DNA Replication (Drosophila melanogaster)

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Primasep180RFC40UbiquitinRNA primer-DNA primerMcm6Degraded by proteasome in cytosolCdc6Mcm10Degraded by proteasome in cytosolATPMcm4Mcm5Cdc6DNA PolymeraseADPMcm7Orc3dATPOrc complexOrc2Ubiquitinated Cdc6HOMOLOGY MAPPATPOrc5CTPRNA primer-DNA primerOrc5ATPOrc ComplexaOrc2RFC37Mcm3p58GemininRFC38Mcm6Cdt1Cdt1ATPOrc complexdUTPOrc5ADPMcm2Cdc6with the replication forkPre-replicative complexMcm42. Activation of the pre-replicative complexPCNA homotrimerProcessive complexRFC36Orc3p70p49Orc3Orc4RFC Heteropentamer:RNA primer-DNA primerGTPOrc4UTPPhosphorylated Cdc6Orc complex1. Assembly of the pre-replicative complexMcm7Mcm3DNA polymerase alpha: primase: origin complexRFC140RNA PrimerPhosphorylated Orc13. DNA replication initiationCdt1Orc complexOrc3Mcm 4,6,7 trimer forms and associatesCdt1Cdt1Phosphorylation of Mcm 2-7 complexRFC Heteropentamer:RNA primer-DNA primer:4. Switching of origins to post-replicative stateOrc1dCTPRNA primer-DNA primer:origin duplex:PCNA5. Leading/lagging strand synthesisMcm5Ubiquitinated Orc1Orc2UbiquitinPre-replicative complexMcm2Orc2DNA polymerase alpha: primase: origin complexdGTPOriginCdc6DNApol-alpha180Gnf1ASKPOLD4CG8142Ubi-p63EdupCG9273RfC3Pole2Orc4RfC40DNApol-alpha73latRfC38CDK2CG5971Orc5Orc1Mcm3CDC45Lmus209DNApol-alpha50RPA4Orc2Mcm7Orc6RpL40POLD3DNApol-epsilonGMNNMcm2Mcm6DNAprimRPA3RpA-70DNApol-deltaMcm5dpaMcm10CG12018l(1)G0148


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
77446view20:30, 8 September 2014MaintBot
71551view19:25, 17 October 2013MaintBotAutomated update of data sources
67164view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62530view13:38, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62523view12:47, 29 April 2013EgonwConnected dots.
40888view22:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35216view15:48, 11 February 2010Thomasadded literature
35212view15:45, 11 February 2010ThomasModified description
35202view15:40, 11 February 2010ThomasModified description
21870view11:32, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:DNA replication Reactome]] moved to [[Pathway:WP565]]: Moved to stable identifier
8513view14:01, 7 January 2008MaintBotAdded to category $category
19416view14:01, 7 January 2008D.KorenUploaded new pathway
8511view14:01, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASKGeneProduct
CDC45LGeneProduct31052 (Entrez Gene)
CDK2GeneProduct
CG12018GeneProduct38228 (Entrez Gene)
CG5971GeneProduct38989 (Entrez Gene)
CG8142GeneProduct32763 (Entrez Gene)
CG9273GeneProduct35364 (Entrez Gene)
DNApol-alpha180GeneProduct42553 (Entrez Gene)
DNApol-alpha50GeneProduct38942 (Entrez Gene)
DNApol-alpha73GeneProduct43278 (Entrez Gene)
DNApol-deltaGeneProduct39746 (Entrez Gene)
DNApol-epsilonGeneProduct42758 (Entrez Gene)
DNAprimGeneProduct44915 (Entrez Gene)
GMNNGeneProduct
Gnf1GeneProduct40607 (Entrez Gene)
Mcm10GeneProduct35390 (Entrez Gene)
Mcm2GeneProduct40973 (Entrez Gene)
Mcm3GeneProduct31449 (Entrez Gene)
Mcm5GeneProduct41296 (Entrez Gene)
Mcm6GeneProduct31603 (Entrez Gene)
Mcm7GeneProduct39014 (Entrez Gene)
Orc1GeneProduct35686 (Entrez Gene)
Orc2GeneProduct41703 (Entrez Gene)
Orc4GeneProduct37970 (Entrez Gene)
Orc5GeneProduct34794 (Entrez Gene)
Orc6GeneProduct36017 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
Pole2GeneProduct38661 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RfC3GeneProduct34423 (Entrez Gene)
RfC38GeneProduct34550 (Entrez Gene)
RfC40GeneProduct38492 (Entrez Gene)
RpA-70GeneProduct40972 (Entrez Gene)
RpL40GeneProduct33629 (Entrez Gene)
Ubi-p63EGeneProduct38456 (Entrez Gene)
dpaGeneProduct35679 (Entrez Gene)
dupGeneProduct47121 (Entrez Gene)
l(1)G0148GeneProduct31598 (Entrez Gene)
latGeneProduct36454 (Entrez Gene)
mus209GeneProduct37290 (Entrez Gene)

Annotated Interactions

No annotated interactions
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