Cellular Proteostasis (Homo sapiens)

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12Native proteinStress signalingPrefoldinStressFolding intermediateHSRAggresomeAggregatesMisfolded stateStress responseProtein synthesisPFDN2PFDN6PFDN1UPRPFDN5CHIPDegredation via AutophagyHsp110Hsp40Hsp90PFDN4PFDN3Degredation via UPSHsp70MutationsStressMutationsHsp40Hsp70Hsp40Hsp70Hsp110Hsp40Hsp70Hsp90Hsp70Hsp70Hsp90CHIP


In order to maintain protein homeostasis and cell function, cells are constantly synthesizing as well as degrading proteins. This is especially important when proteins are misfolded, due to extra- or intracellular stress or a genetic mutation, as this is the basis for many diseases. This pathway shows the major events which are involved in proteostasis.

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Ontology Terms



  1. Klaips CL, Jayaraj GG, Hartl FU; ''Pathways of cellular proteostasis in aging and disease.''; J Cell Biol, 2018 PubMed Europe PMC Scholia
  2. Sahlan M, Zako T, Yohda M; ''Prefoldin, a jellyfish-like molecular chaperone: functional cooperation with a group II chaperonin and beyond.''; Biophys Rev, 2018 PubMed Europe PMC Scholia


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110411view08:51, 9 May 2020AnnabayaAdd pathway reference
110406view03:19, 9 May 2020Marvin M2Ontology Term : 'translation pathway' added !
110383view15:43, 8 May 2020AnnabayaModified description
110377view15:25, 8 May 2020AnnabayaOntology Term : 'protein folding pathway' added !
110367view12:39, 8 May 2020AnnabayaEdit interaction, added pathway link and prefoldin complex
110352view13:38, 7 May 2020AnnabayaNew pathway

External references


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NameTypeDatabase referenceComment
CHIPGeneProductENST00000565813.1 (Ensembl)
Degredation via AutophagyPathwayWP4923 (WikiPathways)
Degredation via UPSPathwayWP183 (WikiPathways)
Hsp110GeneProductENST00000629751 (Ensembl)
Hsp40GeneProductENSG00000213946 (Ensembl)
Hsp70GeneProductENSG00000225217 (Ensembl)
Hsp90GeneProductENSG00000224411 (Ensembl)
PFDN1GeneProductENSG00000113068 (Ensembl)
PFDN2GeneProductENSG00000143256 (Ensembl)
PFDN3GeneProductENSG00000155959 (Ensembl)
PFDN4GeneProductENSG00000101132 (Ensembl)
PFDN5GeneProductENSG00000123349 (Ensembl)
PFDN6GeneProductENSG00000204220 (Ensembl)
UPRPathwayWP1939 (WikiPathways)

Annotated Interactions

No annotated interactions

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