DNA Replication (Drosophila melanogaster)

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1, 2Orc complexATPRFC Heteropentamer:RNA primer-DNA primerADPOrc3Cdt1Cdc6UTPRNA PrimerdUTPOrc2Cdc6DNA polymerase alpha: primase: origin complexUbiquitinated Orc1dGTPMcm6UbiquitinCdt1adATPRFC38Processive complexOrc3p70Orc2ATPOrc5GemininOrc complexPhosphorylated Orc1Orc complexRNA primer-DNA primer:origin duplex:PCNAMcm2Orc5Mcm3UbiquitinRNA primer-DNA primerRFC140CTPRNA primer-DNA primerATPdCTPCdt1Mcm2PrimasePCNA homotrimerOrc5Mcm7Mcm 4,6,7 trimer forms and associatesDNA polymerase alpha: primase: origin complexp58Cdc6Mcm5Phosphorylation of Mcm 2-7 complexDegraded by proteasome in cytosolp49Orc1HOMOLOGY MAPPRFC364. Switching of origins to post-replicative stateRFC Heteropentamer:RNA primer-DNA primer:Orc4RFC37GTPOrc4RFC40Cdt15. Leading/lagging strand synthesis3. DNA replication initiationADPCdt1Mcm7DNA PolymeraseMcm42. Activation of the pre-replicative complexMcm4Orc Complexp180Degraded by proteasome in cytosolOrc3Mcm5Orc2OriginUbiquitinated Cdc6with the replication forkOrc3Orc2Mcm6Mcm3Cdc6ATPPre-replicative complexPhosphorylated Cdc6Pre-replicative complexOrc complex1. Assembly of the pre-replicative complexMcm10RfC40GMNNMcm5RPA3RPA4dupUbi-p63EPOLD3RpA-70Orc1mus209Mcm7Pole2Orc6Gnf1Orc4Mcm6ASKDNApol-alpha180CDC45LOrc5DNApol-epsilonOrc2DNApol-alpha73CG9273RfC38latMcm3CG12018DNApol-alpha50RfC3DNApol-deltaMcm10dpaCG8142l(1)G0148CG5971Mcm2DNAprimCDK2POLD4RpL40


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
77446view20:30, 8 September 2014MaintBot
71551view19:25, 17 October 2013MaintBotAutomated update of data sources
67164view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62530view13:38, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62523view12:47, 29 April 2013EgonwConnected dots.
40888view22:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35216view15:48, 11 February 2010Thomasadded literature
35212view15:45, 11 February 2010ThomasModified description
35202view15:40, 11 February 2010ThomasModified description
21870view11:32, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:DNA replication Reactome]] moved to [[Pathway:WP565]]: Moved to stable identifier
8513view14:01, 7 January 2008MaintBotAdded to category $category
19416view14:01, 7 January 2008D.KorenUploaded new pathway
8511view14:01, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASKGeneProduct
CDC45LGeneProduct31052 (Entrez Gene)
CDK2GeneProduct
CG12018GeneProduct38228 (Entrez Gene)
CG5971GeneProduct38989 (Entrez Gene)
CG8142GeneProduct32763 (Entrez Gene)
CG9273GeneProduct35364 (Entrez Gene)
DNApol-alpha180GeneProduct42553 (Entrez Gene)
DNApol-alpha50GeneProduct38942 (Entrez Gene)
DNApol-alpha73GeneProduct43278 (Entrez Gene)
DNApol-deltaGeneProduct39746 (Entrez Gene)
DNApol-epsilonGeneProduct42758 (Entrez Gene)
DNAprimGeneProduct44915 (Entrez Gene)
GMNNGeneProduct
Gnf1GeneProduct40607 (Entrez Gene)
Mcm10GeneProduct35390 (Entrez Gene)
Mcm2GeneProduct40973 (Entrez Gene)
Mcm3GeneProduct31449 (Entrez Gene)
Mcm5GeneProduct41296 (Entrez Gene)
Mcm6GeneProduct31603 (Entrez Gene)
Mcm7GeneProduct39014 (Entrez Gene)
Orc1GeneProduct35686 (Entrez Gene)
Orc2GeneProduct41703 (Entrez Gene)
Orc4GeneProduct37970 (Entrez Gene)
Orc5GeneProduct34794 (Entrez Gene)
Orc6GeneProduct36017 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
Pole2GeneProduct38661 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RfC3GeneProduct34423 (Entrez Gene)
RfC38GeneProduct34550 (Entrez Gene)
RfC40GeneProduct38492 (Entrez Gene)
RpA-70GeneProduct40972 (Entrez Gene)
RpL40GeneProduct33629 (Entrez Gene)
Ubi-p63EGeneProduct38456 (Entrez Gene)
dpaGeneProduct35679 (Entrez Gene)
dupGeneProduct47121 (Entrez Gene)
l(1)G0148GeneProduct31598 (Entrez Gene)
latGeneProduct36454 (Entrez Gene)
mus209GeneProduct37290 (Entrez Gene)

Annotated Interactions

No annotated interactions
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