DNA Replication (Drosophila melanogaster)

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1, 2DNA polymerase alpha: primase: origin complexOrc1DNA PolymeraseOrc2Orc complexCdt1Orc3UbiquitinaMcm7OriginMcm10Degraded by proteasome in cytosolRFC38CTPRFC140Orc2RNA primer-DNA primerCdc65. Leading/lagging strand synthesis1. Assembly of the pre-replicative complex4. Switching of origins to post-replicative statep70GemininMcm6RFC40Cdc6Orc2ADPMcm2GTPMcm5Mcm3Pre-replicative complexOrc5dATPOrc5RFC Heteropentamer:RNA primer-DNA primer:PrimaseOrc4RNA primer-DNA primerOrc5Mcm 4,6,7 trimer forms and associatesp49Mcm6dUTPPhosphorylated Cdc6Cdt1Pre-replicative complexdCTPPhosphorylated Orc1Mcm5Orc33. DNA replication initiationATPCdt1p58Orc3Orc2PCNA homotrimerOrc4Orc3Cdt1Orc complexProcessive complexATPOrc ComplexOrc complexp180dGTPRNA primer-DNA primer:origin duplex:PCNAATPDegraded by proteasome in cytosolCdc6HOMOLOGY MAPPwith the replication forkRNA PrimerUbiquitinMcm4Mcm7RFC36Cdc6Ubiquitinated Orc1Phosphorylation of Mcm 2-7 complexATPMcm4Orc complexMcm3DNA polymerase alpha: primase: origin complexADPRFC Heteropentamer:RNA primer-DNA primerRFC37Mcm2UTPUbiquitinated Cdc62. Activation of the pre-replicative complexCdt1RPA3Mcm5Orc4CG5971CG9273RfC40Orc5ASKMcm3RpA-70CG12018dpaCDK2l(1)G0148Orc6Mcm10RPA4CG8142Mcm2DNAprimDNApol-deltaMcm6latdupDNApol-alpha180mus209POLD3Ubi-p63EOrc1Mcm7Gnf1GMNNDNApol-epsilonRfC3DNApol-alpha50CDC45LPole2RpL40Orc2DNApol-alpha73POLD4RfC38


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
77446view20:30, 8 September 2014MaintBot
71551view19:25, 17 October 2013MaintBotAutomated update of data sources
67164view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62530view13:38, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62523view12:47, 29 April 2013EgonwConnected dots.
40888view22:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35216view15:48, 11 February 2010Thomasadded literature
35212view15:45, 11 February 2010ThomasModified description
35202view15:40, 11 February 2010ThomasModified description
21870view11:32, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:DNA replication Reactome]] moved to [[Pathway:WP565]]: Moved to stable identifier
8513view14:01, 7 January 2008MaintBotAdded to category $category
19416view14:01, 7 January 2008D.KorenUploaded new pathway
8511view14:01, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASKGeneProduct
CDC45LGeneProduct31052 (Entrez Gene)
CDK2GeneProduct
CG12018GeneProduct38228 (Entrez Gene)
CG5971GeneProduct38989 (Entrez Gene)
CG8142GeneProduct32763 (Entrez Gene)
CG9273GeneProduct35364 (Entrez Gene)
DNApol-alpha180GeneProduct42553 (Entrez Gene)
DNApol-alpha50GeneProduct38942 (Entrez Gene)
DNApol-alpha73GeneProduct43278 (Entrez Gene)
DNApol-deltaGeneProduct39746 (Entrez Gene)
DNApol-epsilonGeneProduct42758 (Entrez Gene)
DNAprimGeneProduct44915 (Entrez Gene)
GMNNGeneProduct
Gnf1GeneProduct40607 (Entrez Gene)
Mcm10GeneProduct35390 (Entrez Gene)
Mcm2GeneProduct40973 (Entrez Gene)
Mcm3GeneProduct31449 (Entrez Gene)
Mcm5GeneProduct41296 (Entrez Gene)
Mcm6GeneProduct31603 (Entrez Gene)
Mcm7GeneProduct39014 (Entrez Gene)
Orc1GeneProduct35686 (Entrez Gene)
Orc2GeneProduct41703 (Entrez Gene)
Orc4GeneProduct37970 (Entrez Gene)
Orc5GeneProduct34794 (Entrez Gene)
Orc6GeneProduct36017 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
Pole2GeneProduct38661 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RfC3GeneProduct34423 (Entrez Gene)
RfC38GeneProduct34550 (Entrez Gene)
RfC40GeneProduct38492 (Entrez Gene)
RpA-70GeneProduct40972 (Entrez Gene)
RpL40GeneProduct33629 (Entrez Gene)
Ubi-p63EGeneProduct38456 (Entrez Gene)
dpaGeneProduct35679 (Entrez Gene)
dupGeneProduct47121 (Entrez Gene)
l(1)G0148GeneProduct31598 (Entrez Gene)
latGeneProduct36454 (Entrez Gene)
mus209GeneProduct37290 (Entrez Gene)

Annotated Interactions

No annotated interactions
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