Malignant pleural mesothelioma (Homo sapiens)

From WikiPathways

Jump to: navigation, search
14-3-314-3-3232012, 2323232623231226333391919193323323310193433232693263319232320, 2319319561116161111261118248111681611616161612681616112116881, 61817611616861117111161626686617111126TAMsMMChronic inflammation, proliferation, angiogenesis,resistance to apoptosisClea this. Some GFs bind particular RTKsIntegrinsLAT1JNKsCollagenolysisa-cateninCancer-associated fibroblastsGrowth arrestAMPKTumorigenesis & ProliferationIntegrinsMesothelial cellWNT pathwayWnt signalRTKsTranscriptionDegradationHippo-Merlin signalingStiff and fibronectin rich ECMOther chemokines/cytokinesUbiquination degradationMAPK pathwayInflammatory cytokines,cellular stressesCell survivalInflammationCell growth,differentiationChemokines, Cytokines,Pro-angiogenic factorsAutophagyMDM2-P53 signalingChemokines/Cytokines etc.MetastasisAngiogenesisDNA methylationGenetic aberrationsCell survival & growthReplicative immortalityAP-1 dependent genes/Repair genesCadherinsCell growthmTOR pathwayIncreased protein synthesis+ Cell growthDNA-damageMAPK and JAK-STAT pathwaysCCND1RAFIL10ITGA1TGFB1AREGCSF1FGF1IL6HGFTGFAFOXM1let-7CCL2PDGFRALIN28BPD-L1ITGB1LAMC1LGALS9VGLL4FGF2ACTA1LIMD1SLC3A2CD44FGFR1IGF1CTNNA1CCL2MYCCXCL12EGFRKITACTA2CTGFKITLGHGFHBEGFVEGFACSF2ACTBPLCB4METCTGFMAPK8LAMA1SLC2A1IGF1RIDO1BTCFN1COL4A1FGF2glucose2312, 23CDK4Histone modificationsP53DVLTCFBCL2CDKN2A2BAXRAGECyclinE14-3-3HIF1APIP3MCL1MMP9CDK7PDK1ASKNF2RASNF-KBS6DNA repairPRAS40DEPTORSFRPMEK5GRB2TSC1CUL1ATMSTATSP1S6KROSMAPK14SHCAPCTEL2FZDSAV1ERK2MEKKLATS1ATG13JAKP21CDK2Cell cycleSETD2MSKAngiogenesisULK221HMGB1c-fosMMP2MEK4/7E2FLATS221PDGFGDPBTRCMAXKIBRACyclin DGABPACTNNB1AKTIL-1BFOXO1PUMAMST1MSIN1RICTORERK1/2EIF4c-junNLRP3DKK1P16INK4ALEFVEGFFAKRHEBMDM2AJUBAMNKSETD5RSKMEK1/2MLKPIGFfra-1TEAD1TSC2PIP2GSK3CASPASE-1AMOTAXINRNSc-MycDR54E-BPSRCLRPBAP1MTORRAPTORPTENERK5MEK3/6TERT7, 13BECLIN1MKGTPBAKApoptosisMYCULK1SETDB1MLST8MAD1BCLXLPRBPI3Kp14ARFSOSTTI1STATAP2CyclinD1FIP200RASMSKMNKMKTEL2TTI1MLST8DEPTORMTORYAPTAZMDM2P21BAXCTNNB1Cell transformationE2FPRBHMGB1HMGB1PRAS40RAPTORTEL2TTI1MLST8DEPTORMTORHMGB1IL-1BPro IL-1BP21YAPTAZChemokines, Cytokines,Pro-angiogenic factorsCell survival1Wnt signalingAutophagyCell migrationNucleusCTNNB1CTNNB1NF-KBSRCNF2PAK1PAK2PAK3PAK4PAK5PAK626MAPK signaling pathwayMicroenvironment interactionsAngiogenesisVEGFBVEGFCVEGFD23TGFB1IL6PDGFAPDGFBPDGFCPDGFDMMP2MMP315MMP915MMP14EGF22FGFR2FGFR3FGFR433IGF23METPDGFRB23COL4A2COL4A312, 23COL4A4COL4A5COL4A6LAMA2LAMA3LAMA4LAMA5LAMB1LAMB2LAMB3LAMC2LAMC3ITGA2ITGA3ITGA4ITGAVITGA6ITGB2ITGB3ITGB4LamininsFN123COL4A1COL4A2COL4A3COL4A423COL4A5COL4A6LAMA1LAMC1LAMA2LAMA3LAMA4LAMA5LAMB1LAMB2LAMB3LAMC2LAMC3CCL4CXCL10CXCL5CXCL12TGFB1VEGFAVEGFBVEGFCVEGFDglucoseSLC7A5ArginineArginineTryptophanTryptophanKynurenineTumor-associated macrophagesIL34PhagocytosisCXCL5CXCL12TGFB1T-LymphocytesCXCL5CXCL1IL6CXCL12CSF3PD-L1IL10Myeloid-Derived Suppressor Cellsprostaglandin E2CDH5CDH1CDH10CDH17CDH9CDH16CDH6CDH13CDH20CDH2CDH19CDH22CDH8CDH24CDH18CDH12CDH7CDH15CDH11CDH3CDH4PRKAB2PRKAB1PRKAA2PRKAG1PRKAA1PRKAG2PRKAG3FGFR2KDRINSRFGFR3IGF1RKITFGFR1EPHA2EGFRCSF1RFGFR4FLT1FLT4NGFRMETPDGFRAPDGFRBTEKFLT3NTRK1NTRK2RASMOB1AEFNA1FGF1FGF11FGF10EFNA2EGFFGF12CSF1ANGPT4ANGPT2ANGPT1VEGFAEFNA3EFNA4EFNA5FGF14FGF5FGF19FGF17FGF18FGF2FGF3FGF4FGF6FGF7FGF8FGF9VEGFDHGFIGF1IGF2INSKITLGKik1b4FLT3LGVEGFCVEGFBPDGFBPGFPDGFANGFPDGFCFGF21FGF23FGF22PDGFDFGF20FGF13Growth FactorFGF19NTF3NTF4BDNFTGFAROSVEGFAVEGFBVEGFCVEGFD20CCL5CD47ACTC1ACTG1ACTG2ITGB1ITGA1ITGA2ITGA3ITGA4ITGAVITGA6CTNNA2CTNNA3B1-integrinExplore this integrin and how this affects NF2MOB1BTAZTEAD2TEAD3TEAD4Add phosphorilation steps by MST1/2 and map4ks26STK3MAPK9MAPK10MAPK8MAPK9MAPK10JNKs26Functions of MMPs