Cellular Proteostasis (Homo sapiens)

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12PrefoldinMisfolded stateStress responseHSRAggresomeAggregatesStress signalingNative proteinStressProtein synthesisDegredation via UPSFolding intermediateDegredation via AutophagyPFDN4PFDN3PFDN5CHIPPFDN6PFDN2UPRHsp70Hsp110Hsp90Hsp40PFDN1MutationsStressMutationsHsp40Hsp70Hsp40Hsp70Hsp110Hsp40Hsp70Hsp90Hsp70Hsp70Hsp90CHIP


No description

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Ontology Terms



  1. Klaips CL, Jayaraj GG, Hartl FU; ''Pathways of cellular proteostasis in aging and disease.''; J Cell Biol, 2018 PubMed Europe PMC Scholia
  2. Sahlan M, Zako T, Yohda M; ''Prefoldin, a jellyfish-like molecular chaperone: functional cooperation with a group II chaperonin and beyond.''; Biophys Rev, 2018 PubMed Europe PMC Scholia


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110411view08:51, 9 May 2020AnnabayaAdd pathway reference
110406view03:19, 9 May 2020Marvin M2Ontology Term : 'translation pathway' added !
110383view15:43, 8 May 2020AnnabayaModified description
110377view15:25, 8 May 2020AnnabayaOntology Term : 'protein folding pathway' added !
110367view12:39, 8 May 2020AnnabayaEdit interaction, added pathway link and prefoldin complex
110352view13:38, 7 May 2020AnnabayaNew pathway

External references


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NameTypeDatabase referenceComment
CHIPGeneProductENST00000565813.1 (Ensembl)
Degredation via AutophagyPathwayWP4923 (WikiPathways)
Hsp110GeneProductENST00000629751 (Ensembl)
Hsp40GeneProductENSG00000213946 (Ensembl)
Hsp70GeneProductENSG00000225217 (Ensembl)
Hsp90GeneProductENSG00000224411 (Ensembl)
PFDN1GeneProductENSG00000113068 (Ensembl)
PFDN2GeneProductENSG00000143256 (Ensembl)
PFDN3GeneProductENSG00000155959 (Ensembl)
PFDN4GeneProductENSG00000101132 (Ensembl)
PFDN5GeneProductENSG00000123349 (Ensembl)
PFDN6GeneProductENSG00000204220 (Ensembl)
UPRPathwayWP1939 (WikiPathways)

Annotated Interactions

No annotated interactions

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