Non-classical role of vitamin D (Homo sapiens)

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1SBlood streamKidneySARS Cov-2 with genomeStrongImmunityUV (295-320 nm)SkinDiabetesIncrease in Na, K retention, Increase vasoconstrictionLiverHTN & CVDSARS glycoprotein spike& anti-proliferationACE25-hydroxylaseApoptosis25-hydroxycholecalciferolVasodilationROS productioncytokines and inflammationInflammationFibrosisType-1 angiotensin II receptorangiotensin ICholecalciferol1,25-dihydroxycholecalciferolType-2 angiotensin II receptorAngiotensin II1-alpha-hydroxylase AngiotensinogenRenal Type-1 angiotensin II receptorReninaldosteronevitamin D receptor agonistsACE21,25-dihydroxycholecalciferol7-DehydrocholesterolS


Non classical role of vitamin D3

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  1. Malek Mahdavi A; ''A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19.''; Rev Med Virol, 2020 PubMed Europe PMC Scholia
  2. Berridge MJ; ''Vitamin D deficiency and diabetes.''; Biochem J, 2017 PubMed Europe PMC Scholia
  3. McLachlan CS; ''The angiotensin-converting enzyme 2 (ACE2) receptor in the prevention and treatment of COVID-19 are distinctly different paradigms.''; Clin Hypertens, 2020 PubMed Europe PMC Scholia
  4. Pérez-Hernández N, Aptilon-Duque G, Nostroza-Hernández MC, Vargas-Alarcón G, Rodríguez-Pérez JM, Blachman-Braun R; ''Vitamin D and its effects on cardiovascular diseases: a comprehensive review.''; Korean J Intern Med, 2016 PubMed Europe PMC Scholia


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124643view12:59, 18 November 2022NhungPAdjust layout to improve readability
121511view03:29, 20 February 2022EweitzModified title
120956view10:17, 3 February 2022EgonwModified description
120955view10:14, 3 February 2022EgonwMade six pathways clickable
120233view11:29, 17 November 2021EweitzModified title
120115view14:02, 4 November 2021HumeraFiazChanges in references
120114view14:00, 4 November 2021HumeraFiazChanges in bibliography
120113view13:54, 4 November 2021HumeraFiazUpdated some graphical elements and added bibliography.
120105view15:11, 3 November 2021HumeraFiazModified description
120104view15:07, 3 November 2021HumeraFiazOntology Term : 'diabetes mellitus' added !
120103view14:51, 3 November 2021HumeraFiazModified description
120095view12:12, 2 November 2021SusanOntology Term : 'hypertension' added !
119959view10:56, 30 September 2021SusanOntology Term : 'COVID-19' added !
119958view10:55, 30 September 2021SusanOntology Term : 'vitamin D signaling pathway' added !
119957view10:55, 30 September 2021SusanOntology Term : 'vitamin D metabolic pathway' added !
119949view17:31, 28 September 2021HumeraFiazNew pathway

External references


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NameTypeDatabase referenceComment
1,25-dihydroxycholecalciferolMetaboliteCHEBI:17823 (ChEBI)
1-alpha- hydroxylase ProteinV9GYP0 (Uniprot-TrEMBL)
25-hydroxycholecalciferolMetaboliteCHEBI:17933 (ChEBI)
25-hydroxylaseProteinE9PS56 (Uniprot-TrEMBL)
7-DehydrocholesterolMetaboliteCHEBI:17759 (ChEBI)
ACE2ProteinQ9BYF1 (Uniprot-TrEMBL)
ACEProteinA0A0A0MSN4 (Uniprot-TrEMBL)
Angiotensin IIMetaboliteHMDB01035 (HMDB)
AngiotensinogenProteinP01019 (Uniprot-TrEMBL)
ApoptosisPathwayWP254 (WikiPathways)
CholecalciferolMetaboliteCHEBI:28940 (ChEBI)
FibrosisPathwayWP3624 (WikiPathways)
InflammationPathwayWP4479 (WikiPathways)
ROS productionPathwayWP4969 (WikiPathways)
Renal Type-1

angiotensin II

ProteinP30556 (Uniprot-TrEMBL)
ReninProteinP00797 (Uniprot-TrEMBL)

angiotensin II

ProteinP30556 (Uniprot-TrEMBL)

angiotensin II

ProteinP50052 (Uniprot-TrEMBL)
VasodilationPathwayWP4580 (WikiPathways)
aldosteroneMetaboliteQ184564 (Wikidata)
angiotensin IMetaboliteCHEBI:2718 (ChEBI)
cytokines and inflammationPathwayWP530 (WikiPathways)
vitamin D receptor agonistsMetaboliteCHEBI:139503 (ChEBI)

Annotated Interactions

No annotated interactions

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