COVID-19 AOP (Homo sapiens)

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11KE3 (KE:1750) - Increase inflammatory immune responsesKE1 (KE:1738) - Enhanced viral entry and gene expressionKE4 (KE:1748) - Increase, the risk of acute respiratory failureAO (KE:1751) - Increased mortalityMIE (KE:1739) - Binding of S protein to ACE receptorEvents related to the Adverse Outcome Pathway forAcute respiratory distress associated mortality (AOP:320)LegendMIEKE2 (KE:1496) - Increased, secretion of proinflammatory and profibrotic mediators1, 2AGTIL1BCytokines andinflammatoryresponseACE2IL2CCL3Lung fibrosisTNFLTF danger signalresponse pathwayCXCL10IL6CSF3SARS-CoV-2 andCOVID-19 PathwayIL8TMPRSS2IL10positive regulation ofleukocyte activationIL7Toll-likereceptor signalingCCL2IL2RA1KE2KE1KE3


Description

Experimental pathway to investigate overlap of Covid-19 downstream effects and adverse outcome pathways related to lung injury.

Quality Tags

Ontology Terms

 

Bibliography

  1. Nymark P, Rieswijk L, Ehrhart F, Jeliazkova N, Tsiliki G, Sarimveis H, Evelo CT, Hongisto V, Kohonen P, Willighagen E, Grafström RC; ''A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions.''; Toxicol Sci, 2018 PubMed Europe PMC Scholia
  2. Labib S, Williams A, Yauk CL, Nikota JK, Wallin H, Vogel U, Halappanavar S; ''Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes.''; Part Fibre Toxicol, 2016 PubMed Europe PMC Scholia
  3. Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S; ''A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.''; Circ Res, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
110309view16:07, 3 May 2020EgonwAdded missing @Type annotation
110048view08:34, 15 April 2020PennyUpdated connection between ACE2 and AGT. Added link to WP4883.
109962view08:48, 8 April 2020PennyAdded date of access for CTD
109961view08:47, 8 April 2020PennyAdded reference to origin of genes
109960view08:39, 8 April 2020PennyUpdates in line with AOP:320 and analysis of COVID-19 genes
109947view13:34, 7 April 2020FehrhartOntology Term : 'signaling pathway' added !
109944view13:23, 7 April 2020PennyNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACE2GeneProduct59272 (Entrez Gene)
AGTGeneProduct183 (Entrez Gene)
CCL2GeneProduct6347 (Entrez Gene)
CCL3GeneProduct6348 (Entrez Gene)
CSF3GeneProduct1440 (Entrez Gene)
CXCL10GeneProduct3627 (Entrez Gene)
Cytokines and

inflammatory

response
PathwayWP530 (WikiPathways)
IL10GeneProduct3586 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL2GeneProduct3558 (Entrez Gene)
IL2RAGeneProduct3559 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL7GeneProduct3574 (Entrez Gene)
IL8GeneProduct3576 (Entrez Gene)
LTF danger signal response pathwayPathwayWP4478 (WikiPathways)
Lung fibrosisPathwayWP3624 (WikiPathways)
SARS-CoV-2 and COVID-19 PathwayPathwayWP4846 (WikiPathways)
TMPRSS2GeneProduct7113 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
Toll-like receptor signalingPathwayWP75 (WikiPathways)
positive regulation of leukocyte activationGO:0002696 (Other)

Annotated Interactions

No annotated interactions

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