Fluoroacetic acid toxicity (Homo sapiens)

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1Aldehyde dehydrogenasesAconitase4-Hydroxy-trans-aconitateCytric acid cycle (Krebs cycle)Citric acidFluoroacetic acidALDH2Acetyl-CoA synthetaseCitrate synthaseFluoroacetaldehydeALDH9A1ALDH3A2AcetateIsocitric acidFluoroacetyl-CoAFluorocitric acid


Pathway on fluoroacetic acid toxicity describing how it ultimately leads to disturbance of the Krebs cycle.

Quality Tags

Ontology Terms



  1. Johnson BM, Shu YZ, Zhuo X, Meanwell NA; ''Metabolic and Pharmaceutical Aspects of Fluorinated Compounds.''; J Med Chem, 2020 PubMed Europe PMC Scholia


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112070view10:14, 18 September 2020Marvin M2Ontology Term : 'altered metabolic pathway' added !
112069view10:14, 18 September 2020Marvin M2Ontology Term : 'altered citric acid cycle pathway' added !
112068view10:13, 18 September 2020DeSlOntology Term : 'disease pathway' added !
112067view10:09, 18 September 2020Marvin M2Added reference and minor layout edit
111923view06:49, 11 September 2020EgonwAdded the missing compound identifier.
111922view06:22, 11 September 2020EgonwModified description
111816view19:16, 8 September 2020Marvin M2changed secondary chebi IDs to primary chebi IDs.
111786view14:17, 7 September 2020Marvin M2New pathway

External references


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NameTypeDatabase referenceComment
4-Hydroxy-trans-aconitateMetaboliteQ76106265 (Wikidata)
ALDH2GeneProductENSG00000111275 (Ensembl)
ALDH3A2GeneProductENSG00000072210 (Ensembl)
ALDH9A1GeneProductENSG00000143149 (Ensembl)
AcetateMetabolite71-50-1 (CAS)
Acetyl-CoA synthetaseGeneProductENSG00000131069 (Ensembl)
AconitaseGeneProductENSG00000100412 (Ensembl)
Citrate synthaseGeneProduct1431 (Entrez Gene)
Citric acidMetaboliteCHEBI:30769 (ChEBI)
Cytric acid cycle (Krebs cycle)PathwayWP78 (WikiPathways)
FluoroacetaldehydeMetaboliteCHEBI:14272 (ChEBI)
Fluoroacetic acidMetaboliteCHEBI:30775 (ChEBI)
Fluoroacetyl-CoAMetabolite49859653 (PubChem-compound)
Fluorocitric acidMetabolite357-89-1 (CAS)
Isocitric acidMetaboliteCHEBI:30887 (ChEBI)

Annotated Interactions

No annotated interactions

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