Mitochondrial CIV Assembly (Homo sapiens)

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1MT-CO2 moduleComplex IVCMC1SCO2COX19COX6A1PET100NDUFA4COX20COX18COX15TACO1COX7BPNKDMT-CO1COX6CHeme ASURF1COX11CopperSMIM20COX8ACOX6B1PET117TMEM177MT-CO2COX5BCOX16COX7A2HIGD1ACOA6COA3COX5ACOX14COX10COX17Heme OMT-CO3Heme BCOX4I1COX7CTACO1CMC1COA3COX14MT-CO1TACO1CMC1COA3COX14MT-CO1TACO1CMC1CopperCOX17COX18MT-CO2COX20COX16COA6SCO2TMEM177MT-CO2COX20COX6CCOX5BCOX7BCOX8ACOX7CSURF1SMIM20CMC1COA3COX14MT-CO1TACO1COX16COA6SCO2TMEM177MT-CO2COX20COX6CCOX5BCOX7BCOX8ACOX7CPET100PET117PNKDMT-CO1 module'MITRAC'MT-CO3 moduleSURF1SMIM20CMC1COA3COX14MT-CO1TACO1COX16COA6SCO2TMEM177MT-CO2COX20COX6CCOX5BCOX7BCOX8ACOX7CPET100PET117PNKDCOX6B1COX7A2COX6A1MT-CO3SURF1SMIM20CMC1COA3COX14MT-CO1TACO1COX16COA6SCO2TMEM177MT-CO2COX20COX6CCOX5BCOX7BCOX8ACOX7CPET100PET117PNKDCOX6B1COX7A2COX6A1MT-CO3NDUFA4


Description

Complex IV or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation. Mammalian cIV contains 13 subunits. MT-CO1 is the largest catalytic subunit. MT-CO2 is the second core subunit. MT-CO3, the third core subunit has no direct catalytic role. The supernumerary subunits do not seem to have a catalytic role, but are thought to be important for the stabilization and regulation of the catalytic core. Complex IV is the only OXPHOS complex containing tissue-specific and developmentally regulated isoforms.

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Ontology Terms

 

Bibliography

  1. Signes A, Fernandez-Vizarra E; ''''; , PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
110390view16:17, 8 May 2020AnnabayaModified description
110389view16:10, 8 May 2020AnnabayaFix interactions
110374view15:24, 8 May 2020AnnabayaOntology Term : 'electron transport chain pathway' added !
110373view15:23, 8 May 2020AnnabayaOntology Term : 'oxidative phosphorylation pathway' added !
110357view16:28, 7 May 2020Marvin M2Removed genes that shouldn't be there
110356view16:08, 7 May 2020AnnabayaNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CMC1GeneProductENSG00000187118 (Ensembl)
COA3GeneProductENSG00000183978 (Ensembl)
COA6GeneProductENSG00000168275 (Ensembl)
COX10GeneProductENSG00000006695 (Ensembl)
COX11GeneProductENSG00000166260 (Ensembl)
COX14GeneProductENSG00000178449 (Ensembl)
COX15GeneProductENSG00000014919 (Ensembl)
COX16GeneProductENSG00000133983 (Ensembl)
COX17GeneProductENSG00000138495 (Ensembl)
COX18GeneProductENSG00000163626 (Ensembl)
COX19GeneProductENSG00000240230 (Ensembl)
COX20GeneProductENSG00000203667 (Ensembl)
COX4I1GeneProductENSG00000131143 (Ensembl)
COX5AGeneProductENSG00000178741 (Ensembl)
COX5BGeneProductENSG00000135940 (Ensembl)
COX6A1GeneProductENSG00000111775 (Ensembl)
COX6B1GeneProductENSG00000126267 (Ensembl)
COX6CGeneProductENSG00000164919 (Ensembl)
COX7A2GeneProductENSG00000112695 (Ensembl)
COX7BGeneProductENSG00000131174 (Ensembl)
COX7CGeneProductENSG00000127184 (Ensembl)
COX8AGeneProductENSG00000176340 (Ensembl)
CopperMetaboliteCHEBI:30052 (ChEBI)
HIGD1AGeneProductENSG00000181061 (Ensembl)
Heme AMetaboliteCHEBI:24479 (ChEBI)
Heme BMetaboliteCHEBI:26355 (ChEBI)
Heme OMetaboliteCHEBI:24480 (ChEBI)
MT-CO1GeneProductENSG00000198804 (Ensembl)
MT-CO2GeneProductENSG00000198712 (Ensembl)
MT-CO3GeneProductENSG00000198938 (Ensembl)
NDUFA4GeneProductENSG00000189043 (Ensembl)
PET100GeneProductENSG00000229833 (Ensembl)
PET117GeneProductENSG00000232838 (Ensembl)
PNKDGeneProductENSG00000127838 (Ensembl)
SCO2GeneProductENSG00000130489 (Ensembl)
SMIM20GeneProductENSG00000250317 (Ensembl)
SURF1GeneProductENSG00000148290 (Ensembl)
TACO1GeneProductENSG00000136463 (Ensembl)
TMEM177GeneProductENSG00000144120 (Ensembl)

Annotated Interactions

No annotated interactions

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