Proximal tubule transport (Homo sapiens)

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23V-type H+-ATPaseNHE3Amino acid transportApical side6, 9Basolateral side7SLC16A10SLC5A2GlyATP6V1FATP6V1AAlaATP6V1C1SLC9A3ATP6V1B1SLC7A9CysSLC6A19LactateATP6V0BTMEM27SLC2A2ATP1A1ATP6V1DCA4SLC7A8SLC3A1ATP6V1E1SLC5A8FXYD2ATP6V0D2AA+AA-ATP6V0E1SLC7A7SLC4A2SLC1A1ATP6V0CATP1B1I-HCO3-ATP6V1HSLC5A5ATP6V0A4SLC6A18SLC4A4SLC6A20Na+ATP6V1G1SLC36A2ProAQP1SLC3A25484K+1Na+K+Na+Na+Na+Na+H+H+Cl-HCO3-HCO3-Cl-H+H+H2CO3H2OCO2H+CA25H2OCO2HCO3-H+Na+Na+HCO3-AQP1H2OCO2Na+Na+GlucoseGlucoseGlucoseGlucoseI-Na+Na+Na+Na+LactateSLC3A2TMEM27TMEM27H+H+Na+Na+Na+K+ProAA0AA0AA0AA0AA0AA+AA+AA0Na+AA-H+Na+K+ProGlyAlaH+Na+ProNa+Na+AA0AA0Na+Na+AA0AA0CysAA+AA0AA0


Description

New pathway on proximal tubule transport

Quality Tags

Ontology Terms

 

Bibliography

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  1. Verrey F, Singer D, Ramadan T, Vuille-dit-Bille RN, Mariotta L, Camargo SM; ''Kidney amino acid transport.''; Pflugers Arch, 2009 PubMed Europe PMC Scholia
  2. Koeppen, B. M., Stanton, B. A.; ''Renal physiology (6th ed., Ser. Mosby physiology series)''; Elsevier, 2019
  3. Curthoys NP, Moe OW; ''Proximal tubule function and response to acidosis.''; Clin J Am Soc Nephrol, 2014 PubMed Europe PMC Scholia
  4. Portulano C, Paroder-Belenitsky M, Carrasco N; ''The Na+/I- symporter (NIS): mechanism and medical impact.''; Endocr Rev, 2014 PubMed Europe PMC Scholia
  5. Purkerson JM, Schwartz GJ; ''The role of carbonic anhydrases in renal physiology.''; Kidney Int, 2007 PubMed Europe PMC Scholia
  6. Gopal E, Fei YJ, Sugawara M, Miyauchi S, Zhuang L, Martin P, Smith SB, Prasad PD, Ganapathy V; ''Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  7. Aronson PS; ''Essential roles of CFEX-mediated Cl(-)-oxalate exchange in proximal tubule NaCl transport and prevention of urolithiasis.''; Kidney Int, 2006 PubMed Europe PMC Scholia
  8. Clausen MV, Hilbers F, Poulsen H; ''The Structure and Function of the Na,K-ATPase Isoforms in Health and Disease.''; Front Physiol, 2017 PubMed Europe PMC Scholia
  9. Sarkar J, Wen X, Simanian EJ, Paine ML; ''V-type ATPase proton pump expression during enamel formation.''; Matrix Biol, 2016 PubMed Europe PMC Scholia
  10. Liapis H, Nag M, Kaji DM; ''K-Cl cotransporter expression in the human kidney.''; Am J Physiol, 1998 PubMed Europe PMC Scholia
  11. Skelton LA, Boron WF, Zhou Y; ''Acid-base transport by the renal proximal tubule.''; J Nephrol, 2010 PubMed Europe PMC Scholia
  12. Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP; ''Renal vacuolar H+-ATPase.''; Physiol Rev, 2004 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
110974view14:01, 25 June 2020Fehrhartchanged MIM conversion to graphical line
110418view14:46, 9 May 2020Marvin M2Modified description
110417view14:42, 9 May 2020Marvin M2Connected unconnected lines
110405view03:02, 9 May 2020Marvin M2Modified description
110404view03:02, 9 May 2020Marvin M2Ontology Term : 'Fanconi syndrome' added !
110403view02:56, 9 May 2020Marvin M2Ontology Term : 'transport pathway' added !
110402view02:52, 9 May 2020Marvin M2Ontology Term : 'epithelial cell of proximal tubule' added !
110401view02:41, 9 May 2020Marvin M2Modified description
110400view02:28, 9 May 2020Marvin M2completed pathway figure
110368view15:13, 8 May 2020AnnabayaAdd amino acid transport and V-type H+-ATPase
110339view02:12, 7 May 2020Marvin M2New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AA+MetaboliteCHEBI:58942 (ChEBI)
AA-MetaboliteCHEBI:64898 (ChEBI)
AQP1GeneProductENSG00000240583 (Ensembl)
ATP1A1GeneProductENSG00000163399 (Ensembl)
ATP1B1GeneProductENSG00000143153 (Ensembl)
ATP6V0A4GeneProductENSG00000105929 (Ensembl)
ATP6V0BGeneProductENSG00000117410 (Ensembl)
ATP6V0CGeneProductENSG00000185883 (Ensembl)
ATP6V0D2GeneProductENSG00000147614 (Ensembl)
ATP6V0E1GeneProductENSG00000113732 (Ensembl)
ATP6V1AGeneProductENSG00000114573 (Ensembl)
ATP6V1B1GeneProductENSG00000116039 (Ensembl)
ATP6V1C1GeneProductENSG00000155097 (Ensembl)
ATP6V1DGeneProductENSG00000100554 (Ensembl)
ATP6V1E1GeneProductENSG00000131100 (Ensembl)
ATP6V1FGeneProductENSG00000128524 (Ensembl)
ATP6V1G1GeneProductENSG00000136888 (Ensembl)
ATP6V1HGeneProductENSG00000047249 (Ensembl)
AlaMetabolite16449 (ChEBI)
CA2GeneProductENSG00000104267 (Ensembl)
CA4GeneProductENSG00000167434 (Ensembl)
CO2Metabolite
Cl-Metabolite
CysMetabolite17376 (ChEBI)
FXYD2GeneProductENSG00000137731 (Ensembl)
GlucoseMetabolite
GlyMetabolite15428 (ChEBI)
H+Metabolite
H2CO3Metabolite
H2OMetabolite
HCO3-Metabolite
I-Metabolite
K+Metabolite
LactateMetabolite
Na+Metabolite
ProMetabolite26271 (ChEBI)
SLC16A10GeneProductENSG00000112394 (Ensembl)
SLC1A1GeneProductENSG00000106688 (Ensembl)
SLC2A2GeneProductENSG00000163581 (Ensembl)
SLC36A2GeneProductENSG00000186335 (Ensembl)
SLC3A1GeneProductENSG00000138079 (Ensembl)
SLC3A2GeneProductENSG00000168003 (Ensembl)
SLC4A2GeneProductENSG00000164889 (Ensembl)
SLC4A4GeneProductENSG00000080493 (Ensembl)
SLC5A2GeneProductENSG00000140675 (Ensembl)
SLC5A5GeneProductENSG00000105641 (Ensembl)
SLC5A8GeneProductENSG00000256870 (Ensembl)
SLC6A18GeneProductENSG00000164363 (Ensembl)
SLC6A19GeneProductENSG00000174358 (Ensembl)
SLC6A20GeneProductENSG00000163817 (Ensembl)
SLC7A7GeneProductENSG00000155465 (Ensembl)
SLC7A8GeneProductENSG00000092068 (Ensembl)
SLC7A9GeneProductENSG00000021488 (Ensembl)
SLC9A3GeneProductENSG00000066230 (Ensembl)
TMEM27GeneProductENSG00000147003 (Ensembl)

Annotated Interactions

No annotated interactions

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