Neuroinflammation (Homo sapiens)

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1Oxidative Stress, Inflammatory Cytokines, UVCytokinesNF-κBProteolysis and IkB DegradationUbiquination and PhosphorylationProteinsAP-1ROSFOSiNOSNitrate reductaseNitriteAKTNitratePI3KNADPHCa2+p65MAPK14CalmodulinH2OIKKαTNF-αIL-1BNADP+COX1JNKMTORJUNp50NOL-arginineL-citrullineCOX2TLR4IκBαO2NADPH2NADP+O2JUNp50p65p50p65IκBαIκBαp50p65p50p653


Description

Neuroinflammation is inflammation specific to parts of the central nervous system. It can be triggered by external or internal factors, such as UV damage, inflammatory cytokines and oxidative stress. Stress on the cell leads to activation of inflammatory response pathways that involve several transcription factors such as AP-1 and NFkB, which will lead to the transcription of several proteins and/or cytokines.

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Ontology Terms

 

Bibliography

  1. Shabab T, Khanabdali R, Moghadamtousi SZ, Kadir HA, Mohan G; ''Neuroinflammation pathways: a general review.''; Int J Neurosci, 2017 PubMed Europe PMC Scholia
  2. Xing B, Bachstetter AD, Van Eldik LJ; ''Inhibition of neuronal p38α, but not p38β MAPK, provides neuroprotection against three different neurotoxic insults.''; J Mol Neurosci, 2015 PubMed Europe PMC Scholia
  3. Liu T, Zhang L, Joo D, Sun SC; ''NF-κB signaling in inflammation.''; Signal Transduct Target Ther, 2017 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
111814view19:06, 8 September 2020EgonwCorrected the format of the BRENDA identifier.
110412view10:17, 9 May 2020EgonwReplaced secondary ChEBI identifiers with a primary identifiers.
110407view03:27, 9 May 2020Marvin M2Ontology Term : 'stress response pathway' added !
110386view15:59, 8 May 2020AnnabayaModified description
110382view15:35, 8 May 2020AnnabayaOntology Term : 'regulatory pathway pertinent to the brain' added !
110380view15:33, 8 May 2020AnnabayaOntology Term : 'PW:0000754' removed !
110379view15:33, 8 May 2020AnnabayaOntology Term : 'drug pathway' added !
110369view15:15, 8 May 2020AnnabayaEdit NFkB interactions
110366view12:19, 8 May 2020AnnabayaEdit interactions and fix gene IDs
110353view13:39, 7 May 2020AnnabayaNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKTGeneProduct391 (HGNC)
COX1GeneProductENSG00000198804 (Ensembl)
COX2GeneProductENSG00000198712 (Ensembl)
Ca2+MetaboliteCHEBI:3308 (ChEBI)
CalmodulinMetaboliteCHEBI:3324 (ChEBI)
FOSGeneProductENSG00000170345 (Ensembl)
H2OMetaboliteCHEBI:15377 (ChEBI)
IKKαGeneProductENSG00000213341 (Ensembl)
IL-1BGeneProduct481 (HomoloGene)
IκBαGeneProductENSG00000100906 (Ensembl)
JNKGeneProductENSG00000107643 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
L-arginineMetaboliteCHEBI:16467 (ChEBI)
L-citrullineMetaboliteCHEBI:57743 (ChEBI)
MAPK14GeneProductENSG00000112062 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
NADP+MetaboliteCHEBI:7424 (ChEBI)
NADPHMetaboliteCHEBI:7425 (ChEBI)
NOMetaboliteCHEBI:16480 (ChEBI)
Nitrate reductaseGeneProductBRENDA:EC1.7.99.4 (BRENDA)
NitrateMetaboliteCHEBI:7580 (ChEBI)
NitriteMetaboliteCHEBI:7585 (ChEBI)
O2MetaboliteCHEBI:15379 (ChEBI)
PI3KGeneProductIPR000403 (InterPro)
ROSPathwayWP3941 (WikiPathways)
TLR4GeneProductENSG00000136869 (Ensembl)
TNF-αGeneProduct496 (HomoloGene)
iNOSGeneProductENSG00000007171 (Ensembl)
p50GeneProductENSG00000138303 (Ensembl)
p65GeneProductENSG00000173039 (Ensembl)

Annotated Interactions

No annotated interactions

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