Mitochondrial Unfolded-Protein Response (UPRmt) (Caenorhabditis elegans)

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1NucleusStress signalProteinConformational StressMitochondrionhsp-60hsp-6ubl-5hsp-6ubl-5ubl-5dve-1dve-1hsp-60clpp-1ubl-5


hypothetical pathway based on a single review article. Input on alternatives is welcome

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  1. Haynes CM, Yang Y, Blais SP, Neubert TA, Ron D; ''The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans.''; Mol Cell, 2010 PubMed Europe PMC Scholia
  2. Baker BM, Nargund AM, Sun T, Haynes CM; ''Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2.''; PLoS Genet, 2012 PubMed Europe PMC Scholia
  3. Haynes CM, Ron D; ''The mitochondrial UPR - protecting organelle protein homeostasis.''; J Cell Sci, 2010 PubMed Europe PMC Scholia
  4. Benedetti C, Haynes CM, Yang Y, Harding HP, Ron D; ''Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response.''; Genetics, 2006 PubMed Europe PMC Scholia
  5. Haynes CM, Petrova K, Benedetti C, Yang Y, Ron D; ''ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans.''; Dev Cell, 2007 PubMed Europe PMC Scholia
  6. Nargund AM, Pellegrino MW, Fiorese CJ, Baker BM, Haynes CM; ''Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.''; Science, 2012 PubMed Europe PMC Scholia
  7. Pellegrino MW, Nargund AM, Haynes CM; ''Signaling the mitochondrial unfolded protein response.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
  8. Yoneda T, Benedetti C, Urano F, Clark SG, Harding HP, Ron D; ''Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones.''; J Cell Sci, 2004 PubMed Europe PMC Scholia
  9. Broadley SA, Hartl FU; ''Mitochondrial stress signaling: a pathway unfolds.''; Trends Cell Biol, 2008 PubMed Europe PMC Scholia


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107348view19:41, 26 September 2019Khansperstest
84475view19:37, 25 February 2016AlexanderPicoQuick edit to datanode annotation or property
78459view10:27, 7 January 2015MaintBotadded missing graphIds
74871view17:35, 5 May 2014CgroveChanged ATFS-1 to activating dnj-10 expression instead of inhibiting
74855view23:28, 1 May 2014CgroveCleaning up
74097view14:19, 29 March 2014EgonwReplaced an outdated HMDB identifier with the ChEBI one.
73816view01:17, 25 February 2014CgroveAdded CheBI identifier to ethidium bromide
73815view01:15, 25 February 2014CgroveConnected lines to Unfolded proteins and Protein Fragments data nodes instead of graphical cartoons
73814view01:14, 25 February 2014CgrovePeriodical save, work in progress
73487view22:59, 29 January 2014CgroveAdded "Gene Transcription" to legend
73486view22:42, 29 January 2014CgroveCleaning up legend
73485view22:39, 29 January 2014CgroveAdding legend text
73484view22:39, 29 January 2014CgrovePeriodical save, work in progress
73483view22:37, 29 January 2014CgroveEditing legend
73482view22:36, 29 January 2014CgroveAdding legend
73481view22:36, 29 January 2014CgroveCleaning up
73480view22:35, 29 January 2014CgroveCleaning up
73479view22:33, 29 January 2014CgroveCleaning up
73478view22:32, 29 January 2014CgroveCleaning up
73477view22:32, 29 January 2014CgroveCleaning up
73476view22:29, 29 January 2014CgroveCleaning up
73465view22:23, 29 January 2014CgroveCleaning up
73460view22:21, 29 January 2014CgroveCleaning up
73456view22:19, 29 January 2014CgroveTesting Save
73376view20:23, 24 January 2014CgroveCleaning up
73375view20:20, 24 January 2014CgroveCleaning up
73374view20:11, 24 January 2014CgroveCleaning up
73373view20:07, 24 January 2014CgroveCleaning up
73372view20:03, 24 January 2014CgrovePeriodical save, work in progress
73371view20:03, 24 January 2014CgroveMajor Cleaning Up
73370view19:53, 24 January 2014CgrovePeriodical save, work in progress
73369view19:43, 24 January 2014CgrovePeriodical save, work in progress
73368view19:33, 24 January 2014CgrovePeriodical save, work in progress
73147view21:18, 7 January 2014KyookOntology Term : 'PW:0000379' removed !
73146view21:18, 7 January 2014KyookOntology Term : 'stress response pathway' added !
73097view00:19, 3 January 2014KyookModified description
73096view00:19, 3 January 2014KyookModified title
73090view22:55, 2 January 2014CgroveModified description
73086view21:15, 2 January 2014Cgrovecleaning up
73040view00:55, 21 December 2013CgrovePeriodical save, work in progress
73039view00:45, 21 December 2013CgrovePeriodical save, work in progress
73038view00:33, 21 December 2013CgroveAdded references
73037view00:31, 21 December 2013CgroveCleaning up
73036view00:25, 21 December 2013CgrovePeriodical save, work in progress
73035view00:21, 21 December 2013CgroveAdded mitochondrial membrane protein transporters TIOMM-40 and TIMM-23 and reference
73034view00:15, 21 December 2013CgrovePeriodical save, work in progress
73033view00:10, 21 December 2013CgroveCleaning up
73032view00:03, 21 December 2013CgroveAdded reference for GSP-1 dephosphorylation of eIF2-alpha
73031view23:59, 20 December 2013CgrovePeriodical save, work in progress
73030view23:55, 20 December 2013CgroveCleaning up

External references


NameTypeDatabase referenceComment
clpp-1UnknownZK970.2 (WormBase)
dve-1UnknownZK1193.5 (WormBase)
hsp-60UnknownY22D7AL.5 (WormBase)
hsp-6UnknownC37H5.8 (WormBase)
ubl-5UnknownF46F11.4 (WormBase)

Annotated Interactions

No annotated interactions

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