miR-1 in cardiac development (Mus musculus)

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1Electric conductionmiR-1Heart morphogenesisHand2Irx5mmu-mir-1-1Kcnd2mmu-mir-1-2


This pathway is an adaptation from figure 2.a in Stefani et al. (2008). miR-1 regulates cardiac morphogenesis by optimizing the level of the HAND2 transcription factor. Electric conduction is abnormal in mice that lack miR-1 as a consequence of de-inhibition of IRX5, a homeodomain-containing transcription factor that represses the expression of the KCND2 potassium channel.

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Ontology Terms



  1. Stefani G, Slack FJ; ''Small non-coding RNAs in animal development.''; Nat Rev Mol Cell Biol, 2008 PubMed Europe PMC Scholia


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69184view18:22, 8 July 2013MaintBotUpdated to 2013 gpml schema
67465view11:05, 26 June 2013DdiglesOntology Term : 'microRNA pathway' added !
41375view00:28, 2 March 2011MaintBotRemoved redundant pathway information and comments
32165view14:05, 14 August 2009MaintBotFixed group labels
29746view22:52, 1 June 2009KhanspersModified categories
27126view08:34, 19 December 2008ThomasModified description
27097view14:21, 18 December 2008ThomasNew pathway

External references


NameTypeDatabase referenceComment
Hand2GeneProduct15111 (Entrez Gene)
Irx5GeneProduct54352 (Entrez Gene)
Kcnd2GeneProduct16508 (Entrez Gene)
mmu-mir-1-1RnaMI0000139 (miRBase Sequence)
mmu-mir-1-2RnaMI0000652 (miRBase Sequence)

Annotated Interactions

No annotated interactions

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