Autophagy (Homo sapiens)

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1, 24OmegasomeInitiationAtophagosomeULK1 complexFormationAMPKLysosomePhagophoremTORC1PtdIns3K complexPRKAA1ATG101PRKAA2PEPRKAB1UVRAGATG7PRKAG3ATG5PIK3C3ATG12RB1CC1PRKAB2DEPTORPRKAG2RPTORPIK3C3MAP1LC3BATG14PRKAG1ATG9AAKT1S1ATG13ULK1MLST8ATG3AMBRA1MTORPtdIns3PATG16L1WIPI2PIK3R4BECN13BECN1PIK3R4ATG9AMAP1LC3BPtdIns3PMAP1LC3BMembrane expansionPhagophoreATG9AAutolysosomeMaturation


Description

Autophagy is a type of process that cell allows itself to degrade intracellular components, including organelles, proteins and foreign bodies. Autophagy is inhibited by mTORC1 and activated by AMPK. The process requires four steps: initiation, formation, membrane expansion and maturation, which are characterised by the structures that are roughly represented by the structures that are present: the omegasome, phagophore, atophagosome and finally autolysosme. It requires formation of the autophagosome, a double-membrane structure filled with the isolated cytoplasmic material that the cell wants to remove. The autophagosome eventually fuses with the lysosome to form the autolysosome.

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Ontology Terms

 

Bibliography

  1. Kim BW, Jin Y, Kim J, Kim JH, Jung J, Kang S, Kim IY, Cheong H, Song HK; ''''; , PubMed Europe PMC Scholia
  2. Yu L, Chen Y, Tooze SA; ''Autophagy pathway: Cellular and molecular mechanisms.''; Autophagy, 2018 PubMed Europe PMC Scholia
  3. Tamargo-Gómez I, Mariño G; ''AMPK: Regulation of Metabolic Dynamics in the Context of Autophagy.''; Int J Mol Sci, 2018 PubMed Europe PMC Scholia
  4. Jang M, Park R, Kim H, Namkoong S, Jo D, Huh YH, Jang IS, Lee JI, Park J; ''AMPK contributes to autophagosome maturation and lysosomal fusion.''; Sci Rep, 2018 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
110416view13:48, 9 May 2020AnnabayaFixed spelling
110385view15:55, 8 May 2020AnnabayaOntology Term : 'autophagy pathway' added !
110384view15:54, 8 May 2020AnnabayaModified description
110372view15:23, 8 May 2020AnnabayaOntology Term : 'cell death pathway' added !
110365view09:58, 8 May 2020AnnabayaNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1S1GeneProductENSG00000204673 (Ensembl)
AMBRA1GeneProductENSG00000110497 (Ensembl)
ATG101GeneProductENSG00000123395 (Ensembl)
ATG12GeneProductENSG00000145782 (Ensembl)
ATG13GeneProductENSG00000175224 (Ensembl)
ATG14GeneProductENSG00000126775 (Ensembl)
ATG16L1GeneProductENSG00000085978 (Ensembl)
ATG3GeneProductENSG00000144848 (Ensembl)
ATG5GeneProductENSG00000057663 (Ensembl)
ATG7GeneProductENSG00000197548 (Ensembl)
ATG9AGeneProductENSG00000198925 (Ensembl)
BECN1GeneProductENSG00000126581 (Ensembl)
DEPTORGeneProductENSG00000155792 (Ensembl)
MAP1LC3BGeneProductENSG00000140941 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
PEMetaboliteCHEBI:16038 (ChEBI)
PIK3C3GeneProductENSG00000078142 (Ensembl)
PIK3R4GeneProductENSG00000196455 (Ensembl)
PRKAA1GeneProductENSG00000132356 (Ensembl)
PRKAA2GeneProductENSG00000162409 (Ensembl)
PRKAB1GeneProductENSG00000111725 (Ensembl)
PRKAB2GeneProductENSG00000131791 (Ensembl)
PRKAG1GeneProductENSG00000181929 (Ensembl)
PRKAG2GeneProductENSG00000106617 (Ensembl)
PRKAG3GeneProductENSG00000115592 (Ensembl)
PtdIns3PMetaboliteCHEBI:17283 (ChEBI)
RB1CC1GeneProductENSG00000023287 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
ULK1GeneProductENSG00000177169 (Ensembl)
UVRAGGeneProductENSG00000198382 (Ensembl)
WIPI2GeneProductENSG00000157954 (Ensembl)

Annotated Interactions

No annotated interactions

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