IL-2 Signaling Pathway (Homo sapiens)

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DephosphorylationReactions through unknown mechanisms/moleculesPMDNucleusGolgi apparatusMTCY -> NUMethylationPlasma membraneNUEndosome(Protein-protein interaction)AcetylationDPalmitolyationMitochondrionSumoylationDPM -> CYDCY -> NUPhosphorylationNUDCY -> PMDesumoylationGOUbiquitinationNucleusControlMolecule in the pathwayCYENAutophosphorylationDERDDGene SymbolCY -> NUECDCY -> NURecruitmentDemethylationMolecular associationCY -> NUDReceptorInhibitionActivationCY -> NUEnzyme complexAccession Number: NetPath 14LigandProteolytic cleavageDPhosphorylationMTCY -> NUDeubiquitinationCY -> NUEndoplasmic reticulumTranslocationCytoplasmExtracellularGlycosylationDDeacetylationProteins in a complex interactionVAV1JAK1CRKLSTAT5BNSEP1EIF4EMAPK3MAPK8NFKB1MAPK1IL2LYNAKT1MAPK3JAK3PIK3R1GNB2L1SOS1RELAICAM1HSPCAMAP2K2FOXO3AMAP2K1PIK3R2IL2MAPKAPK2MAPK1ETS1PTPN6STAT1TERTCRKPIK3CALCKPTK2BEIF3S9MAPK9NR3C1NSEP1SOCS1STAT5ARPS6KB1CRKTERTNMICISHIL2RGNFKB1RAF1JAK2ETS2AKT1CHUKRAF1SHBGAB2PIK3CDFRAP1AKT1BCL2RELAIFNA1SOCS3IL2RAPTPN11STAM2IL2IL2GRB2FYNMAPK14ITM2BPIK3CGSTAT5BIL2SYKPRKCZMKNK1SHC1IL2RBPIK3CBIRS2PLCB1STAMSTAT5AKRASCD53CBLSTAT3CREB1IRS1


Interleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 receptor beta (CD122) and a common gamma chain (γc), which is shared by all members of this family of cytokines. Binding of IL-2 activates the Ras/MAPK, JAK/Stat and PI 3-kinase/Akt signaling modules. Source: NetPath


GenMAPP notes 
NetPath 14 - IL-2 Signaling Pathway

NetPath ( is a collaborative project between PandeyLab at Johns Hopkins University ( and the Institute of Bioinformatics ( If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks

Quality Tags

Ontology Terms



  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia


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115909view12:12, 20 March 2021EgonwCopied the NetPath paper into the literature list
115908view11:13, 20 March 2021EgonwModified description
95132view16:25, 16 November 2017Fehrhartconnecting unconnected connections
95131view16:19, 16 November 2017Fehrhartconnecting unconnected connections
91243view20:37, 21 January 2017AlexanderPicoconnected a few interactions
89826view12:04, 6 October 2016MkutmonModified description
78543view10:30, 7 January 2015MaintBotadded missing graphIds
75383view21:22, 21 May 2014KhanspersRemoved GenMAPP notes/comments
72047view16:52, 24 October 2013Mkutmonupdated annotations
70015view01:49, 12 July 2013AlexanderPicoModified title
67369view10:43, 26 June 2013Christine ChichesterOntology Term : 'interleukin-2 signaling pathway' added !
63209view20:57, 8 May 2013MaintBotUpdating gpml version
59182view18:45, 22 February 2013MaintBotUpdated Ensembl data source
48400view07:35, 24 May 2012NetPathModified description
48399view07:30, 24 May 2012NetPathModified description
46125view21:34, 18 December 2011AlexanderPicofixed entrez references
45366view20:58, 7 October 2011AlexanderPicoOntology Term : 'DOID:8406' removed !
45130view00:47, 7 October 2011AlexanderPicofixed db ref
44843view09:45, 6 October 2011MartijnVanIerselOntology Term : 'Interleukin mediated signaling pathway' added !
44833view07:58, 6 October 2011Mkutmonconnected some lines
44622view17:54, 22 September 2011KhanspersUpdating content to NetSlim
44106view20:29, 24 August 2011KhanspersReverted to version '23:39, 1 March 2011' by Khanspers
44029view23:05, 22 August 2011KhanspersModified description
44028view23:03, 22 August 2011KhanspersUpdating pathway from NetSlim
41145view23:39, 1 March 2011MaintBotRemoved redundant pathway information and comments
35641view21:29, 12 February 2010KhanspersModified description
20779view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-2 NetPath 14]] moved to [[Pathway:WP49]]: Moved to stable identifier
8164view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-2 NetPath 14]] moved to [[Pathway:Homo sapiens:IL-2 NetPath 14]]: Renaming species
7702view16:10, 18 December 2007MaintBotfixed category names
7241view12:41, 4 November 2007MaintBotAdded categories to GPML
6335view22:17, 22 May 2007A.Pandeygpml file for [[Human:IL-2_NetPath_14]]

External references


View all...
NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
BCL2GeneProduct596 (Entrez Gene)
CBLGeneProduct867 (Entrez Gene)
CD53GeneProduct963 (Entrez Gene)
CHUKGeneProduct1147 (Entrez Gene)
CISHGeneProduct1154 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
CRKLGeneProduct1399 (Entrez Gene)
EIF3S9GeneProduct8662 (Entrez Gene)
EIF4EGeneProduct1977 (Entrez Gene)
ETS1GeneProduct2113 (Entrez Gene)
ETS2GeneProduct2114 (Entrez Gene)
FOXO3AGeneProduct2309 (Entrez Gene)
FRAP1GeneProduct2475 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene)
GAB2GeneProduct9846 (Entrez Gene)
GNB2L1GeneProduct10399 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
HSPCAGeneProduct3320 (Entrez Gene)
ICAM1GeneProduct3383 (Entrez Gene)
IFNA1GeneProduct3439 (Entrez Gene)
IL2GeneProduct3558 (Entrez Gene)
IL2RAGeneProduct3559 (Entrez Gene)
IL2RBGeneProduct3560 (Entrez Gene)
IL2RGGeneProduct3561 (Entrez Gene)
IRS1GeneProduct3667 (Entrez Gene)
IRS2GeneProduct8660 (Entrez Gene)
ITM2BGeneProduct9445 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
JAK3GeneProduct3718 (Entrez Gene)
KRASGeneProduct3845 (Entrez Gene)
LCKGeneProduct3932 (Entrez Gene)
LYNGeneProduct4067 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MAPKAPK2GeneProduct9261 (Entrez Gene)
MKNK1GeneProduct8569 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
NMIGeneProduct9111 (Entrez Gene)
NR3C1GeneProduct2908 (Entrez Gene)
NSEP1GeneProduct4904 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PLCB1GeneProduct23236 (Entrez Gene)
PRKCZGeneProduct5590 (Entrez Gene)
PTK2BGeneProduct2185 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PTPN6GeneProduct5777 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RPS6KB1GeneProduct6198 (Entrez Gene)
SHBGeneProduct6461 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SOCS1GeneProduct8651 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
STAM2GeneProduct10254 (Entrez Gene)
STAMGeneProduct8027 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
STAT5AGeneProduct6776 (Entrez Gene)
STAT5BGeneProduct6777 (Entrez Gene)
SYKGeneProduct6850 (Entrez Gene)
TERTGeneProduct7015 (Entrez Gene)
VAV1GeneProduct7409 (Entrez Gene)

Annotated Interactions

No annotated interactions
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