Mitochondrial Complex I inhibition leading to parkinsonian motor deficits (Homo sapiens)

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1KE888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)MMP+Decreased mitochondrial oxidative phosphorylationAssembly of mitochondrial complex IImpaired proteostasisUnfolded Protein ResponseRotenoneKE887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)KE177: N/A, Mitochondrial dysfunction 1KE889: Impaired, ProteostasisDegeneration of DA neurons of nigrostratial pathwayParkinsonian motor deficitsNeuroinflammationKE188: N/A, NeuroinflammationKE890: Degeneration of dopaminergic neurons of the nigrostriatal pathwayKE896: Parkinsonian motor deficits


Description

This pathway is a meta-pathway that represents an updated version of the Adverse Outcome Pathway (AOP) of Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits AOP-Wiki:3. All Key Events are present as Key Event nodes, with their corresponding molecular pathways as pathway nodes.

Quality Tags

Ontology Terms

 

Bibliography

  1. Terron A, Bal-Price A, Paini A, Monnet-Tschudi F, Bennekou SH, Leist M, Schildknecht S; ''An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition.''; Arch Toxicol, 2018 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
111510view09:58, 21 August 2020Marvin M2Ungrouped for nicer network merging
111507view09:51, 21 August 2020Marvin M2changed connections in groups
111425view11:32, 7 August 2020Marvin M2
111423view11:14, 7 August 2020Marvin M2Modified description
111422view11:13, 7 August 2020Marvin M2Added literature reference
111421view11:02, 7 August 2020Marvin M2Ontology Term : 'altered energy metabolic pathway' added !
111420view10:38, 7 August 2020Marvin M2Ontology Term : 'Parkinson's disease' added !
111419view10:37, 7 August 2020Marvin M2Ontology Term : 'DOID:0060897' removed !
111418view10:37, 7 August 2020Marvin M2Ontology Term : 'Parkinson disease 17' added !
111417view10:36, 7 August 2020Marvin M2Modified description
111078view13:48, 6 July 2020Marvin M2New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Assembly of mitochondrial complex IPathwayWP4324 (WikiPathways)
Decreased mitochondrial oxidative phosphorylationPathwayWP111 (WikiPathways)
Degeneration of DA neurons of nigrostratial pathwayPathwayWP2855 (WikiPathways)
Impaired proteostasisPathwayWP4918 (WikiPathways)
KE177: N/A, Mitochondrial dysfunction 1Key Event177 (AOP-Wiki KE)
KE188: N/A, NeuroinflammationKey Event188 (AOP-Wiki KE)
KE887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)Key Event887 (AOP-Wiki KE)
KE888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)Key Event888 (AOP-Wiki KE)
KE889: Impaired, Proteostasis Key Event889 (AOP-Wiki KE)
KE890: Degeneration of dopaminergic neurons of the nigrostriatal pathwayKey Event890 (AOP-Wiki KE)
KE896: Parkinsonian motor deficitsKey Event896 (AOP-Wiki KE)
MMP+Stressor222 (AOP-Wiki Stressor)
NeuroinflammationPathwayWP4919 (WikiPathways)
Parkinsonian motor deficitsPathwayWP2371 (WikiPathways)
RotenoneStressor50 (AOP-Wiki Stressor)
Unfolded Protein ResponsePathwayWP4925 (WikiPathways)

Annotated Interactions

No annotated interactions

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