DNA Replication (Drosophila melanogaster)

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1, 2Orc complexOrc3Orc2ADPCdt1GTPCTPwith the replication forkCdc6ATPOrc4Cdc6Cdt1Orc ComplexOrc4DNA polymerase alpha: primase: origin complexCdt1Mcm4Cdt1DNA PolymeraseGemininp180Orc complexRNA primer-DNA primerMcm10Orc35. Leading/lagging strand synthesisCdc6ATPProcessive complexdGTPRFC Heteropentamer:RNA primer-DNA primer:1. Assembly of the pre-replicative complexMcm2RFC40Ubiquitinated Orc1RFC37dATPOrc3Phosphorylated Cdc6Orc2Cdc6Orc3UTPCdt1RNA primer-DNA primer:origin duplex:PCNARFC Heteropentamer:RNA primer-DNA primerMcm6RFC38Orc1RNA primer-DNA primerOrc complexOrc5Phosphorylated Orc1Degraded by proteasome in cytosolMcm5p58Mcm7PCNA homotrimerATPp70Orc5RFC36Origin4. Switching of origins to post-replicative state2. Activation of the pre-replicative complexdCTPDegraded by proteasome in cytosolOrc5ATPMcm6PrimaseMcm3dUTPPre-replicative complexUbiquitinMcm3Mcm7p49RNA PrimerMcm5DNA polymerase alpha: primase: origin complexRFC140Mcm 4,6,7 trimer forms and associatesHOMOLOGY MAPPUbiquitinMcm4Mcm2Orc2ADPUbiquitinated Cdc6aPhosphorylation of Mcm 2-7 complex3. DNA replication initiationOrc complexPre-replicative complexOrc2RfC38Orc6Mcm6RPA3GMNNCG5971CG12018l(1)G0148Orc4Gnf1Mcm2DNAprimOrc1RfC40Orc5RpL40mus209RPA4RpA-70Orc2Pole2latCDK2CG8142DNApol-epsilondpaCDC45LDNApol-alpha180DNApol-alpha73CG9273Ubi-p63EPOLD4Mcm7Mcm5RfC3ASKDNApol-deltaMcm3DNApol-alpha50Mcm10POLD3dup


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
77446view20:30, 8 September 2014MaintBot
71551view19:25, 17 October 2013MaintBotAutomated update of data sources
67164view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62530view13:38, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62523view12:47, 29 April 2013EgonwConnected dots.
40888view22:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35216view15:48, 11 February 2010Thomasadded literature
35212view15:45, 11 February 2010ThomasModified description
35202view15:40, 11 February 2010ThomasModified description
21870view11:32, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:DNA replication Reactome]] moved to [[Pathway:WP565]]: Moved to stable identifier
8513view14:01, 7 January 2008MaintBotAdded to category $category
19416view14:01, 7 January 2008D.KorenUploaded new pathway
8511view14:01, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite
ASKGeneProduct
ATPMetabolite
CDC45LGeneProduct31052 (Entrez Gene)
CDK2GeneProduct
CG12018GeneProduct38228 (Entrez Gene)
CG5971GeneProduct38989 (Entrez Gene)
CG8142GeneProduct32763 (Entrez Gene)
CG9273GeneProduct35364 (Entrez Gene)
CTPMetabolite
DNApol-alpha180GeneProduct42553 (Entrez Gene)
DNApol-alpha50GeneProduct38942 (Entrez Gene)
DNApol-alpha73GeneProduct43278 (Entrez Gene)
DNApol-deltaGeneProduct39746 (Entrez Gene)
DNApol-epsilonGeneProduct42758 (Entrez Gene)
DNAprimGeneProduct44915 (Entrez Gene)
GMNNGeneProduct
GTPMetabolite
Gnf1GeneProduct40607 (Entrez Gene)
Mcm10GeneProduct35390 (Entrez Gene)
Mcm2GeneProduct40973 (Entrez Gene)
Mcm3GeneProduct31449 (Entrez Gene)
Mcm5GeneProduct41296 (Entrez Gene)
Mcm6GeneProduct31603 (Entrez Gene)
Mcm7GeneProduct39014 (Entrez Gene)
Orc1GeneProduct35686 (Entrez Gene)
Orc2GeneProduct41703 (Entrez Gene)
Orc4GeneProduct37970 (Entrez Gene)
Orc5GeneProduct34794 (Entrez Gene)
Orc6GeneProduct36017 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
Pole2GeneProduct38661 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RfC3GeneProduct34423 (Entrez Gene)
RfC38GeneProduct34550 (Entrez Gene)
RfC40GeneProduct38492 (Entrez Gene)
RpA-70GeneProduct40972 (Entrez Gene)
RpL40GeneProduct33629 (Entrez Gene)
UTPMetabolite
Ubi-p63EGeneProduct38456 (Entrez Gene)
UbiquitinMetabolite
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite
dpaGeneProduct35679 (Entrez Gene)
dupGeneProduct47121 (Entrez Gene)
l(1)G0148GeneProduct31598 (Entrez Gene)
latGeneProduct36454 (Entrez Gene)
mus209GeneProduct37290 (Entrez Gene)

Annotated Interactions

No annotated interactions
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