Endoplasmic reticulum (ER) stress response in Coronavirus infection (Homo sapiens)

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1, 23GolgiNucleusUnfoldedproteinER-associatedmRNAMVH infectionER protein chaperonesLipid biosynthesisER-associated degradationSplicingMERS 4aAmino acid synthesisAntioxidant responseApoptosisSProsurvival genesdsRNAGlobal proteintranslationER protein chaperonesER lumenHRIERSE-IIUPREPP1JNKnsp15ATF6ERN1ATF4SARS 8abGCN2C/EBPXBP1RIDDCREPKRApoptosisBCL2PEIF2APPGADD34CHOPPERKSARS, IBV infectionSARS, OC43,MHV, IBV infectionERN1PUnfoldedproteinERN1PXBP1uHSPA5ATF6UnfoldedproteinATF6ATF6-p50SARS EHSPA5HSPA5HSPA5CytosolHSPA5HSPA5PERKPERKPPEIF2APKRCHOPXBP1dsRNAERSEERSEOC43 infectionSARS, 229E, MHVPKRP


Description

No description

Quality Tags

Ontology Terms

 

Bibliography

  1. Ye J, Rawson RB, Komuro R, Chen X, Davé UP, Prywes R, Brown MS, Goldstein JL; ''ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.''; Mol Cell, 2000 PubMed Europe PMC Scholia
  2. Fung TS, Liu DX; ''Human Coronavirus: Host-Pathogen Interaction.''; Annu Rev Microbiol, 2019 PubMed Europe PMC Scholia
  3. Cui W, Li J, Ron D, Sha B; ''The structure of the PERK kinase domain suggests the mechanism for its activation.''; Acta Crystallogr D Biol Crystallogr, 2011 PubMed Europe PMC Scholia
  4. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ; ''A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.''; Nature, 2020 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
110816view23:31, 9 June 2020KhanspersModified description
110815view22:49, 9 June 2020KhanspersModified title
110810view10:07, 9 June 2020AndraModified title
110793view00:13, 6 June 2020KhanspersModified description
110792view22:17, 5 June 2020Khanspersupdated lit ref for Gordon et al
110767view12:36, 3 June 2020Fehrhartfixed unconnected line fixed stimulation of transcription/translation
110763view21:36, 2 June 2020Khanspersremoved duplicated label
110762view21:35, 2 June 2020Khanspersminor placement change
110761view21:31, 2 June 2020Khanspersadded legend
110760view21:22, 2 June 2020Khanspersnucleus details
110759view21:11, 2 June 2020Khanspersadded PP1 subunits
110677view23:52, 27 May 2020KhanspersModified title
110676view23:51, 27 May 2020KhanspersModified description
110675view23:51, 27 May 2020Khanspersadded S1P, S2P and missing xrefs
110674view23:27, 27 May 2020KhanspersAdded phospho sites
110673view22:22, 27 May 2020Khanspersfixed typo
110672view22:16, 27 May 2020Khanspersadded details and viral proteins
110670view18:45, 27 May 2020KhanspersModified title
110669view18:40, 27 May 2020Khanspersupdated to protein ids, fixed ER
110665view00:29, 27 May 2020KhanspersModified title
110664view00:28, 27 May 2020Khanspersadded third arm, location etc
110630view23:33, 22 May 2020Khanspersspecified interactions
110629view23:19, 22 May 2020Khanspersadded content
110451view22:43, 12 May 2020Khansperscleared up names, added interactions
110198view20:38, 23 April 2020EgonwTyped proteins as Type="Protein"
109971view18:17, 8 April 2020AlexanderPicoupdated sars nodes per #covidpathways guidelines
109855view13:41, 2 April 2020MaintBotThe label just black.
109854view13:40, 2 April 2020MaintBotStyled the virus node.
109726view21:10, 29 March 2020EgonwAdded a Wikidata identifier for nsp15
109643view19:23, 27 March 2020AlexanderPicoOntology Term : 'viral infectious disease' added !
109632view18:27, 27 March 2020AlexanderPicoOntology Term : 'stress response pathway' added !
109631view18:27, 27 March 2020AlexanderPicoOntology Term : 'severe acute respiratory syndrome' added !
109630view18:26, 27 March 2020AlexanderPicoOntology Term : 'disease pathway' added !
109618view17:18, 27 March 2020Khanspersadded lit ref
109615view16:56, 27 March 2020KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ATF4ProteinP18848 (Uniprot-TrEMBL)
ATF6-p50ProteinP18850 (Uniprot-TrEMBL)
ATF6ProteinP18850 (Uniprot-TrEMBL)
ApoptosisPathwayWP354 (WikiPathways)
BCL2ProteinP10415 (Uniprot-TrEMBL)
C/EBPGeneProduct
CHOPProteinP35638 (Uniprot-TrEMBL)
CREGeneProduct
EIF2AProteinQ53XC0 (Uniprot-TrEMBL)
ERN1ProteinO75460 (Uniprot-TrEMBL)
ERSEGeneProduct
ERSE-IIGeneProduct
GADD34ProteinO75807 (Uniprot-TrEMBL)
GCN2ProteinQ9H492 (Uniprot-TrEMBL)
HRIProteinQ9BQI3 (Uniprot-TrEMBL)
HSPA5ProteinP11021 (Uniprot-TrEMBL)
JNKGeneProduct
MERS 4aProtein
PERKProteinQ9NZJ5 (Uniprot-TrEMBL)
PKRProteinP19525 (Uniprot-TrEMBL)
PP1GeneProduct
RIDDPathway
SProtein
SARS 8abGeneProduct
SARS EGeneProduct
UPREGeneProduct
XBP1ProteinP17861 (Uniprot-TrEMBL)
XBP1uProteinP17861 (Uniprot-TrEMBL)
nsp15ProteinQ87917579 (Wikidata)

Annotated Interactions

No annotated interactions

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