Host-pathogen interaction of human coronaviruses - autophagy (Homo sapiens)

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12DMV double membrane vesicleAutophagosomeLegendEDEMosomeLysozomeMaturationvirus proteinphosphorylationSARS, IBV, MHV(inactive)InitiationPIK3R4RB1CC1MTORZFYVE1autophagyinitiationcomplexWIPI1ULK1PIK3C3ULK2BECN1nsp6ULK1PPPULK2PMTORERNucleationElongationnsp567PRRSVMHV, EAVinfectionSARS, IBV, MHVnsp6nsp567PRRSVAutolysosomevirus type/speciesPhosphorylationPRRSVPATG13PATG7ATG10ATG5ATG12ATG12ATG5ATG16L1ATG3ATG4AATG7ATG16L2ATG16L1ATG16L2ATG5ATG12PELC3LC3PEATG13P


This pathway describes the induction and modulation of the human autophagy system during human coronavirus infection. The information is based on the review of Fung and Liu [10.1146/annurev-micro-020518-115759]. Autophagy is usually a stress mediated defense mechanism and can protect against pathogen infection. On the other hand it is known from several viruses that they can hijack the cellular autophagy system for proliferation [10.1074/jbc.M306124200]. For human coronaviruses it is presumed that coronaviruses stimulate the initiation of autophagy due to infection initiated stress for which PIK3R4 (VPS15), PIK3C3 (VPS34) and BECN1 (beclin1) are key proteins. Additionally, nsp6 (and nsp567 from other virus species than SARS-CoV) inhibit maturation of autolysosomes. Nsp6 is involved in the formation of double membrane vesicles and therefore has side effects on the formation of normal cellular vesicles [10.4161/auto.29309].

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Ontology Terms



  1. Fung TS, Liu DX; ''Human Coronavirus: Host-Pathogen Interaction.''; Annu Rev Microbiol, 2019 PubMed Europe PMC Scholia
  2. Cottam EM, Whelband MC, Wileman T; ''Coronavirus NSP6 restricts autophagosome expansion.''; Autophagy, 2014 PubMed Europe PMC Scholia


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116597view19:12, 8 May 2021EweitzModified title
112163view18:30, 29 September 2020Khanspersfixed ptm state comments
110820view07:40, 10 June 2020FehrhartModified description
110819view07:38, 10 June 2020Fehrhartadded reference
110814view22:43, 9 June 2020Mkutmonfixed unconnected line
110727view19:00, 29 May 2020Khansperschanged xrefs to uniprot
110726view18:47, 29 May 2020Khanspersupdated legend, updated ATG part, changed free labels into labels on objects
110725view17:58, 29 May 2020Khanspersadded phosphosites for ULK1, updated representation of ULK/ATG13 dephosphorylation, updated legend
110204view10:47, 24 April 2020Fehrhartupdated legend
110199view20:38, 23 April 2020EgonwTyped proteins as Type="Protein"
109983view21:26, 8 April 2020EgonwAdded possibly the first complex identifier.
109982view21:13, 8 April 2020EgonwAdded a Complex data node (with title from Complex Portal)
109972view18:17, 8 April 2020AlexanderPicoupdated sars nodes per #covidpathways guidelines
109848view11:34, 2 April 2020Fehrhartchanged virus protein visualization
109820view15:01, 1 April 2020FehrhartFixed a comment error
109633view18:28, 27 March 2020AlexanderPicoOntology Term : 'autophagy pathway' added !
109629view18:26, 27 March 2020AlexanderPicoOntology Term : 'severe acute respiratory syndrome' added !
109628view18:21, 27 March 2020AlexanderPicoAdded P and L modifications as states
109627view18:09, 27 March 2020FehrhartOntology Term : 'viral infectious disease' added !
109626view18:09, 27 March 2020FehrhartOntology Term : 'disease pathway' added !
109625view18:09, 27 March 2020FehrhartModified title
109624view18:06, 27 March 2020FehrhartNew pathway

External references


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NameTypeDatabase referenceComment
ATG10ProteinQ9H0Y0 (Uniprot-TrEMBL)
ATG12ProteinO94817 (Uniprot-TrEMBL)
ATG13GeneProductENSG00000175224 (Ensembl)
ATG13ProteinO75143 (Uniprot-TrEMBL)
ATG16L1ProteinQ676U5 (Uniprot-TrEMBL)
ATG16L2ProteinQ8NAA4 (Uniprot-TrEMBL)
ATG3ProteinQ9NT62 (Uniprot-TrEMBL)
ATG4AProteinQ8WYN0 (Uniprot-TrEMBL)
ATG5ProteinQ9H1Y0 (Uniprot-TrEMBL)
ATG7ProteinO95352 (Uniprot-TrEMBL)
BECN1ProteinQ14457 (Uniprot-TrEMBL) beclin 1
LC3GeneProductQ9H492 (Uniprot-TrEMBL)
MTORProteinP42345 (Uniprot-TrEMBL)
PEMetabolite16038 (ChEBI)
PIK3C3ProteinQ8NEB9 (Uniprot-TrEMBL) VPS34
PIK3R4ProteinQ99570 (Uniprot-TrEMBL) VPS15
RB1CC1ProteinQ8TDY2 (Uniprot-TrEMBL) FIP200
ULK1ProteinO75385 (Uniprot-TrEMBL)
ULK2ProteinQ8IYT8 (Uniprot-TrEMBL)
WIPI1ProteinQ5MNZ9 (Uniprot-TrEMBL)
ZFYVE1ProteinQ9HBF4 (Uniprot-TrEMBL)


ComplexCPX-373 (Complex Portal)

Annotated Interactions

No annotated interactions

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