DNA Replication (Drosophila melanogaster)

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DNA PolymeraseRFC36RFC140with the replication forkRNA primer-DNA primerMcm7Degraded by proteasome in cytosolCdt1Cdt1RNA primer-DNA primerPCNA homotrimerMcm6HOMOLOGY MAPPCdt1aOriginp494. Switching of origins to post-replicative stateRFC Heteropentamer:RNA primer-DNA primerPhosphorylated Orc1Orc complexOrc3Degraded by proteasome in cytosolADPOrc2GTPATPOrc4RNA PrimerCdc6Pre-replicative complexOrc5RFC38Mcm4p70Cdc6RFC40Mcm7Mcm10GemininADPProcessive complexdATPOrc4Phosphorylated Cdc6Mcm3Cdt1Orc21. Assembly of the pre-replicative complexMcm63. DNA replication initiationRFC Heteropentamer:RNA primer-DNA primer:Orc complexRFC37Orc2p180p58Orc5Orc1ATPUTPOrc2ATPUbiquitinated Orc1Orc complexMcm2Orc ComplexMcm4DNA polymerase alpha: primase: origin complexMcm 4,6,7 trimer forms and associatesdCTPUbiquitinPre-replicative complexPhosphorylation of Mcm 2-7 complexMcm5Orc5UbiquitinCdt1Mcm2DNA polymerase alpha: primase: origin complexRNA primer-DNA primer:origin duplex:PCNA5. Leading/lagging strand synthesisOrc3dGTPPrimaseOrc complexMcm5Ubiquitinated Cdc6Cdc6ATP2. Activation of the pre-replicative complexMcm3Orc3CTPdUTPOrc3Cdc6DNApol-alpha50mus209l(1)G0148DNApol-deltaRfC38RpL40CG8142DNApol-epsilonOrc1Gnf1RfC3Orc2RfC40DNApol-alpha73Ubi-p63EOrc4Orc6Mcm2CG12018ASKDNAprimDNApol-alpha180Orc5Mcm10GMNNMcm6RPA3POLD4latCG9273dupMcm7Mcm5Pole2RPA4CDC45LCG5971dpaMcm3CDK2POLD3RpA-70


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: [wikipedia:DNA_replication|Wikipedia]

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
77446view20:30, 8 September 2014MaintBot
71551view19:25, 17 October 2013MaintBotAutomated update of data sources
67164view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62530view13:38, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62523view12:47, 29 April 2013EgonwConnected dots.
40888view22:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35216view15:48, 11 February 2010Thomasadded literature
35212view15:45, 11 February 2010ThomasModified description
35202view15:40, 11 February 2010ThomasModified description
21870view11:32, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:DNA replication Reactome]] moved to [[Pathway:WP565]]: Moved to stable identifier
8513view14:01, 7 January 2008MaintBotAdded to category $category
19416view14:01, 7 January 2008D.KorenUploaded new pathway
8511view14:01, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASKGeneProduct
CDC45LGeneProduct31052 (Entrez Gene)
CDK2GeneProduct
CG12018GeneProduct38228 (Entrez Gene)
CG5971GeneProduct38989 (Entrez Gene)
CG8142GeneProduct32763 (Entrez Gene)
CG9273GeneProduct35364 (Entrez Gene)
DNApol-alpha180GeneProduct42553 (Entrez Gene)
DNApol-alpha50GeneProduct38942 (Entrez Gene)
DNApol-alpha73GeneProduct43278 (Entrez Gene)
DNApol-deltaGeneProduct39746 (Entrez Gene)
DNApol-epsilonGeneProduct42758 (Entrez Gene)
DNAprimGeneProduct44915 (Entrez Gene)
GMNNGeneProduct
Gnf1GeneProduct40607 (Entrez Gene)
Mcm10GeneProduct35390 (Entrez Gene)
Mcm2GeneProduct40973 (Entrez Gene)
Mcm3GeneProduct31449 (Entrez Gene)
Mcm5GeneProduct41296 (Entrez Gene)
Mcm6GeneProduct31603 (Entrez Gene)
Mcm7GeneProduct39014 (Entrez Gene)
Orc1GeneProduct35686 (Entrez Gene)
Orc2GeneProduct41703 (Entrez Gene)
Orc4GeneProduct37970 (Entrez Gene)
Orc5GeneProduct34794 (Entrez Gene)
Orc6GeneProduct36017 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
Pole2GeneProduct38661 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RfC3GeneProduct34423 (Entrez Gene)
RfC38GeneProduct34550 (Entrez Gene)
RfC40GeneProduct38492 (Entrez Gene)
RpA-70GeneProduct40972 (Entrez Gene)
RpL40GeneProduct33629 (Entrez Gene)
Ubi-p63EGeneProduct38456 (Entrez Gene)
dpaGeneProduct35679 (Entrez Gene)
dupGeneProduct47121 (Entrez Gene)
l(1)G0148GeneProduct31598 (Entrez Gene)
latGeneProduct36454 (Entrez Gene)
mus209GeneProduct37290 (Entrez Gene)

Annotated Interactions

No annotated interactions
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