocyte growth with decompensated heart failure.''; Mol Cell Biol, 2003 PubMed Europe PMC Scholia
  51. Sanna B, Bueno OF, Dai YS, Wilkins BJ, Molkentin JD; ''Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth.''; Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  52. Cameron AM, Steiner JP, Sabatini DM, Kaplin AI, Walensky LD, Snyder SH; ''Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux.''; Proc Natl Acad Sci U S A, 1995 PubMed Europe PMC Scholia
  53. Zippel R, Orecchia S, Sturani E, Martegani E; ''The brain specific Ras exchange factor CDC25 Mm: modulation of its activity through Gi-protein-mediated signals.''; Oncogene, 1996 PubMed Europe PMC Scholia
  54. Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Kjeldsen L, Shayman JA, Boxer LA; ''Sphingosine blocks human polymorphonuclear leukocyte phagocytosis through inhibition of mitogen-activated protein kinase activation.''; Blood, 1999 PubMed Europe PMC Scholia
  55. Paolucci L, Rozengurt E; ''Protein kinase D in small cell lung cancer cells: rapid activation through protein kinase C.''; Cancer Res, 1999 PubMed Europe PMC Scholia
  56. Vasilevskaya IA, O'Dwyer PJ; ''Effects of geldanamycin on signaling through activator-protein 1 in hypoxic HT29 human colon adenocarcinoma cells.''; Cancer Res, 1999 PubMed Europe PMC Scholia
  57. Nebigil CG, Jaffrأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½ F, Messaddeq N, Hickel P, Monassier L, Launay JM, Maroteaux L; ''Overexpression of the serotonin 5-HT2B receptor in heart leads to abnormal mitochondrial function and cardiac hypertrophy.''; Circulation, 2003 PubMed Europe PMC Scholia
  58. Suzaki Y, Yoshizumi M, Kagami S, Koyama AH, Taketani Y, Houchi H, Tsuchiya K, Takeda E, Tamaki T; ''Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  59. New L, Jiang Y, Han J; ''Regulation of PRAK subcellular location by p38 MAP kinases.''; Mol Biol Cell, 2003 PubMed Europe PMC Scholia
  60. Cussac D, Newman-Tancredi A, Duqueyroix D, Pasteau V, Millan MJ; ''Differential activation of Gq/11 and Gi(3) proteins at 5-hydroxytryptamine(2C) receptors revealed by antibody capture assays: influence of receptor reserve and relationship to agonist-directed trafficking.''; Mol Pharmacol, 2002 PubMed Europe PMC Scholia
  61. Venkatasubbarao K, Choudary A, Freeman JW; ''Farnesyl transferase inhibitor (R115777)-induced inhibition of STAT3(Tyr705) phosphorylation in human pancreatic cancer cell lines require extracellular signal-regulated kinases.''; Cancer Res, 2005 PubMed Europe PMC Scholia
  62. Coxon PY, Rane MJ, Uriarte S, Powell DW, Singh S, Butt W, Chen Q, McLeish KR; ''MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils.''; Cell Signal, 2003 PubMed Europe PMC Scholia
  63. Guha M, O'Connell MA, Pawlinski R, Hollis A, McGovern P, Yan SF, Stern D, Mackman N; ''Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression.''; Blood, 2001 PubMed Europe PMC Scholia
  64. Heidenreich O, Neininger A, Schratt G, Zinck R, Cahill MA, Engel K, Kotlyarov A, Kraft R, Kostka S, Gaestel M, Nordheim A; ''MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  65. Cox DA, Watts SW, Cohen ML; ''Neomycin selectively inhibits 5-hydroxytryptamine-induced contraction in the guinea pig trachea.''; J Pharmacol Exp Ther, 1996 PubMed Europe PMC Scholia
  66. Purcell NH, Darwis D, Bueno OF, Mأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½ller JM, Schأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½le R, Molkentin JD; ''Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes.''; Mol Cell Biol, 2004 PubMed Europe PMC Scholia
  67. Bakovic M, Waite K, Vance DE; ''Oncogenic Ha-Ras transformation modulates the transcription of the CTP:phosphocholine cytidylyltransferase alpha gene via p42/44MAPK and transcription factor Sp3.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  68. Li Q, Muma NA, Battaglia G, Van de Kar LD; ''Fluoxetine gradually increases [125I]DOI-labelled 5-HT2A/2C receptors in the hypothalamus without changing the levels of Gq- and G11-proteins.''; Brain Res, 1997 PubMed Europe PMC Scholia
  69. Gosmanov AR, Wong JA, Thomason DB; ''Duality of G protein-coupled mechanisms for beta-adrenergic activation of NKCC activity in skeletal muscle.''; Am J Physiol Cell Physiol, 2002 PubMed Europe PMC Scholia
  70. Lum H, Roebuck KA; ''Oxidant stress and endothelial cell dysfunction.''; Am J Physiol Cell Physiol, 2001 PubMed Europe PMC Scholia
  71. Cobb MH, Goldsmith EJ; ''How MAP kinases are regulated.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  72. Ben-Levy R, Leighton IA, Doza YN, Attwood P, Morrice N, Marshall CJ, Cohen P; ''Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.''; EMBO J, 1995 PubMed Europe PMC Scholia
  73. Ravanti L, Heino J, Lأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½pez-Otأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½n C, Kأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½hأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½ri VM; ''Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  74. Rambaratsingh RA, Stone JC, Blumberg PM, Lorenzo PS; ''RasGRP1 represents a novel non-protein kinase C phorbol ester signaling pathway in mouse epidermal keratinocytes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  75. Chen DB, Westfall SD, Fong HW, Roberson MS, Davis JS; ''Prostaglandin F2alpha stimulates the Raf/MEK1/mitogen-activated protein kinase signaling cascade in bovine luteal cells.''; Endocrinology, 1998 PubMed Europe PMC Scholia
  76. Imada-Shirakata Y, Kotera T, Ueda S, Okuma M; ''Serotonin activates electrolyte transport via 5-HT2A receptor in rat colonic crypt cells.''; Biochem Biophys Res Commun, 1997 PubMed Europe PMC Scholia
  77. Guilbault B, Kay RJ; ''RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  78. Chung KC, Sung JY, Ahn W, Rhim H, Oh TH, Lee MG, Ahn YS; ''Intracellular calcium mobilization induces immediate early gene pip92 via Src and mitogen-activated protein kinase in immortalized hippocampal cells.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  79. Hأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½ser M, Luckett J, Chiloeches A, Mercer K, Iwobi M, Giblett S, Sun XM, Brown J, Marais R, Pritchard C; ''MEK kinase activity is not necessary for Raf-1 function.''; EMBO J, 2001 PubMed Europe PMC Scholia
  80. Zhong XP, Hainey EA, Olenchock BA, Zhao H, Topham MK, Koretzky GA; ''Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  81. Budnik LT, Brunswig-Spickenheier B, Mukhopadhyay AK; ''Lysophosphatidic acid signals through mitogen-activated protein kinase-extracellular signal regulated kinase in ovarian theca cells expressing the LPA1/edg2-receptor: involvement of a nonclassical pathway?''; Mol Endocrinol, 2003 PubMed Europe PMC Scholia
  82. Tao J, Sanghera JS, Pelech SL, Wong G, Levy JG; ''Stimulation of stress-activated protein kinase and p38 HOG1 kinase in murine keratinocytes following photodynamic therapy with benzoporphyrin derivative.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  83. Yuryev A, Wennogle LP; ''The RAF family: an expanding network of post-translational controls and protein-protein interactions.''; Cell Res, 1998 PubMed Europe PMC Scholia
  84. Yang E, Lerner L, Besser D, Darnell JE Jr; ''Independent and cooperative activation of chromosomal c-fos promoter by STAT3.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  85. Tao FC, Tolloczko B, Mitchell CA, Powell WS, Martin JG; ''Inositol (1,4,5)trisphosphate metabolism and enhanced calcium mobilization in airway smooth muscle of hyperresponsive rats.''; Am J Respir Cell Mol Biol, 2000 PubMed Europe PMC Scholia
  86. Tremblay JJ, Hamel F, Viger RS; ''Protein kinase A-dependent cooperation between GATA and CCAAT/enhancer-binding protein transcription factors regulates steroidogenic acute regulatory protein promoter activity.''; Endocrinology, 2002 PubMed Europe PMC Scholia
  87. Morgan MA, Dolp O, Reuter CW; ''Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling.''; Blood, 2001 PubMed Europe PMC Scholia
  88. Goppelt-Struebe M, Stroebel M; ''Mechanisms of serotonin-induced Ca2+ responses in mesangial cells.''; Naunyn Schmiedebergs Arch Pharmacol, 1997 PubMed Europe PMC Scholia
  89. Schoenbaum G, Chiba AA, Gallagher M; ''Neural encoding in orbitofrontal cortex and basolateral amygdala during olfactory discrimination learning.''; J Neurosci, 1999 PubMed Europe PMC Scholia
  90. Buchsbaum R, Telliez JB, Goonesekera S, Feig LA; ''The N-terminal pleckstrin, coiled-coil, and IQ domains of the exchange factor Ras-GRF act cooperatively to facilitate activation by calcium.''; Mol Cell Biol, 1996 PubMed Europe PMC Scholia
  91. Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Quon MJ, Reed BC, Dikic I, Farese RV; ''Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  92. Nitsch RM, Deng M, Growdon JH, Wurtman RJ; ''Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  93. Waas WF, Dalby KN; ''Transient protein-protein interactions and a random-ordered kinetic mechanism for the phosphorylation of a transcription factor by extracellular-regulated protein kinase 2.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  94. Enarsson M, Erlandsson A, Larsson H, Forsberg-Nilsson K; ''Extracellular signal-regulated protein kinase signaling is uncoupled from initial differentiation of central nervous system stem cells to neurons.''; Mol Cancer Res, 2002 PubMed Europe PMC Scholia
  95. Shi CS, Leonardi A, Kyriakis J, Siebenlist U, Kehrl JH; ''TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related.''; J Immunol, 1999 PubMed Europe PMC Scholia
  96. Nonner D, Barrett EF, Barrett JN; ''Brief exposure to neurotrophins produces a calcium-dependent increase in choline acetyltransferase activity in cultured rat septal neurons.''; J Neurochem, 2000 PubMed Europe PMC Scholia
  97. Nebigil CG, Etienne N, Messaddeq N, Maroteaux L; ''Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B receptor signaling.''; FASEB J, 2003 PubMed Europe PMC Scholia
  98. Engel K, Schultz H, Martin F, Kotlyarov A, Plath K, Hahn M, Heinemann U, Gaestel M; ''Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  99. Toki S, Kawasaki H, Tashiro N, Housman DE, Graybiel AM; ''Guanine nucleotide exchange factors CalDAG-GEFI and CalDAG-GEFII are colocalized in striatal projection neurons.''; J Comp Neurol, 2001 PubMed Europe PMC Scholia
  100. Lurtz MM, Louis CF; ''Calmodulin and protein kinase C regulate gap junctional coupling in lens epithelial cells.''; Am J Physiol Cell Physiol, 2003 PubMed Europe PMC Scholia
  101. Ebinu JO, Stang SL, Teixeira C, Bottorff DA, Hooton J, Blumberg PM, Barry M, Bleakley RC, Ostergaard HL, Stone JC; ''RasGRP links T-cell receptor signaling to Ras.''; Blood, 2000 PubMed Europe PMC Scholia
  102. Yan C, Kim D, Aizawa T, Berk BC; ''Functional interplay between angiotensin II and nitric oxide: cyclic GMP as a key mediator.''; Arterioscler Thromb Vasc Biol, 2003 PubMed Europe PMC Scholia
  103. Garcأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½a KD, Shah T, Garcأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½a J; ''Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice.''; Am J Physiol Cell Physiol, 2004 PubMed Europe PMC Scholia
  104. Ryder JW, Fahlman R, Wallberg-Henriksson H, Alessi DR, Krook A, Zierath JR; ''Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  105. Morimoto T, Hasegawa K, Kaburagi S, Kakita T, Wada H, Yanazume T, Sasayama S; ''Phosphorylation of GATA-4 is involved in alpha 1-adrenergic agonist-responsive transcription of the endothelin-1 gene in cardiac myocytes.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  106. Suttles J, Milhorn DM, Miller RW, Poe JC, Wahl LM, Stout RD; ''CD40 signaling of monocyte inflammatory cytokine synthesis through an ERK1/2-dependent pathway. A target of interleukin (il)-4 and il-10 anti-inflammatory action.''; J Biol Chem, 1999 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106487view21:40, 4 September 2019KhanspersModified description
105809view22:54, 15 August 2019KhanspersModified description
101994view19:25, 22 November 2018EgonwRemoved whitespace in PubMed identifiers.
101953view21:03, 20 November 2018EgonwRemoved whitespace in PubMed identifiers.
80010view13:49, 30 April 2015ZariAnnotated RAS gene
74437view06:40, 20 April 2014EgonwRemoved brackets and text from PubMed IDs, e.g. "9016798 (Tis" changed to "9016798".
70101view18:49, 12 July 2013MaintBotupdating to 2013 schema
49572view05:46, 21 July 2012AndraRDF Tidy
49546view10:22, 20 July 2012AndraRDF Tidy
46088view02:25, 15 December 2011AllanKuchinskyupdated HCNC IDs
45038view18:51, 6 October 2011ThomasOntology Term : 'neuron' added !
45026view18:44, 6 October 2011ThomasOntology Term : 'serotonin signaling pathway' added !
41122view23:37, 1 March 2011MaintBotRemoved redundant pathway information and comments
39766view07:53, 17 January 2011AlexanderPico
34476view18:35, 10 December 2009MaintBotAutomatic update of empty xrefs
33186view18:02, 5 November 2009KhanspersModified categories
31149view03:55, 5 August 2009ArukeModified description
30213view22:12, 14 July 2009ArukeUpdated all interactions
30212view20:41, 14 July 2009ArukeSpecify description
30211view20:32, 14 July 2009ArukeUpdated node properties
30210view19:57, 14 July 2009ArukeSpecify description
30207view19:07, 14 July 2009ArukeSpecify description
30206view18:38, 14 July 2009ArukeNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,4,5-Insp3Metabolite85166-31-0 (CAS) 1,4,5-Insp3
CALCIUMMetabolite7440-70-2 (CAS)
ELK1GeneProduct2002 (Entrez Gene) ELK1, member of ETS oncogene family
ELK4GeneProduct2005 (Entrez Gene) ETS domain-containing protein Elk-4 (SRF accessory protein 1)
GATA4GeneProduct2626 (Entrez Gene) GATA-binding protein 4/5/6
GNAQGeneProduct2776 (Entrez Gene) guanine nucleotide binding protein, alpha q polypeptide
HTR2AGeneProduct3356 (Entrez Gene) 5-hydroxytryptamine (serotonin) receptor 2A
HTR2BGeneProduct3357 (Entrez Gene) 5-hydroxytryptamine (serotonin) receptor 2B
HTR2CGeneProduct3358 (Entrez Gene) 5-hydroxytryptamine (serotonin) receptor 2C
ITPR1GeneProduct3708 (Entrez Gene) inositol 1,4,5-triphosphate receptor 1
MAP2K1GeneProduct5604 (Entrez Gene) mitogen activated protein kinase kinase 1
MAP2K2GeneProduct5605 (Entrez Gene) mitogen activated protein kinase kinase 2
MAPK1GeneProductMAPK1 (HGNC) mitogen activated protein kinase 1
MAPK3GeneProduct5595 (Entrez Gene) mitogen activated protein kinase 3
MAPKAPK2GeneProduct9261 (Entrez Gene) MAP kinase-activated protein kinase 2
PLCProteinphospholipase C group
RAF1GeneProduct5894 (Entrez Gene) v-raf-leukemia viral oncogene 1
RASGRF1GeneProduct5923 (Entrez Gene) RAS protein-specific guanine nucleotide-releasing factor 1
RASGRP1GeneProduct10125 (Entrez Gene) RAS guanyl releasing protein 1
RasProteinRAS oncogene homolog group
SRFGeneProduct6722 (Entrez Gene) serum response factor
serotoninMetabolite50-67-9 (CAS)

Annotated Interactions

No annotated interactions

Personal tools