Pathogenesis of SARS-CoV-2 Mediated by nsp9-nsp10 Complex (Homo sapiens)

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T cell receptor(TCR)subunitsSARS-CoV-2 viralproteinsImmunoglobulin subunitsMembrane (M)chemotaxisnsp1 to nsp16Nucleocapsid (N)]TCR signaling kinasesORF3a, ORF6, ORF7a, ORF7b, ORF8, ORF9a, ORF9b, and ORF10 T cell surface moleculesMHC class II moleculesEnvelope (E)Neutrophil activationGlycoprotein spike (S)CD2CRPCD8ACD8APRG3IL-8CD4nsp9IGHG1IGLC2IGHELBPIGHG4HLA-DRAIGLL1MMP25NLRP1nsp10IGHG2HLA-DRB5NKRFHLA-DRB1HLA-DRB4IL-61CD247CD3GLCKCD3EZAP70TRBC1FYNTRACOpen reading frames (ORFs)SARS-CoV-2 (~30 kb)Structural proteinsNonstructural proteinsAccessory proteinsActivationPositive regulation of gene expressionNegative regulation of gene expressionLegend


Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

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Ontology Terms



  1. Qiming Liang, Jingjiao Li, Mingquan Guo, Xiaoxu Tian, Chengrong Liu, Xin Wang, Xing Yang, Ping Wu, Zixuan Xiao, View ORCID ProfileYafei Qu, Yue Yin, Joyce Fu, Zhaoqin Zhu, Zhenshan Liu, Chao Peng, Tongyu Zhu; ''Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis'';, 2020


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111618view20:42, 29 August 2020EgonwModified title
111113view09:20, 13 July 2020EgonwMade the include pathway clickable
110229view14:23, 27 April 2020EgonwAdded the NCBI gene identifier for LBP
110023view19:22, 12 April 2020AlexanderPicoOntology Term : 'regulatory pathway' added !
110022view19:21, 12 April 2020AlexanderPicoOntology Term : 'inflammatory response pathway' added !
110021view19:21, 12 April 2020AlexanderPicoOntology Term : 'disease pathway' added !
110020view19:20, 12 April 2020AlexanderPicoOntology Term : 'severe acute respiratory syndrome' added !
110019view19:20, 12 April 2020AlexanderPicoModified title
110017view19:18, 12 April 2020AlexanderPicoUpdated representation of ORFs and interactions per standards
109953view18:43, 7 April 2020EgonwAdded two identifiers.
109923view17:40, 6 April 2020Khanspersfixed unconnected
109916view16:58, 6 April 2020KhanspersOntology Term : 'viral infectious disease' added !
109904view19:59, 5 April 2020Rex D A BInteractions
109895view18:25, 4 April 2020Rex D A BNew pathway

External references


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NameTypeDatabase referenceComment
Accessory proteinsPathway
CD247GeneProduct919 (Entrez Gene)
CD2GeneProduct914 (Entrez Gene)
CD3EGeneProduct916 (Entrez Gene)
CD3G GeneProduct917 (Entrez Gene)
CD4GeneProduct920 (Entrez Gene)
CD8AGeneProduct925 (Entrez Gene)
CD8AGeneProduct926 (Entrez Gene)
CRPGeneProduct1401 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene)
HLA-DRAGeneProduct3122 (Entrez Gene)
HLA-DRB1GeneProduct3123 (Entrez Gene)
HLA-DRB4GeneProduct3126 (Entrez Gene)
HLA-DRB5GeneProduct3127 (Entrez Gene)
IGHEGeneProduct3497 (Entrez Gene)
IGHG1GeneProduct3500 (Entrez Gene)
IGHG2GeneProduct3501 (Entrez Gene)
IGHG4GeneProduct3503 (Entrez Gene)
IGLC2GeneProduct3538 (Entrez Gene)
IGLL1GeneProduct3543 (Entrez Gene)
IL-6GeneProduct3569 (Entrez Gene)
IL-8GeneProduct3576 (Entrez Gene)
LBPGeneProductLBP (Entrez Gene)
LCKGeneProduct3932 (Entrez Gene)
MMP25 GeneProduct64386 (Entrez Gene)
NKRFGeneProduct55922 (Entrez Gene)
NLRP1GeneProduct5725029 (Entrez Gene)
Negative regulation of gene expression
Nonstructural proteinsPathway
Open reading frames (ORFs)Pathway
PRG3GeneProduct10394 (Entrez Gene)
Positive regulation of gene expression
SARS-CoV-2 (~30 kb)Pathway
Structural proteinsPathway
TRACGeneProduct28755 (Entrez Gene)
TRBC1 GeneProduct28639 (Entrez Gene)
ZAP70GeneProduct7535 (Entrez Gene)
nsp10ProteinQ87917572 (Wikidata)
nsp9ProteinQ89686805 (Wikidata)

Annotated Interactions

No annotated interactions

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