COVID-19 Adverse Outcome Pathway (Homo sapiens)

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311LegendKE1 (KE:1738) - Enhanced viral entry and gene expressionKE3 (KE:1750) - Increase inflammatory immune responsesKE2 (KE:1496) - Increased, secretion of proinflammatory and profibrotic mediatorsEvents related to the Adverse Outcome Pathway forAcute respiratory distress associated mortality (AOP:320)AO (KE:1751) - Increased mortalityKE4 (KE:1748) - Increase, the risk of acute respiratory failureMIEMIE (KE:1739) - Binding of S protein to ACE receptor15 genes included in the pathway:genes with direct evidence of associationto COVID-19 in the Comparative Toxicogenomics Database(http://ctdbase.org/)1, 2SARS-CoV-2 and Angiotensin-convertingenzyme 2 (ACE2) receptor:Molecular mechanisms andpotential therapeutic target(Homo sapiens)CXCL10ACE2CCL3IL8Lung fibrosisToll-likereceptor signalingCSF3IL6TMPRSS2IL2RAIL7LTF danger signalresponse pathwaypositive regulation ofleukocyte activationCytokines andinflammatoryresponseIL10AGTIL1BTNFSARS-CoV-2 andCOVID-19 PathwayIL2CCL21KE2KE1KE3


Description

Experimental pathway to investigate overlap of Covid-19 downstream effects and adverse outcome pathways related to lung injury.

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Ontology Terms

 

Bibliography

  1. Nymark P, Rieswijk L, Ehrhart F, Jeliazkova N, Tsiliki G, Sarimveis H, Evelo CT, Hongisto V, Kohonen P, Willighagen E, Grafström RC; ''A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions.''; Toxicol Sci, 2018 PubMed Europe PMC Scholia
  2. Labib S, Williams A, Yauk CL, Nikota JK, Wallin H, Vogel U, Halappanavar S; ''Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes.''; Part Fibre Toxicol, 2016 PubMed Europe PMC Scholia
  3. Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S; ''A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.''; Circ Res, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
111616view20:41, 29 August 2020EgonwModified title
111408view16:12, 6 August 2020EveloModified title
111156view08:39, 21 July 2020EgonwAnother pathway clickable
111112view09:12, 13 July 2020EgonwMade the pathways clickable
110309view16:07, 3 May 2020EgonwAdded missing @Type annotation
110048view08:34, 15 April 2020PennyUpdated connection between ACE2 and AGT. Added link to WP4883.
109962view08:48, 8 April 2020PennyAdded date of access for CTD
109961view08:47, 8 April 2020PennyAdded reference to origin of genes
109960view08:39, 8 April 2020PennyUpdates in line with AOP:320 and analysis of COVID-19 genes
109947view13:34, 7 April 2020FehrhartOntology Term : 'signaling pathway' added !
109944view13:23, 7 April 2020PennyNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACE2GeneProduct59272 (Entrez Gene)
AGTGeneProduct183 (Entrez Gene)
CCL2GeneProduct6347 (Entrez Gene)
CCL3GeneProduct6348 (Entrez Gene)
CSF3GeneProduct1440 (Entrez Gene)
CXCL10GeneProduct3627 (Entrez Gene)
Cytokines and

inflammatory

response
PathwayWP530 (WikiPathways)
IL10GeneProduct3586 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL2GeneProduct3558 (Entrez Gene)
IL2RAGeneProduct3559 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL7GeneProduct3574 (Entrez Gene)
IL8GeneProduct3576 (Entrez Gene)
LTF danger signal response pathwayPathwayWP4478 (WikiPathways)
Lung fibrosisPathwayWP3624 (WikiPathways)
SARS-CoV-2 and COVID-19 PathwayPathwayWP4846 (WikiPathways)
SARS-CoV-2 and Angiotensin-converting

enzyme 2 (ACE2) receptor: Molecular mechanisms and potential therapeutic target

(Homo sapiens)
PathwayWP4883 (WikiPathways)
TMPRSS2GeneProduct7113 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
Toll-like receptor signalingPathwayWP75 (WikiPathways)
positive regulation of leukocyte activationPathwayGO:0002696 (Other)

Annotated Interactions

SourceTargetTypeDatabase referenceComment
ACE2AGTmim-modification882484 (BioGrid) Proteolytic processing
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