Fatty acid transporters (Homo sapiens)

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1-7HeartIntestineLiverBrainMammary glandTestiskidneyPlacentaOvaryLungGonadsSpleenAdipocytesCOENZYME AACSL3FABP1LCFAsFABP1FABP2SLC27A4FABP9ACSL6ACSL4ACSBG1SLC27A3CD36FABP3SLC27A6ACSL1FABP5FABP4ACSBG1DBISLC27A5FABP3SLC27A2FABP7CD36CD36CD36CD36CD36SLC27A1ACSL3ACSL5ACSL1ACSL1LCFAsLCFAsLCFAsLCFAsLCFAsLCFAsSLC27A1SLC27A4SLC27A2ACSL4ACSL5SLC27A3SLC27A4SLC27A3CD36LCFAsCD36SLC27A4ACSL6ACSBG1ACSL3LCFAsACSBG1LCFAsSLC27A3CD36CD36SLC27A3ACSBG2LCFAsCOENZYME ACOENZYME ACOENZYME ACOENZYME ACOENZYME ACOENZYME ACOENZYME ACOENZYME ACOENZYME AFABP5FABP1FABP5FABP5FABP6FABP3DBIDBIDBIDBIDBIDBIDBIDBIDBIFABP3FABP5FABP5FABP1FABP5FABP6FABP2FABP5FABP3FABP3FABP7FABP9FABP5FABP3FABP5FABP3FABP5


Description

This transport pathway shows several tissue specific fatty acid transport proteins (FATP), which facilitate fatty acid uptake. The extracellular fatty acids can either bind to CD36 or bind directly to the fatty acid transporters. When the fatty acids have entered the cell, they can either be coupled to Acyl-CoA by long-chain fatty acyl-CoA synthetases or bind to fatty acid binding proteins (FABPs). This binding of the fatty acids to CoA or FABPs prevents the efflux of the fatty acids.

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Ontology Terms

 

Bibliography

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  1. Stahl A; ''A current review of fatty acid transportproteins (SLC27).''; Pflugers Arch, 2004 PubMed Europe PMC Scholia
  2. Mashek DG, Li LO, Coleman RA; ''Long-chain acyl-CoA synthetases and fatty acid channeling.''; Future Lipidol, 2007 PubMed Europe PMC Scholia
  3. Hanhoff T, Lücke C, Spener F; ''Insights into binding of fatty acids by fatty acid binding proteins.''; Mol Cell Biochem, 2002 PubMed Europe PMC Scholia
  4. Smathers RL, Petersen DR; ''The human fatty acid-binding protein family: evolutionary divergences and functions.''; Hum Genomics, 2011 PubMed Europe PMC Scholia
  5. Padanad MS, Konstantinidou G, Venkateswaran N, Melegari M, Rindhe S, Mitsche M, Yang C, Batten K, Huffman KE, Liu J, Tang X, Rodriguez-Canales J, Kalhor N, Shay JW, Minna JD, McDonald J, Wistuba II, DeBerardinis RJ, Scaglioni PP; ''Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis.''; Cell Rep, 2016 PubMed Europe PMC Scholia
  6. Guthmann F, Hohoff C, Fechner H, Humbert P, Börchers T, Spener F, Rüstow B; ''Expression of fatty-acid-binding proteins in cells involved in lung-specific lipid metabolism.''; Eur J Biochem, 1998 PubMed Europe PMC Scholia
  7. Chmurzyńska A; ''The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism.''; J Appl Genet, 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
115541view14:54, 26 February 2021Jkearns445Modified description
115538view14:04, 26 February 2021Jkearns445
115537view13:57, 26 February 2021Jkearns445
115534view10:41, 26 February 2021Jkearns445Ontology Term : 'transport pathway' added !
115533view10:34, 26 February 2021Jkearns445
115527view16:49, 25 February 2021Jkearns445New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACSBG1GeneProductENSG00000103740 (Ensembl)
ACSBG2GeneProductENSG00000130377 (Ensembl)
ACSL1GeneProductENSG00000151726 (Ensembl)
ACSL3GeneProductENSG00000123983 (Ensembl)
ACSL4GeneProductENSG00000068366 (Ensembl)
ACSL5GeneProductENSG00000197142 (Ensembl)
ACSL6GeneProductENSG00000164398 (Ensembl)
CD36GeneProductENSG00000135218 (Ensembl)
COENZYME AMetaboliteCHEBI:15346 (ChEBI)
DBIGeneProductENSG00000155368 (Ensembl)
FABP1GeneProductENSG00000163586 (Ensembl)
FABP1GeneProductHGNC:3555 (HGNC)
FABP2GeneProductENSG00000145384 (Ensembl)
FABP3GeneProductENSG00000121769 (Ensembl)
FABP4GeneProductENSG00000170323 (Ensembl)
FABP5GeneProductENSG00000164687 (Ensembl)
FABP6GeneProductENSG00000170231 (Ensembl)
FABP7GeneProductENSG00000164434 (Ensembl)
FABP9GeneProductENSG00000205186 (Ensembl)
LCFAsMetaboliteCHEBI:15904 (ChEBI)
SLC27A1 GeneProductHGNC:10995 (HGNC)
SLC27A2 GeneProductHGNC:10996 (HGNC)
SLC27A3 GeneProductHGNC:10997 (HGNC)
SLC27A4GeneProductENSG00000167114 (Ensembl)
SLC27A4GeneProductSLC27A4 (HGNC)
SLC27A5GeneProductHGNC:10999 (HGNC)
SLC27A6 GeneProductHGNC:11000 (HGNC)

Annotated Interactions

No annotated interactions

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