Peroxiredoxin 2 induced ovarian failure (Homo sapiens)

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1Ovarian failureOvarian functional degenerationAgingSize of ovaries declineOvarian structural degenerationApoptosisThe number of follicles and Corpora lutea declinesJNKCYP11A1ProgesteroneHSD3B2Cytochrome CEstradiol-17betaPARP2BAXPeroxiredoxin-2STARReactive oxygen species CASP3


Description

This pathway summarizes the influence of reactive oxygen species on ovarian aging, ovarian failure and therefore female infertility.

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway [WP4835_109250.gpml] with a 62.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Park SJ, Kim JH, Lee DG, Kim JM, Lee DS; ''Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice.''; Free Radic Biol Med, 2018 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
110299view15:10, 2 May 2020EgonwReplaced secondary ChEBI identifiers with a primary identifiers.
110067view08:43, 16 April 2020FehrhartOntology Term : 'ovarian dysfunction' added !
110066view08:42, 16 April 2020FehrhartOntology Term : 'c-Jun N-terminal kinases MAPK signaling pathway' added !
110065view08:41, 16 April 2020FehrhartModified description
110064view08:39, 16 April 2020FehrhartGraphical adjustments
110063view08:37, 16 April 2020FehrhartAdded reference
109748view15:08, 30 March 2020Bas LahaijeNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BAXGeneProductENSG00000087088 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000003873
CASP3ProteinENSG00000164305 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:A0A1B0GRX1
CYP11A1ProteinENSG00000140459 (Ensembl)
  • Mitochondrial
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9QZ82
Cytochrome CMetaboliteCHEBI:4062 (ChEBI)
  • Somatic
  • Multiple homologues found: En:ENSG00000172115;En:ENSG00000172115;
Estradiol-17betaMetaboliteCHEBI:4864 (ChEBI)
HSD3B2ProteinENSG00000203859 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:E9PXG7
JNKProteinP53779 (Uniprot-TrEMBL)
PARP2GeneProductENSG00000129484 (Ensembl)
Peroxiredoxin-2ProteinP32119 (Uniprot-TrEMBL) No homologues found for original id S:Q61171
ProgesteroneMetaboliteDB00396 (DrugBank)
Reactive oxygen species MetaboliteCHEBI:26523 (ChEBI)
STARProteinENSG00000147465 (Ensembl)
  • Mitichondrial
  • Type your comment here
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P51557

Annotated Interactions

No annotated interactions
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