Kisspeptin/Kisspeptin Receptor System in the Ovary (Homo sapiens)

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1Gene productPathwayRafSteroidogenesisGq/11 protein signallingOocyte maturationConversionInhibitionStimulationIntracellular spaceIndirect stimulationMekProtein kinase COvulationFollicular developmentIndirect conversion/interactionLegendErkCatalysisMetaboliteRasPRKCHPIK3CBKISS1IP3PLCB4NRASKISS1RARRB1AKT2BMP15NKBPRKCGGDF9DAGPIP3MAP2K2PathwayFSHRPLCB1PRKCBHSD3B1PIK3CANFKB1Ca2+STARMAPK3AKT1HRASKRASPLCB3PI3K/Akt signalling pathwayPIK3CGPRKCEPRKCQAMHRAF1PDK1CYP11A1MAPK signalling pathwayMMP9MAPK1GeneMAP2K1PIP2PLCB2progesteroneARRB2PIK3CDMetPRKCAPRKCDExtracellular space


Description

The signalling pathway of the kisspeptin/kisspeptin receptor interaction in the ovary, including its effects on follicular development, oocyte maturation, ovulation, and steroidogenesis.

Quality Tags

Ontology Terms

 

Bibliography

  1. Hu KL, Zhao H, Chang HM, Yu Y, Qiao J; ''Kisspeptin/Kisspeptin Receptor System in the Ovary.''; Front Endocrinol (Lausanne), 2017 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
110295view14:23, 2 May 2020EgonwReplaced secondary ChEBI identifiers with a primary identifiers.
110078view09:06, 16 April 2020FehrhartChanged pathway to label in legend
110077view09:04, 16 April 2020FehrhartConverted interactions in legend to graphical lines
109733view22:00, 29 March 2020MCMJanssenOntology Term : 'ovarian disease' added !
109732view21:59, 29 March 2020MCMJanssenOntology Term : 'female reproductive system disease' added !
109731view21:59, 29 March 2020MCMJanssenOntology Term : 'sex steroids signaling pathway' added !
109730view21:58, 29 March 2020MCMJanssenOntology Term : 'nuclear factor kappa B signaling pathway' added !
109729view21:58, 29 March 2020MCMJanssenOntology Term : 'protein kinase C (PKC) signaling pathway' added !
109728view21:57, 29 March 2020MCMJanssenOntology Term : 'peptide and protein hormone signaling pathway' added !
109727view21:57, 29 March 2020MCMJanssenOntology Term : 'G protein mediated signaling pathway' added !
109722view17:21, 29 March 2020MCMJanssenNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AMHGeneProductENSG00000104899 (Ensembl)
ARRB1GeneProductENSG00000137486 (Ensembl)
ARRB2GeneProductENSG00000141480 (Ensembl)
BMP15GeneProductENSG00000130385 (Ensembl)
CYP11A1GeneProductENSG00000140459 (Ensembl)
Ca2+MetaboliteCHEBI:3308 (ChEBI)
DAGMetaboliteCHEBI:4481 (ChEBI)
FSHRGeneProductENSG00000170820 (Ensembl)
GDF9GeneProductENSG00000164404 (Ensembl)
GeneGeneProduct
HRASGeneProductENSG00000174775 (Ensembl)
HSD3B1GeneProductENSG00000203857 (Ensembl)
IP3MetaboliteCHEBI:16595 (ChEBI)
KISS1GeneProductENSG00000170498 (Ensembl)
KISS1RGeneProductENSG00000116014 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAPK signalling pathwayPathwayWP382 (WikiPathways)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
MetMetabolite
NFKB1GeneProductENSG00000109320 (Ensembl)
NKBMetaboliteQ412604 (Wikidata)
NRASGeneProductENSG00000213281 (Ensembl)
PDK1GeneProductENSG00000152256 (Ensembl)
PI3K/Akt signalling pathwayPathwayWP4172 (WikiPathways)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3CGGeneProductENSG00000105851 (Ensembl)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PLCB1GeneProductENSG00000182621 (Ensembl)
PLCB2GeneProductENSG00000137841 (Ensembl)
PLCB3GeneProductENSG00000149782 (Ensembl)
PLCB4GeneProductENSG00000101333 (Ensembl)
PRKCAGeneProductENSG00000154229 (Ensembl)
PRKCBGeneProductENSG00000166501 (Ensembl)
PRKCDGeneProductENSG00000163932 (Ensembl)
PRKCEGeneProductENSG00000171132 (Ensembl)
PRKCGGeneProductENSG00000126583 (Ensembl)
PRKCHGeneProductENSG00000027075 (Ensembl)
PRKCQGeneProductENSG00000065675 (Ensembl)
PathwayPathway
RAF1GeneProductENSG00000132155 (Ensembl)
STARGeneProductENSG00000147465 (Ensembl)
progesteroneMetaboliteCHEBI:8453 (ChEBI)

Annotated Interactions

No annotated interactions

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