Glucocorticoid & Mineralcorticoid Metabolism (Mus musculus)

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OH17a,21-Dihydroxy-5b-2CHPregnane-3,11,20-trioneCortisol*HO*=OCHHOO=OPregnane 3,20-dioneCCCHO=OGlucocorticoidsHOOH2CHCortoloneHOUrocortisolTo Androgen Synthesisand MetabolismHOOO=OCFrom Cholersterol Biosynthesis3CH2*COHHOOHhave strucutures shown5b-Pregnane-3,20-dioneCCH3=OCH33B-OH-delta-Steroid DhCHUrocortisone11-DeoxycorticosteroneCHCortisolSubstrates inOH=O11b,17a 21-Trihydroxy-5bC11-DeoxycortisolOProgesterone DegradationOCortisoneGlucuronides-OH3Steroid HormoneSignaling3O3a,11b,21-Trihydroxy-20-Oxo-5b-Pregnan-18-alCHHCHOHteal=O11b, 21-Dihydroxy-3,20-5b-Pregnan-18-alCyp11b2Hsd3b13alpha-Hydroxy-5beta-pregnane-20-one20b-Hydroxysteroid DhAkr1c21Hsd3b1Hsd3b1Corticosterone18-HydroxycorticosteroneHsd3b2CholesterolCyp17a1Cyp11a1Cyp11b2Hsd3b6PregnanediolHsd3b5Hsd3b417a-Hydroxypregnenolone3a-Hydroxysteroid DhProgesteronePregnenoloneHsd3b33-Oxo-5b-Steroid DhHsd11b217-a-HydroxyprogesteroneCyp21a1Cyp17a1Cortisone beta-reductaseAldosteroneHsd11b1(R)20-hydroxysteroid Dh


Description

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Comments

GenMAPP remarks 
Adapted from http://au.expasy.org/tools/pathways/

Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
106899view13:37, 17 September 2019MaintBotHMDB identifier normalization
71740view20:18, 17 October 2013MaintBotAutomated update of data sources
71325view17:17, 17 October 2013MaintBotAutomated update of data sources
69138view18:16, 8 July 2013MaintBotUpdated to 2013 gpml schema
67283view10:31, 26 June 2013Christine ChichesterOntology Term : 'C21-steroid hormone biosynthetic pathway' added !
62838view04:59, 3 May 2013MaintBotUpdated UniProt data source
41327view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
33388view14:43, 30 November 2009MaintBotRemoved group label
32963view21:54, 28 September 2009MaintBotPeriodical save, work in progress
32962view21:23, 28 September 2009MaintBotAdded metabolites and connectors
32961view21:10, 28 September 2009MaintBotadded metabolites and connectors
32960view21:05, 28 September 2009MaintBotPeriodical save, work in progress
32959view20:55, 28 September 2009MaintBotPeriodical save, work in progress
21720view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Glucocorticoid Mineralocorticoid Metabolism]] moved to [[Pathway:WP495]]: Moved to stable identifier
8080view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Glucocorticoid Mineralocorticoid Metabolism]] moved to [[Pathway:Mus musculus:Glucocorticoid Mineralocorticoid Metabolism]]: Renaming species
7662view16:08, 18 December 2007MaintBotfixed category names
7361view12:42, 4 November 2007MaintBotAdded categories to GPML
7108view13:20, 10 October 2007MichielSpecify description
7107view13:19, 10 October 2007MichielSpecify description
7106view13:17, 10 October 2007Michieltest
7105view13:15, 10 October 2007Michieltest
7101view12:57, 10 October 2007MichielTest
19472view22:19, 22 May 2007M.Liebermangpml file for [[Mouse:Glucocorticoid_Mineralocorticoid_Metabolism]]
6450view22:19, 22 May 2007Nsalomonisgpml file for [[Mouse:Glucocorticoid_Mineralocorticoid_Metabolism]]

External references

DataNodes

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NameTypeDatabase referenceComment
(R)20-hydroxysteroid DhGeneProduct
17-a-HydroxyprogesteroneMetabolite
17a-HydroxypregnenoloneMetaboliteHMDB00363 (HMDB)
18-HydroxycorticosteroneMetaboliteHMDB00319 (HMDB)
20b-Hydroxysteroid DhGeneProduct
3-Oxo-5b-Steroid DhGeneProduct
3a-Hydroxysteroid DhGeneProduct
3alpha-Hydroxy-5beta-pregnane-20-oneMetaboliteHMDB06759 (HMDB)
Akr1c21GeneProduct77337 (Entrez Gene) SP, mouse EST: AW611181, rat SP: DIDH RAT
AldosteroneMetaboliteHMDB00037 (HMDB)
CholesterolMetaboliteHMDB00067 (HMDB)
CorticosteroneMetaboliteHMDB01547 (HMDB)
Cortisone beta-reductaseGeneProduct
Cyp11a1GeneProduct13070 (Entrez Gene)
Cyp11b2GeneProduct13072 (Entrez Gene) EC number: 1.14.15.5
Cyp17a1GeneProduct13074 (Entrez Gene)
Cyp21a1GeneProduct13079 (Entrez Gene)
Hsd11b1GeneProduct15483 (Entrez Gene)
Hsd11b2GeneProduct15484 (Entrez Gene)
Hsd3b1GeneProduct15492 (Entrez Gene)
Hsd3b2GeneProduct15493 (Entrez Gene)
Hsd3b3GeneProduct15494 (Entrez Gene)
Hsd3b4GeneProduct15495 (Entrez Gene)
Hsd3b5GeneProduct15496 (Entrez Gene)
Hsd3b6GeneProduct15497 (Entrez Gene)
PregnanediolMetaboliteHMDB04025 (HMDB)
PregnenoloneMetaboliteHMDB00253 (HMDB)
ProgesteroneMetaboliteHMDB01830 (HMDB)

Annotated Interactions

No annotated interactions
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