Unfolded protein response (Homo sapiens)

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1ERmiRNAsXBP1(s) activated chaperone genesmRNAsmiRNAsCytosolRegulated IRE1-dependent decayNLRP3inflammasomeATF6 activated chaperone genesSterileinflammationXBP1ApoptosisCHOPEIF2S1Caspase-2BCL2L11PMAIP1GADD35p53MBTPS2RTCBPERKATF4BBC3BCL2NFE2L2BIDTNFRSF10BBiPATF4MBTPS1IRE1αATF6Caspase-1TXNIPIL1BROSCaspase-8ATF6GADD35PMAIP1BBC3BCL2L11TNFRSF10BTNFRSF10B


Description

The Unfolded Protein Response (UPR) pathway regulates and protects the cell from improperly folded protein overload in the Endoplasmic Reticulum (ER). The UPR can result in the slowing of protein synthesis, which gives the cell time to translate more chaperones to help process the proteins. If the stress is too high, the UPR can eventually trigger apoptosis.

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Ontology Terms

 

Bibliography

  1. Hetz C, Papa FR; ''The Unfolded Protein Response and Cell Fate Control.''; Mol Cell, 2018 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
110553view10:18, 18 May 2020Fehrhartfixed unconnected lines
110415view11:55, 9 May 2020EgonwNot a mim-conversion
110414view11:30, 9 May 2020Egonw
110410view08:33, 9 May 2020AnnabayaAdd reference
110409view08:31, 9 May 2020AnnabayaOntology Term : 'endoplasmic reticulum stress - the unfolded protein response pathway' added !
110408view08:30, 9 May 2020AnnabayaNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ATF4GeneProductENSG00000128272 (Ensembl)
ATF6GeneProductENSG00000118217 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
BBC3GeneProductENSG00000105327 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BCL2L11GeneProductENSG00000153094 (Ensembl)
BIDGeneProductENSG00000015475 (Ensembl)
BiPGeneProductENSG00000044574 (Ensembl)
CHOPGeneProductENSG00000175197 (Ensembl)
Caspase-1ProteinA0A1W2PRX7 (Uniprot-TrEMBL)
Caspase-2ProteinA0A087WYM1 (Uniprot-TrEMBL)
Caspase-8ProteinA0A0A0MS31 (Uniprot-TrEMBL)
EIF2S1GeneProductENSG00000134001 (Ensembl)
GADD35GeneProductENSG00000087074 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IRE1αGeneProductENSG00000178607 (Ensembl)
MBTPS1GeneProductENSG00000140943 (Ensembl)
MBTPS2GeneProductENSG00000012174 (Ensembl)
NFE2L2GeneProductENSG00000116044 (Ensembl)
PERKGeneProductENSG00000172071 (Ensembl)
PMAIP1GeneProductENSG00000141682 (Ensembl)
ROSPathwayWP3941 (WikiPathways)
RTCBGeneProductENSG00000100220 (Ensembl)
TNFRSF10BGeneProductENSG00000120889 (Ensembl)
TXNIPGeneProductENSG00000265972 (Ensembl)
XBP1GeneProductENSG00000100219 (Ensembl)
p53GeneProductENSG00000141510 (Ensembl)

Annotated Interactions

No annotated interactions

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