Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2 (Homo sapiens)

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Autophagosome/Autophagy receptors HOPS COMPLEXLegendPhospho(S/T) siteAccumulation of autophagy receptors HOPS COMPLEXSNAREsPhagophorecargo sequestrationAKT1PKMVPS18VPS36ATG3ORF3TSC2MTORVPS33ATAX1BP1LARP1ULK1VPS11MTORATG12RPS6AKT1S1MAP1LC3BRPTORATG5ATG7RHEBATG13ATG9AOPTNAMPKRPTORGSK3AKT1S1PPP1R9AATG4ACALCOCO2ATG16LGABARAPL2MLST8MLST8VPS41RAB7AP70S6KFIP200ORF3VPS16SQSTM1DEPTORT525S1347S238K74K82S735S240S479K281S738T269T1162K435S638S766K143S203 S366K97S272K24S18S355K157S202K149 S361S477K46LysosomeAutophagolysosomeFusionLate endosomeUbiqutination (K) siteBindingInteractionUpregulationSARS-CoV-2 proteinInhibitionNSP61DEPTOR


Description

Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2, derived from the network diffusion model and overlaid with the changes in protein levels, ubiquitination and phosphorylation induced by SARS-CoV-2 infection.

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Ontology Terms

 

Bibliography

  1. Alexey Stukalov, Virginie Girault, Vincent Grass, Valter Bergant, Ozge Karayel, Christian Urban, Darya A. Haas, Yiqi Huang, Lila Oubraham, Anqi Wang, Sabri M. Hamad, Antonio Piras, Maria Tanzer, Fynn M. Hansen, Thomas Enghleitner, Maria Reinecke, Teresa M. Lavacca, Rosina Ehmann, Roman Wölfel, Jörg Jores, Bernhard Kuster, Ulrike Protzer, Roland Rad, John Ziebuhr, Volker Thiel, Pietro Scaturro, Matthias Mann, Andreas Pichlmair; ''Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV''; https://doi.org/10.1101/2020.06.17.156455, 2020

History

View all...
CompareRevisionActionTimeUserComment
115858view15:54, 18 March 2021Marvin M2Changed legend to graphical elements
115855view15:44, 18 March 2021Marvin M2added annotations
115839view14:52, 18 March 2021Marvin M2corrected ref
115836view14:35, 18 March 2021Marvin M2connected lines, some annotations
114087view08:27, 21 December 2020EgonwTyped 'phagophore' and give it an identifier
114075view06:17, 21 December 2020EgonwConverted a label involved in an interaction into a DataNode
112887view13:08, 15 October 2020Fehrhartfixed unconnected lines
111196view04:21, 24 July 2020Rex D A BConnections
111139view16:37, 17 July 2020EgonwColored the proteins according to the COVID19 Disease Maps convention
111028view06:22, 1 July 2020EgonwUpdated the UniProt data source
110916view04:32, 21 June 2020Rex D A BOntology Term : 'altered autophagy pathway' added !
110915view04:30, 21 June 2020Rex D A BOntology Term : 'infectious disease pathway' added !
110914view04:18, 21 June 2020Rex D A BModified description
110913view04:17, 21 June 2020Rex D A BNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1ProteinP31749 (Uniprot-TrEMBL)
AKT1S1GeneProductENSG00000204673 (Ensembl)
AMPKProtein5563 (NCBI Protein)
ATG12Protein9140 (NCBI Protein)
ATG13Protein9776 (NCBI Protein)
ATG16LProtein55054 (NCBI Protein)
ATG3Protein64422 (NCBI Protein)
ATG4AGeneProductENSG00000101844 (Ensembl)
ATG5Protein9474 (NCBI Protein)
ATG7Protein10533 (NCBI Protein)
ATG9AProtein79065 (NCBI Protein)
CALCOCO2Protein10241 (NCBI Protein)
DEPTORProtein64798 (NCBI Protein)
FIP200Protein9821 (NCBI Protein)
GABARAPL2Protein11345 (NCBI Protein)
GSK3ProteinP31749 (NCBI Protein)
LARP1GeneProductENSG00000155506 (Ensembl)
MAP1LC3BGeneProduct81631 (NCBI Protein)
MLST8Protein64223 (NCBI Protein)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORProtein2475 (NCBI Protein)
MTORGeneProductENSG00000198793 (Ensembl)
NSP6ProteinYP_009725302 (NCBI Protein)
OPTNProtein10133 (NCBI Protein)
ORF3GeneProductORF3 has no identifiers. ORF3a and ORF3b do, but it's not clear which one(s) to use
ORF3GeneProductORF3
P70S6KGeneProductENSG00000108443 (Ensembl)
PKMProtein5315 (NCBI Protein)
PPP1R9AGeneProductENSG00000158528 (Ensembl) Also known as NRB1
PhagophoreCellularComponentQ34360359 (Wikidata)
RAB7AProtein7879 (NCBI Protein)
RHEBProtein6009 (NCBI Protein)
RPS6Protein6194 (NCBI Protein)
RPTORProtein57521 (NCBI Protein)
RPTORGeneProductENSG00000141564 (Ensembl)
SQSTM1Protein8878 (NCBI Protein)
TAX1BP1Protein8887 (NCBI Protein)
TSC2ProteinP31749 (NCBI Protein)
ULK1Protein8408 (NCBI Protein)
VPS11Protein55823 (NCBI Protein)
VPS16Protein64601 (NCBI Protein)
VPS18GeneProductENSG00000104142 (Ensembl)
VPS33AProtein65082 (NCBI Protein)
VPS36Protein51028 (NCBI Protein)
VPS41Protein27072 (NCBI Protein)

Annotated Interactions

No annotated interactions

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