Pathogenesis of SARS-CoV-2 Mediated by nsp9-nsp10 Complex (Homo sapiens)

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HLA-DRB5NLRP1MMP25IGHG2CD2CD4IL-8LBPPRG3HLA-DRB4Envelope (E)IGHEIGHG4NKRFIGHG1HLA-DRAnsp9CD8ACRPHLA-DRB1IGLC2IGLL1chemotaxisCD8Ansp101IL-6CD247CD3GLCKCD3EZAP70TRBC1FYNTRACNeutrophil activationOpen reading frames (ORFs)Glycoprotein spike (S)SARS-CoV-2 (~30 kb)Membrane (M)Nucleocapsid (N)]Structural proteinsNonstructural proteinsnsp1 to nsp16Accessory proteinsORF3a, ORF6, ORF7a, ORF7b, ORF8, ORF9a, ORF9b, and ORF10TCR signaling kinasesImmunoglobulin subunitsT cell receptor(TCR)subunits T cell surface moleculesMHC class II moleculesSARS-CoV-2 viralproteinsActivationPositive regulation of gene expressionNegative regulation of gene expressionLegend


Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

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  1. Qiming Liang, Jingjiao Li, Mingquan Guo, Xiaoxu Tian, Chengrong Liu, Xin Wang, Xing Yang, Ping Wu, Zixuan Xiao, View ORCID ProfileYafei Qu, Yue Yin, Joyce Fu, Zhaoqin Zhu, Zhenshan Liu, Chao Peng, Tongyu Zhu; ''Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis'';, 2020


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111618view20:42, 29 August 2020EgonwModified title
111113view09:20, 13 July 2020EgonwMade the include pathway clickable
110229view14:23, 27 April 2020EgonwAdded the NCBI gene identifier for LBP
110023view19:22, 12 April 2020AlexanderPicoOntology Term : 'regulatory pathway' added !
110022view19:21, 12 April 2020AlexanderPicoOntology Term : 'inflammatory response pathway' added !
110021view19:21, 12 April 2020AlexanderPicoOntology Term : 'disease pathway' added !
110020view19:20, 12 April 2020AlexanderPicoOntology Term : 'severe acute respiratory syndrome' added !
110019view19:20, 12 April 2020AlexanderPicoModified title
110017view19:18, 12 April 2020AlexanderPicoUpdated representation of ORFs and interactions per standards
109953view18:43, 7 April 2020EgonwAdded two identifiers.
109923view17:40, 6 April 2020Khanspersfixed unconnected
109916view16:58, 6 April 2020KhanspersOntology Term : 'viral infectious disease' added !
109904view19:59, 5 April 2020Rex D A BInteractions
109895view18:25, 4 April 2020Rex D A BNew pathway

External references


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NameTypeDatabase referenceComment
T cell surface moleculesPathway
Accessory proteinsPathway
CD247GeneProduct919 (Entrez Gene)
CD2GeneProduct914 (Entrez Gene)
CD3EGeneProduct916 (Entrez Gene)
CD3G GeneProduct917 (Entrez Gene)
CD4GeneProduct920 (Entrez Gene)
CD8AGeneProduct925 (Entrez Gene)
CD8AGeneProduct926 (Entrez Gene)
CRPGeneProduct1401 (Entrez Gene)
Envelope (E)Pathway
FYNGeneProduct2534 (Entrez Gene)
Glycoprotein spike (S)Pathway
HLA-DRAGeneProduct3122 (Entrez Gene)
HLA-DRB1GeneProduct3123 (Entrez Gene)
HLA-DRB4GeneProduct3126 (Entrez Gene)
HLA-DRB5GeneProduct3127 (Entrez Gene)
IGHEGeneProduct3497 (Entrez Gene)
IGHG1GeneProduct3500 (Entrez Gene)
IGHG2GeneProduct3501 (Entrez Gene)
IGHG4GeneProduct3503 (Entrez Gene)
IGLC2GeneProduct3538 (Entrez Gene)
IGLL1GeneProduct3543 (Entrez Gene)
IL-6GeneProduct3569 (Entrez Gene)
IL-8GeneProduct3576 (Entrez Gene)
Immunoglobulin subunitsPathway
LBPGeneProductLBP (Entrez Gene)
LCKGeneProduct3932 (Entrez Gene)
MHC class II moleculesPathway
MMP25 GeneProduct64386 (Entrez Gene)
Membrane (M)Pathway
NKRFGeneProduct55922 (Entrez Gene)
NLRP1GeneProduct5725029 (Entrez Gene)
Negative regulation of gene expression
Neutrophil activationPathway
Nonstructural proteinsPathway
Nucleocapsid (N)]Pathway
ORF3a, ORF6, ORF7a,

ORF7b, ORF8, ORF9a,

ORF9b, and ORF10
Open reading frames (ORFs)Pathway
PRG3GeneProduct10394 (Entrez Gene)
Positive regulation of gene expression
SARS-CoV-2 (~30 kb)Pathway
SARS-CoV-2 viral proteinsPathway
Structural proteinsPathway
T cell receptor(TCR) subunitsPathway
TCR signaling kinasesPathway
TRACGeneProduct28755 (Entrez Gene)
TRBC1 GeneProduct28639 (Entrez Gene)
ZAP70GeneProduct7535 (Entrez Gene)
nsp1 to nsp16Pathway

Annotated Interactions

No annotated interactions

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