ErbB Signaling Pathway (Homo sapiens)

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Error rendering pathway page

This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.

Pathway history

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110910view22:18, 19 June 2020Khanspersfixed unconnected interaction
108898view19:18, 5 February 2020Khanspersupdated label for EIF4EBP1
108897view19:16, 5 February 2020Khanspersadded phosphosite to eiF-4EBP
108887view23:14, 4 February 2020Khanspersupdated phosphosite
108882view19:45, 4 February 2020Khanspersupdated ligand binding
108881view19:42, 4 February 2020Khanspersupdated ERBBs as complexes
108880view19:41, 4 February 2020Khansperstest
108831view00:20, 1 February 2020Khanspersupdated interaction with PDPK1
108769view02:13, 29 January 2020Khanspersfinal touches
108765view01:32, 29 January 2020Khanspersmore phosphosites
108761view01:12, 29 January 2020Khanspersupdated to official symbols
108760view01:10, 29 January 2020Khanspersupdated xref for PDK1 (PDPK1)
108759view22:53, 28 January 2020Khanspersadded phosphosites and updated node sizing and layout
108758view19:00, 28 January 2020Khanspersadded phosphosites for MAPK8/9/10
108757view17:43, 28 January 2020Khanspersupdated MEK/ERK
108752view05:58, 28 January 2020Khanspersadded phosphosites
108751view05:29, 28 January 2020Khanspersadded phospho sites
108750view05:05, 28 January 2020Khanspersupdated phospho sites
108749view01:19, 28 January 2020KhanspersAdding phosphosites
108748view00:50, 28 January 2020Khanspersadded phosphosite
108747view22:11, 27 January 2020KhanspersAdded phospho sites
108256view14:22, 3 December 2019L DupuisConnected unconnected lines
108194view10:56, 29 November 2019FehrhartOntology Term : 'multiple sclerosis' added !
108193view10:56, 29 November 2019FehrhartOntology Term : 'Alzheimer's disease' added !
108192view10:56, 29 November 2019FehrhartOntology Term : 'cancer' added !
106821view13:30, 17 September 2019MaintBotHMDB identifier normalization
106405view21:33, 28 August 2019KhanspersModified description
105438view04:50, 8 August 2019KhanspersModified description
105003view04:54, 28 June 2019KhanspersModified description
102179view23:07, 5 December 2018Ejaehnigfurther improved alignment of nodes
102176view22:36, 5 December 2018Ejaehnigimproved alignment of nodes in groups
102175view22:18, 5 December 2018EjaehnigThis pathway was ported from KEGG, but the KEGG pathway used a single protein node for multiple genes in many cases. For these nodes, I split the node into groups containing all of the genes underlying each node in the KEGG pathway (interchangeable genes
98355view05:36, 24 August 2018EgonwUpdated the MIR21 identifier.
96366view07:28, 10 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
94739view15:06, 5 October 2017Mkutmonfix unconnected line
91869view22:17, 31 March 2017KhanspersModified description
91868view22:13, 31 March 2017Khanspersupdated phosphorylation states, interactions, metabolites, cell components etc
86901view07:59, 14 July 2016MkutmonOntology Term : 'oxidative phosphorylation pathway' added !
86900view07:59, 14 July 2016MkutmonOntology Term : 'PW:0000034' removed !
80202view19:32, 22 May 2015Khanspersadded mir21 targeting of ERBB2 and MYC
69914view19:37, 11 July 2013AlexanderPicoModified title
68012view07:32, 29 June 2013EgonwAdded a missing metabolite identifier.
67205view10:20, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
63184view20:44, 8 May 2013MaintBotUpdating gpml version
41091view23:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
38179view04:20, 22 August 2010AlexanderPicoConverted pathway objects
38178view04:16, 22 August 2010AlexanderPicoAdded literature references
38177view04:10, 22 August 2010AlexanderPicoConverted pathway objects
38176view04:01, 22 August 2010AlexanderPicoSpecify description
38175view03:59, 22 August 2010AlexanderPicoAdded reference and more EGFR connections

Error details

exception 'MWException' with message 'Invalid pvjson, so cannot savePvjsonCache.' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1278
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(584): Pathway->savePvjsonCache()
#1 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(282): Pathway->getPvjson()
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(167): PathwayPage->Diagram()
#3 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(24): PathwayPage->render()
#4 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#5 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#6 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#7 /var/www/wikipathways/includes/Article.php(3406): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 29836)
#8 /var/www/wikipathways/includes/Article.php(875): Article->outputWikiText('<?xml version="...', false)
#9 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#10 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#11 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#12 {main}
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