Fluoroacetic acid toxicity (Homo sapiens)

From WikiPathways

Revision as of 10:13, 18 September 2020 by DeSl (Talk | contribs)
Jump to: navigation, search
1Aldehyde dehydrogenasesAcetateFluoroacetyl-CoACitrate synthaseALDH9A1Citric acid4-Hydroxy-trans-aconitateIsocitric acidAconitaseALDH2Acetyl-CoA synthetaseCytric acid cycle (Krebs cycle)FluoroacetaldehydeFluoroacetic acidALDH3A2Fluorocitric acid


Description

Pathway on fluoroacetic acid toxicity describing how it ultimately leads to disturbance of the Krebs cycle.

Quality Tags

Ontology Terms

 

Bibliography

  1. Johnson BM, Shu YZ, Zhuo X, Meanwell NA; ''Metabolic and Pharmaceutical Aspects of Fluorinated Compounds.''; J Med Chem, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
112070view10:14, 18 September 2020Marvin M2Ontology Term : 'altered metabolic pathway' added !
112069view10:14, 18 September 2020Marvin M2Ontology Term : 'altered citric acid cycle pathway' added !
112068view10:13, 18 September 2020DeSlOntology Term : 'disease pathway' added !
112067view10:09, 18 September 2020Marvin M2Added reference and minor layout edit
111923view06:49, 11 September 2020EgonwAdded the missing compound identifier.
111922view06:22, 11 September 2020EgonwModified description
111816view19:16, 8 September 2020Marvin M2changed secondary chebi IDs to primary chebi IDs.
111786view14:17, 7 September 2020Marvin M2New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
4-Hydroxy-trans-aconitateMetaboliteQ76106265 (Wikidata)
ALDH2GeneProductENSG00000111275 (Ensembl)
ALDH3A2GeneProductENSG00000072210 (Ensembl)
ALDH9A1GeneProductENSG00000143149 (Ensembl)
AcetateMetabolite71-50-1 (CAS)
Acetyl-CoA synthetaseGeneProductENSG00000131069 (Ensembl)
AconitaseGeneProductENSG00000100412 (Ensembl)
Citrate synthaseGeneProduct1431 (Entrez Gene)
Citric acidMetaboliteCHEBI:30769 (ChEBI)
Cytric acid cycle (Krebs cycle)PathwayWP78 (WikiPathways)
FluoroacetaldehydeMetaboliteCHEBI:14272 (ChEBI)
Fluoroacetic acidMetaboliteCHEBI:30775 (ChEBI)
Fluoroacetyl-CoAMetabolite49859653 (PubChem-compound)
Fluorocitric acidMetabolite357-89-1 (CAS)
Isocitric acidMetaboliteCHEBI:30887 (ChEBI)

Annotated Interactions

No annotated interactions

Personal tools