Proteasome Degradation (Mus musculus)

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Alpha subunitsOxidatively DamagedCytosolic ProteinsLid subunitsp45 ATPase SubunitProteasome 26 S(PA700) (ATP dependent)Presentation by MHC class 1Proteasome 20SCatalytic Core (p45)Proteins to be DegradedBeta subunitsUbiquitin/E2 ComplexDegrades only PeptidesActivators of20S ComplexDeubiquitinates proteinsUnfolds and DegradesIntact ProteinsAMP Ubiquitin/E1 ComplexUbiquitin/ProteinE3/ProteinH2-Q10Psmb10Psmd6Psmd10Psmb7HLA-JPsmb3H2afzUbe1lPsmb6Psma6HLA-BPsme1Psmd13Psmc2Psmd12Psma4Psma1Psmc1Psmb5Psmd1UbbHLA-CH2afxPsme3Psmd5IfngPsmd7Uba1Psmb4Psmc5Psma2UbcUchl3Psmd11Rpn2HLA-HH2-M5Psma7Psmb8Psmb9Psme2Psmc5Nedd4Psmc6Psmb1Rpn1Hist1h2abdATPUbe2d2Psmd8Psmd2Psmc3H2-M3Ube2bPsmd9Uchl1Ube2d1Psma5Psmd3Psmb2Psma3Psmc4HLA-EUbiquitinGm4596Psmd4


No description


This pathway was inferred from Homo sapiens pathway WP183(r29614) with a 83% conversion rate.

Quality Tags

Ontology Terms



  1. Hershko A, Ciechanover A, Varshavsky A; ''Basic Medical Research Award. The ubiquitin system.''; Nat Med, 2000 PubMed Europe PMC Scholia
  2. Lasker K, Förster F, Bohn S, Walzthoeni T, Villa E, Unverdorben P, Beck F, Aebersold R, Sali A, Baumeister W; ''Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach.''; Proc Natl Acad Sci U S A, 2012 PubMed Europe PMC Scholia


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95796view14:41, 19 January 2018MkutmonHomology conversion update
71732view20:17, 17 October 2013MaintBotAutomated update of data sources
71320view17:16, 17 October 2013MaintBotAutomated update of data sources
69110view18:13, 8 July 2013MaintBotUpdated to 2013 gpml schema
67615view11:33, 26 June 2013DdiglesOntology Term : 'ubiquitin/proteasome degradation pathway' added !
62832view04:45, 3 May 2013MaintBotUpdated UniProt data source
59032view20:41, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41297view00:23, 2 March 2011MaintBotRemoved redundant pathway information and comments
33047view21:58, 7 October 2009MaintBotAdded xrefs
32452view17:23, 15 August 2009MaintBotFixed text labels
32133view13:56, 14 August 2009MaintBotFixed group labels
31470view21:19, 13 August 2009MaintBotFixed text labels
30910view00:27, 30 July 2009MaintBotConverted from Homo sapiens
21770view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Proteasome Degradation]] moved to [[Pathway:WP519]]: Moved to stable identifier
8350view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Proteasome Degradation]] moved to [[Pathway:Mus musculus:Proteasome Degradation]]: Renaming species
7793view16:18, 18 December 2007MaintBotfixed category names
7486view12:42, 4 November 2007MaintBotAdded categories to GPML
6488view22:19, 22 May 2007Nsalomonisgpml file for [[Mouse:Proteasome_Degradation]]

External references


View all...
NameTypeDatabase referenceComment
Gm4596GeneProduct100043702 (Entrez Gene)
H2-M3GeneProduct14991 (Entrez Gene)
H2-M5GeneProduct240095 (Entrez Gene)
H2-Q10GeneProduct15007 (Entrez Gene)
H2afxGeneProduct15270 (Entrez Gene)
H2afzGeneProduct51788 (Entrez Gene)
Hist1h2abGeneProduct319172 (Entrez Gene)
IfngGeneProduct15978 (Entrez Gene)
Nedd4GeneProduct17999 (Entrez Gene)
Psma1GeneProduct26440 (Entrez Gene)
Psma2GeneProduct19166 (Entrez Gene)
Psma3GeneProduct19167 (Entrez Gene)
Psma4GeneProduct26441 (Entrez Gene)
Psma5GeneProduct26442 (Entrez Gene)
Psma6GeneProduct26443 (Entrez Gene)
Psma7GeneProduct26444 (Entrez Gene)
Psmb10GeneProduct19171 (Entrez Gene)
Psmb1GeneProduct19170 (Entrez Gene)
Psmb2GeneProduct26445 (Entrez Gene)
Psmb3GeneProduct26446 (Entrez Gene)
Psmb4GeneProduct19172 (Entrez Gene)
Psmb5GeneProduct19173 (Entrez Gene)
Psmb6GeneProduct19175 (Entrez Gene) U13393
Psmb7GeneProduct19177 (Entrez Gene)
Psmb8GeneProduct16913 (Entrez Gene)
Psmb9GeneProduct16912 (Entrez Gene)
Psmc1GeneProduct19179 (Entrez Gene)
Psmc2GeneProduct19181 (Entrez Gene)
Psmc3GeneProduct19182 (Entrez Gene)
Psmc4GeneProduct23996 (Entrez Gene) PRS6 HUMAN
Psmc5GeneProduct19184 (Entrez Gene) PRS6 HUMAN
Psmc6GeneProduct67089 (Entrez Gene)
Psmd10GeneProduct53380 (Entrez Gene)
Psmd11GeneProduct69077 (Entrez Gene)
Psmd12GeneProduct66997 (Entrez Gene)
Psmd13GeneProduct23997 (Entrez Gene)
Psmd1GeneProduct70247 (Entrez Gene)
Psmd2GeneProduct21762 (Entrez Gene)
Psmd3GeneProduct22123 (Entrez Gene)
Psmd4GeneProduct19185 (Entrez Gene)
Psmd5GeneProduct66998 (Entrez Gene)
Psmd6GeneProduct66413 (Entrez Gene)
Psmd7GeneProduct17463 (Entrez Gene)
Psmd8GeneProduct57296 (Entrez Gene)
Psmd9GeneProduct67151 (Entrez Gene)
Psme1GeneProduct19186 (Entrez Gene)
Psme2GeneProduct19188 (Entrez Gene)
Psme3GeneProduct19192 (Entrez Gene)
Rpn1GeneProduct103963 (Entrez Gene)
Rpn2GeneProduct20014 (Entrez Gene)
Uba1GeneProduct22201 (Entrez Gene)
UbbGeneProductMGI:98888 (MGI)
UbcGeneProduct22190 (Entrez Gene)
Ube1lGeneProduct74153 (Entrez Gene)
Ube2bGeneProduct22210 (Entrez Gene)
Ube2d1GeneProduct216080 (Entrez Gene)
Ube2d2GeneProduct56550 (Entrez Gene)
Uchl1GeneProductENSMUSG00000029223 (Ensembl Mouse)
Uchl3GeneProduct50933 (Entrez Gene)
dATPMetaboliteHMDB01532 (HMDB)

Annotated Interactions

No annotated interactions
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