T-Cell antigen Receptor (TCR) Signaling Pathway (Homo sapiens)

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Endoplasmic reticulumNucleusNU->CYCytoplasmAccession Number: NetPath_11DMolecular associationSumoylationProteolytic cleavageECAutophosphorylationCY->NUProteins in a complex interactionGODephosphorylationMolecule in the pathwayMTLigandMitochondrionActivationDesumoylationReaction through unknown mechanisms/moleculesNUDERRecruitmentDemethylationPMControlCYInhibitionReceptorTranslocationAcetylationGene SymbolEnzyme complexEndosomeExtracellularAntigenPlasma membranePalmitoylationUbiquitinationMethylation(Protein-protein interaction)DeacetylationGlycosylationCY->NUGolgi apparatusENPhosphorylationDeubiquitinationCY->PMSH2D2ACD3GDTX1DUSP3CRKSTAT5BCD3EARHGDIBJUNPRKCQCREBBPSTAT1PIK3R2CRKLRIPK2CBLBFOSPTK2VAV2CREB1DBNLRAP1AFYBSRCITKCD8AMAPK7SOS1DOCK2AKT1WASPIPNCK1MAP2K2STK39PTPN6TUBBPRKD2PTK2BSH3BP2MAPK1LNKSH2D3CLCP2CD4PTPRCPSTPIP1NCLNFATC2MAPK3GIT2GRAPFYNYWHAQDEF6SLARASA1SYKSTAT5BCD3ZCTNNB1CD3DSHBCISHSCAP2HOMER3CD5ARHGEF6LATNEDD9PTPN11DNM2WASABL1MUC1ACP1STAT5AABI1SOS2BRAFLIME1PIK3R1CABIN1CD3ZPTPRJMAP4K1PTPRHRASGRP2SLA2LAX1CDC42RAPGEF1MAP3K1CARD11PTPN22VAV3NFAM1JAK3FYBARHGEF7LCKNCK1PAK1EVLGRB2SHC1TUBA1PXNVASPDLG1FCRL3RAC2SIT1PAG1MAP2K1PTPN3LYNGAB2STAT5AGRAP2TRAT1ITPR1PTPN12LCP2CD2APHDAC7AENAHVAV1UNC119CBLBCL10JUNCD3ETRA@ZAP70PLCG1TRB@CD2TXKPPP3CBCEBPBHDAC7AWASF2KHDRBS1SCAP1LIME1


Description

No description

Comments

GenMAPP notes 
NetPath_11 - T Cell Receptor Signaling Pathway NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
103503view17:45, 7 March 2019AlexanderPicoFixed Entrez ID for LCK
97623view07:50, 31 May 2018AMTanOntology Term : 'T cell' added !
89937view13:49, 6 October 2016MkutmonModified description
86031view12:16, 28 June 2016EveloModified title
84986view18:55, 4 April 2016AlexanderPicoreplaced mim-conversion with arrow for generic
79955view12:06, 28 April 2015Zarichanged Entrez gene Id to Ensembl Id for MAP3K14
79954view12:05, 28 April 2015ZariChanged Entrez gene Id to Ensembl Id
72111view22:22, 24 October 2013AlexanderPicoadded missing database to xref
70116view19:14, 12 July 2013MaintBotupdated to 2013 schema
48452view16:31, 24 May 2012NetPathModified description
48451view16:27, 24 May 2012NetPathModified description
45093view21:13, 6 October 2011KhanspersOntology Term : 'T cell receptor signaling pathway' added !
44619view17:47, 22 September 2011KhanspersUpdating content to NetSlim
41061view23:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
20823view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:T-Cell-Receptor NetPath 11]] moved to [[Pathway:WP69]]: Moved to stable identifier
11464view11:13, 1 April 2008ThomasModified categories
11159view10:30, 22 March 2008MaintBotNew page: 8426view13:46, 7 January 2008MaintBot[[Pathway:Human:T-Cell-Receptor NetPath 11]] moved to [[Pathway:Homo sapiens:T-Cell-Receptor NetPath 11]]: Renaming species
7830view16:20, 18 December 2007MaintBotfixed category names
7298view12:42, 4 November 2007MaintBotAdded categories to GPML
6396view22:18, 22 May 2007A.Pandeygpml file for [[Human:T-Cell-Receptor_NetPath_11]]

External references

DataNodes

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NameTypeDatabase referenceComment
ABI1GeneProduct10006 (Entrez Gene)
ABL1GeneProduct25 (Entrez Gene)
ACP1GeneProduct52 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
ARHGDIBGeneProduct397 (Entrez Gene)
ARHGEF6GeneProduct9459 (Entrez Gene)
ARHGEF7GeneProduct8874 (Entrez Gene)
BCL10GeneProduct8915 (Entrez Gene)
BRAFGeneProduct673 (Entrez Gene)
CABIN1GeneProduct23523 (Entrez Gene)
CARD11GeneProduct84433 (Entrez Gene)
CBLGeneProduct867 (Entrez Gene)
CBLBGeneProduct868 (Entrez Gene)
CD2GeneProduct914 (Entrez Gene)
CD2APGeneProduct23607 (Entrez Gene)
CD3DGeneProduct915 (Entrez Gene)
CD3EGeneProduct916 (Entrez Gene)
CD3GGeneProduct917 (Entrez Gene)
CD3ZGeneProduct919 (Entrez Gene)
CD4GeneProduct920 (Entrez Gene)
CD5GeneProduct921 (Entrez Gene)
CD8AGeneProduct925 (Entrez Gene)
CDC42GeneProduct998 (Entrez Gene)
CEBPBGeneProduct1051 (Entrez Gene)
CISHGeneProduct1154 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
CREBBPGeneProduct1387 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
CRKLGeneProduct1399 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
DBNLGeneProduct28988 (Entrez Gene)
DEF6GeneProduct50619 (Entrez Gene)
DLG1GeneProduct1739 (Entrez Gene)
DNM2GeneProduct1785 (Entrez Gene)
DOCK2GeneProduct1794 (Entrez Gene)
DTX1GeneProduct1840 (Entrez Gene)
DUSP3GeneProduct1845 (Entrez Gene)
ENAHGeneProduct55740 (Entrez Gene)
EVLGeneProduct51466 (Entrez Gene)
FCRL3GeneProduct115352 (Entrez Gene)
FOSGeneProduct2353 (Entrez Gene)
FYBGeneProduct2533 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene)
GAB2GeneProduct9846 (Entrez Gene)
GIT2GeneProduct9815 (Entrez Gene)
GRAPGeneProduct10750 (Entrez Gene)
GRAP2GeneProduct9402 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
HDAC7AGeneProduct51564 (Entrez Gene)
HOMER3GeneProduct9454 (Entrez Gene)
ITKGeneProduct3702 (Entrez Gene)
ITPR1GeneProduct3708 (Entrez Gene)
JAK3GeneProduct3718 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
KHDRBS1GeneProduct10657 (Entrez Gene)
LATGeneProduct27040 (Entrez Gene)
LAX1GeneProduct54900 (Entrez Gene)
LCKGeneProduct3932 (Entrez Gene)
LCP2GeneProduct3937 (Entrez Gene)
LIME1GeneProduct54923 (Entrez Gene)
LNKGeneProduct10019 (Entrez Gene)
LYNGeneProduct4067 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MAP4K1GeneProduct11184 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK7GeneProduct5598 (Entrez Gene)
MUC1GeneProduct4582 (Entrez Gene)
NCK1GeneProduct4690 (Entrez Gene)
NCLGeneProduct4691 (Entrez Gene)
NEDD9GeneProduct4739 (Entrez Gene)
NFAM1GeneProduct150372 (Entrez Gene)
NFATC2GeneProduct4773 (Entrez Gene)
PAG1GeneProduct55824 (Entrez Gene)
PAK1GeneProduct5058 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PLCG1GeneProduct5335 (Entrez Gene)
PPP3CBGeneProduct5532 (Entrez Gene)
PRKCQGeneProduct5588 (Entrez Gene)
PRKD2GeneProduct25865 (Entrez Gene)
PSTPIP1GeneProduct9051 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene)
PTK2BGeneProduct2185 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PTPN12GeneProduct5782 (Entrez Gene)
PTPN22GeneProduct26191 (Entrez Gene)
PTPN3GeneProduct5774 (Entrez Gene)
PTPN6GeneProduct5777 (Entrez Gene)
PTPRCGeneProduct5788 (Entrez Gene)
PTPRHGeneProduct5794 (Entrez Gene)
PTPRJGeneProduct5795 (Entrez Gene)
PXNGeneProduct5829 (Entrez Gene)
RAC2GeneProduct5880 (Entrez Gene)
RAP1AGeneProduct5906 (Entrez Gene)
RAPGEF1GeneProduct2889 (Entrez Gene)
RASA1GeneProduct5921 (Entrez Gene)
RASGRP2GeneProduct10235 (Entrez Gene)
RIPK2GeneProduct8767 (Entrez Gene)
SCAP1GeneProduct8631 (Entrez Gene)
SCAP2GeneProduct8935 (Entrez Gene)
SH2D2AGeneProduct9047 (Entrez Gene)
SH2D3CGeneProduct10044 (Entrez Gene)
SH3BP2GeneProduct6452 (Entrez Gene)
SHBGeneProduct6461 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SIT1GeneProduct27240 (Entrez Gene)
SLA2GeneProduct84174 (Entrez Gene)
SLAGeneProduct6503 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SOS2GeneProduct6655 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT5AGeneProduct6776 (Entrez Gene)
STAT5BGeneProduct6777 (Entrez Gene)
STK39GeneProduct27347 (Entrez Gene)
SYKGeneProduct6850 (Entrez Gene)
TRA@GeneProduct6955 (Entrez Gene)
TRAT1GeneProduct50852 (Entrez Gene)
TRB@GeneProduct6957 (Entrez Gene)
TUBA1GeneProduct7277 (Entrez Gene)
TUBBGeneProduct203068 (Entrez Gene)
TXKGeneProduct7294 (Entrez Gene)
UNC119GeneProduct9094 (Entrez Gene)
VASPGeneProduct7408 (Entrez Gene)
VAV1GeneProduct7409 (Entrez Gene)
VAV2GeneProduct7410 (Entrez Gene)
VAV3GeneProduct10451 (Entrez Gene)
WASGeneProduct7454 (Entrez Gene)
WASF2GeneProduct10163 (Entrez Gene)
WASPIPGeneProduct7456 (Entrez Gene)
YWHAQGeneProduct10971 (Entrez Gene)
ZAP70GeneProduct7535 (Entrez Gene)

Annotated Interactions

No annotated interactions
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