DNA Replication (Drosophila melanogaster)

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1, 2Orc complexRFC Heteropentamer:RNA primer-DNA primerOrc3UbiquitinPhosphorylation of Mcm 2-7 complexUTPGTPOrc2Cdt1ADPOrc2Cdc6GemininCdc6Orc1DNA polymerase alpha: primase: origin complexCdt1Mcm6Mcm10OriginaCdc6RFC36Processive complexp49Cdt1Orc2Orc complexCdt1Orc complexdUTPRNA primer-DNA primer:origin duplex:PCNAMcm2Mcm3RFC140Ubiquitinated Cdc6RFC38UbiquitinOrc5Ubiquitinated Orc1Cdc6Cdt1Orc5ATPMcm2PrimasePCNA homotrimerMcm7RFC40Orc3RNA primer-DNA primerMcm5Orc4Phosphorylated Cdc6RNA primer-DNA primerHOMOLOGY MAPPp704. Switching of origins to post-replicative stateRFC Heteropentamer:RNA primer-DNA primer:dCTPp180Orc4RFC37Orc35. Leading/lagging strand synthesis3. DNA replication initiationdGTPDegraded by proteasome in cytosolOrc2ADPMcm7DNA PolymeraseMcm4dATP2. Activation of the pre-replicative complexATPMcm4Orc ComplexCTPp58Phosphorylated Orc1Mcm5RNA PrimerMcm 4,6,7 trimer forms and associateswith the replication forkATPMcm6Mcm3Orc5ATPDegraded by proteasome in cytosolPre-replicative complexDNA polymerase alpha: primase: origin complexPre-replicative complexOrc complex1. Assembly of the pre-replicative complexOrc3RfC40GMNNMcm5RPA3RPA4dupUbi-p63EPOLD3RpA-70Orc1mus209Mcm7Pole2Orc6Gnf1Orc4Mcm6ASKDNApol-alpha180CDC45LOrc5DNApol-epsilonOrc2DNApol-alpha73CG9273RfC38latMcm3CG12018DNApol-alpha50RfC3DNApol-deltaMcm10dpaCG8142l(1)G0148CG5971Mcm2DNAprimCDK2POLD4RpL40


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
77446view20:30, 8 September 2014MaintBot
71551view19:25, 17 October 2013MaintBotAutomated update of data sources
67164view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62530view13:38, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62523view12:47, 29 April 2013EgonwConnected dots.
40888view22:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35216view15:48, 11 February 2010Thomasadded literature
35212view15:45, 11 February 2010ThomasModified description
35202view15:40, 11 February 2010ThomasModified description
21870view11:32, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:DNA replication Reactome]] moved to [[Pathway:WP565]]: Moved to stable identifier
8513view14:01, 7 January 2008MaintBotAdded to category $category
19416view14:01, 7 January 2008D.KorenUploaded new pathway
8511view14:01, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite
ASKGeneProduct
ATPMetabolite
CDC45LGeneProduct31052 (Entrez Gene)
CDK2GeneProduct
CG12018GeneProduct38228 (Entrez Gene)
CG5971GeneProduct38989 (Entrez Gene)
CG8142GeneProduct32763 (Entrez Gene)
CG9273GeneProduct35364 (Entrez Gene)
CTPMetabolite
DNApol-alpha180GeneProduct42553 (Entrez Gene)
DNApol-alpha50GeneProduct38942 (Entrez Gene)
DNApol-alpha73GeneProduct43278 (Entrez Gene)
DNApol-deltaGeneProduct39746 (Entrez Gene)
DNApol-epsilonGeneProduct42758 (Entrez Gene)
DNAprimGeneProduct44915 (Entrez Gene)
GMNNGeneProduct
GTPMetabolite
Gnf1GeneProduct40607 (Entrez Gene)
Mcm10GeneProduct35390 (Entrez Gene)
Mcm2GeneProduct40973 (Entrez Gene)
Mcm3GeneProduct31449 (Entrez Gene)
Mcm5GeneProduct41296 (Entrez Gene)
Mcm6GeneProduct31603 (Entrez Gene)
Mcm7GeneProduct39014 (Entrez Gene)
Orc1GeneProduct35686 (Entrez Gene)
Orc2GeneProduct41703 (Entrez Gene)
Orc4GeneProduct37970 (Entrez Gene)
Orc5GeneProduct34794 (Entrez Gene)
Orc6GeneProduct36017 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
Pole2GeneProduct38661 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RfC3GeneProduct34423 (Entrez Gene)
RfC38GeneProduct34550 (Entrez Gene)
RfC40GeneProduct38492 (Entrez Gene)
RpA-70GeneProduct40972 (Entrez Gene)
RpL40GeneProduct33629 (Entrez Gene)
UTPMetabolite
Ubi-p63EGeneProduct38456 (Entrez Gene)
UbiquitinMetabolite
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite
dpaGeneProduct35679 (Entrez Gene)
dupGeneProduct47121 (Entrez Gene)
l(1)G0148GeneProduct31598 (Entrez Gene)
latGeneProduct36454 (Entrez Gene)
mus209GeneProduct37290 (Entrez Gene)

Annotated Interactions

No annotated interactions
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