Neuroinflammation (Homo sapiens)

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1Inflammatory Gene ExpressionTranscriptionUbiquination and PhosphorylationProteinsTranslationOxidative Stress, Inflammatory Cytokines, UVCytokinesInflammatory Response GenesProteolysis and IkB DegradationAP-1MTORCOX1L-arginineNOCOX2IκBαp65AKTH2OJNKO2iNOSTLR4NADPHC-JUNCalmodulinp50NADP+Nitrate reductasePI3KTNF-αP38/MAPKIKKαL-citrullineCa2+NitriteNitrateIL-1B[NFκB][SAPK]NADPHNADP+O2JNKC-JUNp50p65p50p65IκBαIκBα


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Ontology Terms



  1. Shabab T, Khanabdali R, Moghadamtousi SZ, Kadir HA, Mohan G; ''Neuroinflammation pathways: a general review.''; Int J Neurosci, 2017 PubMed Europe PMC Scholia
  2. Xing B, Bachstetter AD, Van Eldik LJ; ''Inhibition of neuronal p38α, but not p38β MAPK, provides neuroprotection against three different neurotoxic insults.''; J Mol Neurosci, 2015 PubMed Europe PMC Scholia
  3. Liu T, Zhang L, Joo D, Sun SC; ''NF-κB signaling in inflammation.''; Signal Transduct Target Ther, 2017 PubMed Europe PMC Scholia


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110412view10:17, 9 May 2020EgonwReplaced secondary ChEBI identifiers with a primary identifiers.
110407view03:27, 9 May 2020Marvin M2Ontology Term : 'stress response pathway' added !
110386view15:59, 8 May 2020AnnabayaModified description
110382view15:35, 8 May 2020AnnabayaOntology Term : 'regulatory pathway pertinent to the brain' added !
110380view15:33, 8 May 2020AnnabayaOntology Term : 'PW:0000754' removed !
110379view15:33, 8 May 2020AnnabayaOntology Term : 'drug pathway' added !
110369view15:15, 8 May 2020AnnabayaEdit NFkB interactions
110366view12:19, 8 May 2020AnnabayaEdit interactions and fix gene IDs
110353view13:39, 7 May 2020AnnabayaNew pathway

External references


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NameTypeDatabase referenceComment
AKTGeneProduct391 (HGNC)
AP-1GeneProductIPR002112 (InterPro)
C-JUNGeneProduct1679 (HomoloGene)
COX1GeneProductENSG00000198804 (Ensembl)
COX2GeneProductENSG00000198712 (Ensembl)
Ca2+MetaboliteCHEBI:3308 (ChEBI)
CalmodulinMetaboliteCHEBI:3324 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
IKKαGeneProductENSG00000213341 (Ensembl)
IL-1BGeneProduct481 (HomoloGene)
IκBαGeneProduct7863 (HomoloGene)
JNKGeneProduct6881 (HGNC)
L-arginineMetaboliteCHEBI:16467 (ChEBI)
L-citrullineMetaboliteCHEBI:57743 (ChEBI)
MTORGeneProductENSG00000198793 (Ensembl)
NADP+MetaboliteCHEBI:7424 (ChEBI)
NADPHMetaboliteCHEBI:7425 (ChEBI)
NOMetaboliteCHEBI:16480 (ChEBI)
Nitrate reductaseGeneProductBRENDA:EC1.7.99.4 (BRENDA)
NitrateMetaboliteCHEBI:7580 (ChEBI)
NitriteMetaboliteCHEBI:7585 (ChEBI)
O2MetaboliteCHEBI:15379 (ChEBI)
P38/MAPKGeneProduct6873 (HGNC)
PI3KGeneProductIPR000403 (InterPro)
TLR4GeneProductENSG00000136869 (Ensembl)
TNF-αGeneProduct496 (HomoloGene)
iNOSGeneProductENSG00000007171 (Ensembl)
p50GeneProductENSG00000138303 (Ensembl)
p65GeneProduct32064 (HomoloGene)

Annotated Interactions

No annotated interactions

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