Host-pathogen interaction of human corona viruses - MAPK signaling (Homo sapiens)

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21SARSphos-T573SARSinfectionp38 pathwayMAP3K10MAPK9MAPK3MAP2K2FOSMAP2K4MAPK11MAPK1MAP2K1MAP3K4MAP3K9MAP2K3MAPK14JUNMAP2K63aSDDIT3MAPK10RPS6KA1MAP2K7MAPK12ATF2RPS6KA3FOSMAPK13RAF1EIF4ERPS6KA2MAP3K11MAPK8BCL2MAP3K11phos-S380SARS, MERS, 229Einfection3bVLP7aSARSSARS, MERS, 229E infectionSARS, 229EIBV infectionS3a7aN3b6SARSCell survival and proliferationProteinsynthesisApoptosisInnateimmunityAutophagyIFI271BST2JUNBIFITM2IFITM3IFITM11Effectors to fight virusIFI27BST21IFITM2IFITM3IFITM11ERK pathwayJNK pathwayAP-1 complex


Description

This pathway describes the activation of the human MAPK signaling system during human coronavirus infection. The information is based on the review of Fung and Liu, Figure 7 [10.1146/annurev-micro-020518-115759]. The MAPK signaling system is an important system to regulate response to different environmental stimuli, e.g. inflammation upon an infection. Their downstream effects include regulation of cell cycle, apoptosis, differentiation and immune response. During corona virus infection three MAPK signaling pathways were studied and described. The p38 pathway (MAPK11 - 14) leads to stimulation of apoptosis via CHOP (DDIT3) while the ERK pathway (MAPK1 and MAPK3) counteracts apoptosis stimulation and supports cell survival by stimulation of ATF2 and FOS. The JNK pathway (MAPK 8-10) inhibits cell survival protein BCL2 thus stimulating apoptosis but also stimulating the AP1 complex that leads to the production of effectors to fight the infection. The interplay of apoptosis stimulation and cell survival is not yet fully understood in SARS-CoV infection.

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Ontology Terms

 

Bibliography

  1. Lulin Huang, Yi Shi, Bo Gong, Li Jiang, Xiaoqi Liu, Jialiang Yang, Juan Tang, Chunfang You, Qi Jiang, Bo Long, Tao Zeng, Mei Luo, Fanwei Zeng, Fanxin Zeng, Shuqiang Wang, Xingxiang Yang, Zhenglin Yang; ''Blood single cell immune profiling reveals the interferon-MAPK pathway mediated adaptive immune response for COVID-19''; https://doi.org/10.1101/2020.03.15.20033472, 2020
  2. Fung TS, Liu DX; ''Human Coronavirus: Host-Pathogen Interaction.''; Annu Rev Microbiol, 2019 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
110827view20:54, 10 June 2020Mkutmonfixed publication xrefs
110824view09:45, 10 June 2020FehrhartModified description
110823view09:41, 10 June 2020Fehrhartadded labels for different MAPK pathways
110822view09:22, 10 June 2020Fehrhartupdated transcription/translation
110322view22:54, 3 May 2020Marvin M2Connected unconnected lines
110252view11:25, 30 April 2020Fehrhartmodified graphics
110210view13:10, 24 April 2020EgonwTyped proteins as Type="Protein"
110043view16:56, 14 April 2020Khanspersfixed unconnected
110040view15:18, 14 April 2020Rex D A BInterferon-MAPK Pathway in Response to SARS-CoV-2 Infection
109978view18:20, 8 April 2020AlexanderPicoupdated sars nodes per #covidpathways guidelines
109951view18:29, 7 April 2020EgonwAdded three more identifiers.
109851view11:41, 2 April 2020Fehrhartchanged virus protein visualization
109815view14:47, 1 April 2020Fehrhartadded another virus protein ID
109813view14:45, 1 April 2020Fehrhartadded some virus ID
109810view12:57, 1 April 2020FehrhartOntology Term : 'p38 MAPK signaling pathway' added !
109809view12:57, 1 April 2020FehrhartOntology Term : 'signaling pathway' added !
109808view12:57, 1 April 2020FehrhartOntology Term : 'severe acute respiratory syndrome' added !
109807view12:56, 1 April 2020FehrhartOntology Term : 'viral infectious disease' added !
109806view12:55, 1 April 2020Fehrhartwork in progress
109805view12:40, 1 April 2020Fehrhartwork in progress
109804view12:26, 1 April 2020FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3aProteinP59632 (Uniprot-TrEMBL)
3bProteinP59633 (Uniprot-TrEMBL)
6ProteinP59634 (Uniprot-TrEMBL)
7aProteinP59635 (Uniprot-TrEMBL)
ATF2GeneProductENSG00000115966 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BST2GeneProduct684 (Entrez Gene)
DDIT3GeneProductENSG00000175197 (Ensembl) CHOP
EIF4EGeneProductENSG00000151247 (Ensembl)
FOSGeneProductENSG00000170345 (Ensembl) c-FOS
IFI27GeneProduct3429 (Entrez Gene)
IFITM1ProteinENSG00000185885 (Ensembl)
IFITM2ProteinENSG00000185201 (Ensembl)
IFITM3ProteinENSG00000142089 (Ensembl)
JUNBGeneProduct3726 (Entrez Gene)
JUNGeneProductENSG00000177606 (Ensembl) AP1
MAP2K1GeneProductENSG00000169032 (Ensembl) MKK1
MAP2K2GeneProductENSG00000126934 (Ensembl) MKK2
MAP2K3GeneProductENSG00000034152 (Ensembl) MKK3
MAP2K4GeneProductENSG00000065559 (Ensembl) MKK4
MAP2K6GeneProductENSG00000108984 (Ensembl) MKK6
MAP2K7GeneProductENSG00000076984 (Ensembl) MKK7
MAP3K10GeneProductENSG00000130758 (Ensembl) MLK2
MAP3K11GeneProductENSG00000173327 (Ensembl) MLK3
MAP3K1GeneProductENSG00000095015 (Ensembl) MEKK1
MAP3K4GeneProductENSG00000085511 (Ensembl) MEKK4
MAP3K9GeneProductENSG00000006432 (Ensembl) MLK1
MAPK10GeneProduct5602 (Entrez Gene) JNK
MAPK11GeneProduct5600 (Entrez Gene) p38
MAPK12GeneProduct6300 (Entrez Gene) p38
MAPK13GeneProduct5603 (Entrez Gene) p38
MAPK14GeneProductENSG00000112062 (Ensembl) p38
MAPK1GeneProduct5594 (Entrez Gene) ERK2
MAPK3GeneProduct5595 (Entrez Gene) ERK1
MAPK8GeneProduct5599 (Entrez Gene) JNK
MAPK9GeneProduct5601 (Entrez Gene) JNK
NProteinQ89457519 (Wikidata)
RAF1GeneProductENSG00000132155 (Ensembl)
RPS6KA1GeneProductENSG00000117676 (Ensembl) RSK
RPS6KA2GeneProductENSG00000071242 (Ensembl) RSK
RPS6KA3GeneProductENSG00000177189 (Ensembl) RSK
SProteinQ89458416 (Wikidata)
VLPProtein

Annotated Interactions

No annotated interactions

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