FAS pathway and stress induction of HSP regulation (Danio rerio)

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1DNA presentationStress Induction of HSP regulationStressCytoplasmCutProteasomeNucleusFAS PathwayNecrosisROSActivateInhibitionMitochondria Pathway3x-PCell SurvivalExtracellularSelf-activationApoptosome3x-P3x-PNFK-B Pathwayhspb1casp8Phosphatehspb1fasPhosphatelmnapak2aPhosphatecasp8l2mapk8aTNFwu:fa96e12spna2map2k4adffbPhosphatedffaBCL2IL1Almnb2hspb1pak1FAP1rb1parp1mapkapk3faf1daxxfaslghspb1actinPhosphatedffbarhgdigjunfaf1CASP3map3k7CASP3mapkapk2aapaf1cycsbcasp8GlutathioneApoptosisLOC100334486Ceramidefaddripk2casp6lmnb1cflarhspb1hspb1casp9Phosphatehspb1Phosphateapaf1Phosphatecasp7daxxhspb1


This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: BioCarta.


GenMAPP remarks 
Converted to human by GenMAPP.org.
This pathway was inferred from Homo sapiens pathway WP314(r45253) with a 86% conversion rate.

Quality Tags

Ontology Terms



  1. Creagh EM, Sheehan D, Cotter TG; ''Heat shock proteins--modulators of apoptosis in tumour cells.''; Leukemia, 2000 PubMed Europe PMC Scholia


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116873view10:56, 15 May 2021EweitzModified title
113953view06:20, 11 December 2020EgonwAnother clickable pathway
109415view19:00, 16 March 2020L DupuisFixed interactions
106088view11:59, 16 August 2019MaintBotHMDB identifier normalization
68680view05:39, 6 July 2013MaintBotUpdated to 2013 gpml schema
67222view10:23, 26 June 2013Christine ChichesterOntology Term : 'FasL mediated signaling pathway' added !
47922view22:18, 18 April 2012KhanspersUpdating from human to fix xref duplication
40853view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
38239view21:17, 27 August 2010KhanspersRemoved receptor and protein complex graphics
35563view15:03, 12 February 2010Thomasadded literature
35561view15:02, 12 February 2010ThomasModified description
34235view21:39, 9 December 2009MaintBotAutomatic update of empty xrefs
32450view17:22, 15 August 2009MaintBotFixed text labels
32130view13:55, 14 August 2009MaintBotFixed group labels
31467view21:18, 13 August 2009MaintBotFixed text labels
31062view01:26, 30 July 2009MaintBotConverted from Homo sapiens
21754view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:Fas Pathway and Stress Induction of HSP Regulation Biocarta]] moved to [[Pathway:WP511]]: Moved to stable identifier
12012view08:43, 15 May 2008MaintBotAdded to category $category
12010view08:43, 15 May 2008MaintBotUploaded new pathway

External references


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NameTypeDatabase referenceComment
ApoptosisPathwayWP254 (WikiPathways)
CeramideMetabolite104404-17-3 (CAS)
GlutathioneMetaboliteHMDB0000125 (HMDB)
LOC100334486GeneProduct100334486 (Entrez Gene)
PhosphateMetaboliteHMDB0001429 (HMDB)
apaf1GeneProduct58131 (Entrez Gene)
arhgdigGeneProduct394132 (Entrez Gene) Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
casp6GeneProduct552927 (Entrez Gene)
casp7GeneProduct553634 (Entrez Gene)
casp8GeneProduct58022 (Entrez Gene)
casp8l2GeneProduct557302 (Entrez Gene)
casp9GeneProduct492763 (Entrez Gene)
cflarGeneProduct373114 (Entrez Gene)
cycsbGeneProduct415158 (Entrez Gene)
daxxGeneProduct561006 (Entrez Gene)
dffaGeneProduct436904 (Entrez Gene)
dffbGeneProduct373130 (Entrez Gene)
faddGeneProduct562317 (Entrez Gene)
faf1GeneProduct406243 (Entrez Gene)
fasGeneProduct768248 (Entrez Gene)
faslgGeneProduct735295 (Entrez Gene)
hspb1GeneProduct368243 (Entrez Gene)
junGeneProduct335916 (Entrez Gene)
lmnaGeneProduct195815 (Entrez Gene)
lmnb1GeneProduct195816 (Entrez Gene)
lmnb2GeneProduct30196 (Entrez Gene)
map2k4aGeneProduct403052 (Entrez Gene)
map3k7GeneProduct553788 (Entrez Gene)
mapk8aGeneProduct562720 (Entrez Gene)
mapkapk2aGeneProduct327321 (Entrez Gene)
mapkapk3GeneProduct790934 (Entrez Gene)
pak1GeneProduct373103 (Entrez Gene)
pak2aGeneProduct266749 (Entrez Gene)
parp1GeneProduct560788 (Entrez Gene)
rb1GeneProduct777733 (Entrez Gene)
ripk2GeneProduct373874 (Entrez Gene) receptor (TNFRSF)-interacting serine-threonine kinase 2
spna2GeneProduct553383 (Entrez Gene) Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
wu:fa96e12GeneProduct562283 (Entrez Gene)

Annotated Interactions

No annotated interactions
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