Proximal tubule transport (Homo sapiens)

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12V-type H+-ATPaseAmino acid transportNHE3Apical side46Basolateral sideNa+SLC4A2AQP1FXYD2ATP1A1SLC4A4SLC9A3SLC5A5HCO3-SLC5A2I-LactateATP1B1SLC5A8CA4SLC2A2K+75833Na+K+Na+Na+Na+Na+H+H+Cl-HCO3-HCO3-Cl-H+H+H2CO3H2OCO2H+CA25H2OCO2HCO3-H+Na+Na+HCO3-AQP1H2OCO2Na+Na+GlucoseGlucoseGlucoseGlucoseI-Na+Na+Na+Na+Lactate


New pathway on proximal tubule transport

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  1. Verrey F, Singer D, Ramadan T, Vuille-dit-Bille RN, Mariotta L, Camargo SM; ''Kidney amino acid transport.''; Pflugers Arch, 2009 PubMed Europe PMC Scholia
  2. Koeppen, B. M., Stanton, B. A.; ''Renal physiology (6th ed., Ser. Mosby physiology series)''; Elsevier, 2019
  3. Curthoys NP, Moe OW; ''Proximal tubule function and response to acidosis.''; Clin J Am Soc Nephrol, 2014 PubMed Europe PMC Scholia
  4. Portulano C, Paroder-Belenitsky M, Carrasco N; ''The Na+/I- symporter (NIS): mechanism and medical impact.''; Endocr Rev, 2014 PubMed Europe PMC Scholia
  5. Purkerson JM, Schwartz GJ; ''The role of carbonic anhydrases in renal physiology.''; Kidney Int, 2007 PubMed Europe PMC Scholia
  6. Gopal E, Fei YJ, Sugawara M, Miyauchi S, Zhuang L, Martin P, Smith SB, Prasad PD, Ganapathy V; ''Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  7. Aronson PS; ''Essential roles of CFEX-mediated Cl(-)-oxalate exchange in proximal tubule NaCl transport and prevention of urolithiasis.''; Kidney Int, 2006 PubMed Europe PMC Scholia
  8. Clausen MV, Hilbers F, Poulsen H; ''The Structure and Function of the Na,K-ATPase Isoforms in Health and Disease.''; Front Physiol, 2017 PubMed Europe PMC Scholia
  9. Sarkar J, Wen X, Simanian EJ, Paine ML; ''V-type ATPase proton pump expression during enamel formation.''; Matrix Biol, 2016 PubMed Europe PMC Scholia
  10. Liapis H, Nag M, Kaji DM; ''K-Cl cotransporter expression in the human kidney.''; Am J Physiol, 1998 PubMed Europe PMC Scholia
  11. Skelton LA, Boron WF, Zhou Y; ''Acid-base transport by the renal proximal tubule.''; J Nephrol, 2010 PubMed Europe PMC Scholia
  12. Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP; ''Renal vacuolar H+-ATPase.''; Physiol Rev, 2004 PubMed Europe PMC Scholia


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110974view14:01, 25 June 2020Fehrhartchanged MIM conversion to graphical line
110418view14:46, 9 May 2020Marvin M2Modified description
110417view14:42, 9 May 2020Marvin M2Connected unconnected lines
110405view03:02, 9 May 2020Marvin M2Modified description
110404view03:02, 9 May 2020Marvin M2Ontology Term : 'Fanconi syndrome' added !
110403view02:56, 9 May 2020Marvin M2Ontology Term : 'transport pathway' added !
110402view02:52, 9 May 2020Marvin M2Ontology Term : 'epithelial cell of proximal tubule' added !
110401view02:41, 9 May 2020Marvin M2Modified description
110400view02:28, 9 May 2020Marvin M2completed pathway figure
110368view15:13, 8 May 2020AnnabayaAdd amino acid transport and V-type H+-ATPase
110339view02:12, 7 May 2020Marvin M2New pathway

External references


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NameTypeDatabase referenceComment
AQP1GeneProductENSG00000240583 (Ensembl)
ATP1A1GeneProductENSG00000163399 (Ensembl)
ATP1B1GeneProductENSG00000143153 (Ensembl)
CA2GeneProductENSG00000104267 (Ensembl)
CA4GeneProductENSG00000167434 (Ensembl)
FXYD2GeneProductENSG00000137731 (Ensembl)
SLC2A2GeneProductENSG00000163581 (Ensembl)
SLC4A2GeneProductENSG00000164889 (Ensembl)
SLC4A4GeneProductENSG00000080493 (Ensembl)
SLC5A2GeneProductENSG00000140675 (Ensembl)
SLC5A5GeneProductENSG00000105641 (Ensembl)
SLC5A8GeneProductENSG00000256870 (Ensembl)
SLC9A3GeneProductENSG00000066230 (Ensembl)

Annotated Interactions

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