SARS coronavirus and innate immunity (Homo sapiens)

From WikiPathways

Revision as of 15:24, 29 April 2020 by Fehrhart (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
1SISRE Response elementNucleusEndocytosisphosphorylized proteinCellDNAIFN-alpha groupIFNA13IKBKEIRF9STAT1TRAF3TLR3IFNA6TYK2ACE2STAT2SIFNA17IFNAR1IFNA2IFNA5IFNB1IFIH1IFNA14JAK1IFNA8DDX58IFNA7TBK1IFNA16IRF3IFNA21IFNA1IFNAR2IFNA10TICAM1IFNA4MAVSIFN-betaIRF3IRF3IRF3ACE2SSSARS virus protein (Spike)STAT1STAT2IRF9IFN-betaResponse elementMitochondriaVesicle


Description

SARS-CoV triggers the hosts innate immune system via the type I interferon system in dendritic cells and macrophages, which activate ISRE and IFN-b sentitive promoter elements.

Quality Tags

Ontology Terms

 

Bibliography

  1. Frieman M, Heise M, Baric R; ''SARS coronavirus and innate immunity.''; Virus Res, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
110359view17:32, 7 May 2020Fehrhartgraphical improvements
110248view06:52, 30 April 2020FehrhartOntology Term : 'severe acute respiratory syndrome' added !
110247view06:52, 30 April 2020FehrhartOntology Term : 'viral infectious disease' added !
110246view06:52, 30 April 2020FehrhartOntology Term : 'type I interferon signaling pathway' added !
110239view15:24, 29 April 2020FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACE2GeneProductENSG00000130234 (Ensembl)
DDX58GeneProductENSG00000107201 (Ensembl) RIG-I
IFIH1GeneProductENSG00000115267 (Ensembl) MDA5
IFNA10GeneProductENSG00000186803 (Ensembl)
IFNA13GeneProductENSG00000233816 (Ensembl)
IFNA14GeneProductENSG00000228083 (Ensembl)
IFNA16GeneProductENSG00000147885 (Ensembl)
IFNA17GeneProductENSG00000234829 (Ensembl)
IFNA1GeneProductENSG00000197919 (Ensembl)
IFNA21GeneProductENSG00000137080 (Ensembl)
IFNA2GeneProductENSG00000188379 (Ensembl)
IFNA4GeneProductENSG00000236637 (Ensembl)
IFNA5GeneProductENSG00000147873 (Ensembl)
IFNA6GeneProductENSG00000120235 (Ensembl)
IFNA7GeneProductENSG00000214042 (Ensembl)
IFNA8GeneProductENSG00000120242 (Ensembl)
IFNAR1GeneProduct3454 (Entrez Gene)
IFNAR2GeneProduct3455 (Entrez Gene)
IFNB1GeneProductENSG00000171855 (Ensembl)
IKBKEGeneProductENSG00000263528 (Ensembl) IKK-e
IRF3GeneProductENSG00000126456 (Ensembl)
IRF9GeneProductENSG00000213928 (Ensembl)
JAK1GeneProductENSG00000162434 (Ensembl)
MAVSGeneProductENSG00000088888 (Ensembl)
SGeneProduct694009 (Uniprot-TrEMBL)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT2GeneProductENSG00000170581 (Ensembl)
TBK1GeneProductENSG00000183735 (Ensembl)
TICAM1GeneProduct148022 (Entrez Gene) TRIF
TLR3GeneProductENSG00000164342 (Ensembl)
TRAF3GeneProductENSG00000131323 (Ensembl)
TYK2GeneProductENSG00000105397 (Ensembl)

Annotated Interactions

No annotated interactions

Personal tools