Host-pathogen interaction of human coronaviruses - autophagy (Homo sapiens)

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1EDEMosomeAutophagosomeDMV double membrane vesicleLysozomeLegendphosphorylationSARS, IBV, MHVMaturationvirus protein(inactive)InitiationMTORATG13ULK1PIK3C3BECN1ULK2ZFYVE1WIPI1autophagyinitiationcomplexPIK3R4nsp6RB1CC1ULK1PULK2PPPMTORERNucleationElongationnsp567PRRSVMHV, EAVinfectionSARS, IBV, MHVnsp6nsp567PRRSVAutolysosomevirus type/speciesPhosphorylationPRRSVPATG13PATG7ATG10ATG5ATG12ATG12ATG5ATG16L1ATG3ATG4AATG7ATG16L2ATG16L1ATG16L2ATG5ATG12PELC3LC3PE


Induction and modulation of autophagy system during human corona virus infection.

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Ontology Terms



  1. Fung TS, Liu DX; ''Human Coronavirus: Host-Pathogen Interaction.''; Annu Rev Microbiol, 2019 PubMed Europe PMC Scholia
  2. Cottam EM, Whelband MC, Wileman T; ''Coronavirus NSP6 restricts autophagosome expansion.''; Autophagy, 2014 PubMed Europe PMC Scholia


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116597view19:12, 8 May 2021EweitzModified title
112163view18:30, 29 September 2020Khanspersfixed ptm state comments
110820view07:40, 10 June 2020FehrhartModified description
110819view07:38, 10 June 2020Fehrhartadded reference
110814view22:43, 9 June 2020Mkutmonfixed unconnected line
110727view19:00, 29 May 2020Khansperschanged xrefs to uniprot
110726view18:47, 29 May 2020Khanspersupdated legend, updated ATG part, changed free labels into labels on objects
110725view17:58, 29 May 2020Khanspersadded phosphosites for ULK1, updated representation of ULK/ATG13 dephosphorylation, updated legend
110204view10:47, 24 April 2020Fehrhartupdated legend
110199view20:38, 23 April 2020EgonwTyped proteins as Type="Protein"
109983view21:26, 8 April 2020EgonwAdded possibly the first complex identifier.
109982view21:13, 8 April 2020EgonwAdded a Complex data node (with title from Complex Portal)
109972view18:17, 8 April 2020AlexanderPicoupdated sars nodes per #covidpathways guidelines
109848view11:34, 2 April 2020Fehrhartchanged virus protein visualization
109820view15:01, 1 April 2020FehrhartFixed a comment error
109633view18:28, 27 March 2020AlexanderPicoOntology Term : 'autophagy pathway' added !
109629view18:26, 27 March 2020AlexanderPicoOntology Term : 'severe acute respiratory syndrome' added !
109628view18:21, 27 March 2020AlexanderPicoAdded P and L modifications as states
109627view18:09, 27 March 2020FehrhartOntology Term : 'viral infectious disease' added !
109626view18:09, 27 March 2020FehrhartOntology Term : 'disease pathway' added !
109625view18:09, 27 March 2020FehrhartModified title
109624view18:06, 27 March 2020FehrhartNew pathway

External references


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NameTypeDatabase referenceComment
ATG10ProteinQ9H0Y0 (Uniprot-TrEMBL)
ATG12ProteinO94817 (Uniprot-TrEMBL)
ATG13GeneProductENSG00000175224 (Ensembl)
ATG16L1ProteinQ676U5 (Uniprot-TrEMBL)
ATG16L2ProteinQ8NAA4 (Uniprot-TrEMBL)
ATG3ProteinQ9NT62 (Uniprot-TrEMBL)
ATG4AProteinQ8WYN0 (Uniprot-TrEMBL)
ATG5ProteinQ9H1Y0 (Uniprot-TrEMBL)
ATG7ProteinO95352 (Uniprot-TrEMBL)
BECN1GeneProductENSG00000126581 (Ensembl) beclin 1
LC3GeneProductQ9H492 (Uniprot-TrEMBL)
MTORGeneProductENSG00000198793 (Ensembl)
PEMetabolite16038 (ChEBI)
PIK3C3GeneProductENSG00000078142 (Ensembl) VPS34
PIK3R4GeneProductENSG00000196455 (Ensembl) VPS15
RB1CC1GeneProductENSG00000023287 (Ensembl) FIP200
ULK1GeneProductENSG00000177169 (Ensembl)
ULK2GeneProductENSG00000083290 (Ensembl)
WIPI1GeneProductENSG00000070540 (Ensembl)
ZFYVE1GeneProductENSG00000165861 (Ensembl)


ComplexCPX-373 (Complex Portal)

Annotated Interactions

No annotated interactions

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