ID signaling pathway (Homo sapiens)

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Regulation of gene expressionLigandsmRNAReceptorProteinReceptorEnzyme complexLigandID Signaling PathwayELK4 SREBF1ELK1 CCNE1PAX2 RBL1MYOD1PAX8 CDK2ID3PAX5 RBL2ELK3RB1PID2PInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageID1ID1/ ID2/ ID3 protein expressionProtein


The Inhibitor of DNA binding (ID) proteins belong to the class V HLH family of transcription factors. Four ID proteins (ID 1-4)are known in humans. Unlike the basic HLH (bHLH) transcription factors, ID proteins lack the basic DNA binding region. They can heterodimerize with class I bHLH transcription factors to form inactive complexes. They thus act as dominant negative inhibitors of the class I bHLH transcription factors. They are also capable of regulating the activity of class II HLH transcription factors. Since, class I and II HLH proteins regulate the expression of cell type-specific genes and differentiated phenotype, ID proteins are thought to regulate the cross-talk between the pathways involved in cell growth and differentiation. Aberrant expression of ID proteins are found in many primary tumors and are found to regulate many steps in cancer progression including neo-angiogenesis, invasion and migration, proliferation and growth, cell-cell interaction and differentiation. These include head and neck squamous cell carcinoma, esophageal squamous cell carcinoma, melanoma, hepatocellular carcinonoma, pancreatic cancer, ovarian cancer, cervical cancer, breast cancer and prostate cancer. Among the transcription factors that ID proteins associate with are the Ets family members (ELKs) and paired box family (PAXs). They can also bind to the retinoblastoma and retinoblastoma-like proteins (RBLs), which are thought to be tumor suppressors. IDs can also be phosphorylated by CDK2.

Please access this pathway at NetSlim database.

If you use this pathway, you must cite following paper:

Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V., Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Rahiman, B. A., Prasad, T. S. K., Lin, J., Houtman, J. C. D., Desiderio, S., Renauld, J., Constantinescu, S. N., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. Genome Biology. 11:R3.

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108330view21:15, 6 December 2019L DupuisConverted interactions to graphical lines in legend
67360view10:42, 26 June 2013Christine ChichesterOntology Term : 'Inhibitor of DNA binding signaling pathway' added !
63207view20:57, 8 May 2013MaintBotUpdating gpml version
47974view14:26, 23 April 2012NetPathModified description
44841view09:43, 6 October 2011MartijnVanIerselOntology Term : 'signaling pathway' added !
44834view08:01, 6 October 2011Mkutmonconnected some lines
44602view21:13, 21 September 2011KhanspersModified description
44601view21:12, 21 September 2011KhanspersUpdating content to NetSlim
44116view20:44, 24 August 2011KhanspersReverted to version '23:44, 1 March 2011' by Khanspers
44042view23:30, 22 August 2011KhanspersModified description
44040view23:28, 22 August 2011KhanspersUpdating pathway from NetSlim
41212view23:44, 1 March 2011MaintBotRemoved redundant pathway information and comments
35648view21:39, 12 February 2010KhanspersModified description
34465view18:29, 10 December 2009MaintBotAutomatic update of empty xrefs
20789view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Id NetPath 5]] moved to [[Pathway:WP53]]: Moved to stable identifier
8152view13:46, 7 January 2008MaintBot[[Pathway:Human:Id NetPath 5]] moved to [[Pathway:Homo sapiens:Id NetPath 5]]: Renaming species
7696view16:10, 18 December 2007MaintBotfixed category names
7262view12:41, 4 November 2007MaintBotAdded categories to GPML
6342view22:18, 22 May 2007A.Pandeygpml file for [[Human:Id_NetPath_5]]

External references


View all...
NameTypeDatabase referenceComment
CCNE1Protein898 (Entrez Gene)
CDK2Protein1017 (Entrez Gene)
ELK1 Protein2002 (Entrez Gene)
ELK3Protein2004 (Entrez Gene)
ELK4 Protein2005 (Entrez Gene)
ID1Protein3397 (Entrez Gene)
ID2Protein3398 (Entrez Gene)
ID3Protein3399 (Entrez Gene)
MYOD1Protein4654 (Entrez Gene)
PAX2 Protein5076 (Entrez Gene)
PAX5 Protein5079 (Entrez Gene)
PAX8 Protein7849 (Entrez Gene)
RB1Protein5925 (Entrez Gene)
RBL1Protein5933 (Entrez Gene)
RBL2Protein5934 (Entrez Gene)
SREBF1Protein6720 (Entrez Gene)

Annotated Interactions

No annotated interactions

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